Journal ArticleDOI
Noninvasive Imaging of Quantum Dots in Mice
TLDR
Long-term experiments demonstrated that these quantum dots remain fluorescent after at least four months in vivo, using only quantum dots for detection.About:
This article is published in Bioconjugate Chemistry.The article was published on 2004-01-01. It has received 1153 citations till now. The article focuses on the topics: Quantum dot & Fluorescence-lifetime imaging microscopy.read more
Citations
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microPET-Based Biodistribution of Quantum Dots in Living Mice
Meike L. Schipper,Zhen Cheng,Sheen-Woo Lee,Laurent A. Bentolila,Gopal Iyer,Jianghong Rao,Xiaoyuan Chen,Anna M. Wu,Shimon Weiss,Sanjiv S. Gambhir +9 more
TL;DR: Rapid reticuloendothelial system clearance ofQD will require modification of QD for optimal utility in imaging living subjects, and formal quantitative biodistribution/imaging studies will be helpful in studying many types of nanoparticles, including quantum dots.
Journal ArticleDOI
Use of fluorescent probes: their effect on cell biology and limitations.
TL;DR: Practical pitfalls and problems with a variety of fluorescent compounds that are currently used are discussed.
Journal ArticleDOI
Phospholipid Encapsulated Semiconducting Polymer Nanoparticles: Their Use in Cell Imaging and Protein Attachment
TL;DR: SPNs were used in simple fluorescence imaging experiments and showed uptake in SH-SY5Y neuroblastoma and live HeLa cells, and appear to be a promising imaging agent in biomedical and imaging applications.
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Nanodiagnostics: A New Frontier for Clinical Laboratory Medicine
TL;DR: Nanodiagnostic assays promise increased sensitivity, multiplexing capabilities, and reduced cost for many diagnostic applications as well as intracellular imaging.
Journal ArticleDOI
The state of nanoparticle-based nanoscience and biotechnology: Progress, promises, and challenges
Beatriz Pelaz,Beatriz Pelaz,Sarah Jaber,Dorleta Jimenez de Aberasturi,Dorleta Jimenez de Aberasturi,Verena Wulf,Takuzo Aida,Jesús M. de la Fuente,Jochen Feldmann,Hermann E. Gaub,Lee Josephson,Cherie R. Kagan,Nicholas A. Kotov,Luis M. Liz-Marzán,Hedi Mattoussi,Paul Mulvaney,Christopher B. Murray,Andrey L. Rogach,Paul S. Weiss,Itamar Willner,Wolfgang J. Parak +20 more
TL;DR: The state-of-the-art, current hot topics, and future directions based on the following aspects are discussed: narrow size-distribution NPs can exhibit protein-like properties.
References
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Journal ArticleDOI
Semiconductor Nanocrystals as Fluorescent Biological Labels
TL;DR: Semiconductor nanocrystals prepared for use as fluorescent probes in biological staining and diagnostics have a narrow, tunable, symmetric emission spectrum and are photochemically stable.
Journal ArticleDOI
Quantum Dot Bioconjugates for Ultrasensitive Nonisotopic Detection
Warren C. W. Chan,Shuming Nie +1 more
TL;DR: Highly luminescent semiconductor quantum dots (zinc sulfide-capped cadmium selenide) have been covalently coupled to biomolecules for use in ultrasensitive biological detection and these nanometer-sized conjugates are water-soluble and biocompatible.
Journal Article
Long-Circulating and Target-Specific Nanoparticles: Theory to Practice
TL;DR: The surface mechanisms, which affords red blood cells long-circulatory lives and the ability of specific microorganisms to evade macrophage recognition, are explored and the rational approaches in the design as well as the biological performance of such constructs are assessed.
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Nanoparticles in cancer therapy and diagnosis
TL;DR: The in vivo fate of these systems, after intravascular or tumoral administration, is discussed, as well as the mechanism involved in tumor regression, and the application of nanoparticles in imaging for cancer diagnosis is focused on.
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Effect of pegylation on pharmaceuticals
J. Milton Harris,Robert B. Chess +1 more
TL;DR: How PEGylation can result in drugs that are often more effective and safer, and which show improved patient convenience and compliance are reviewed.