Journal ArticleDOI
Noninvasive Imaging of Quantum Dots in Mice
TLDR
Long-term experiments demonstrated that these quantum dots remain fluorescent after at least four months in vivo, using only quantum dots for detection.About:
This article is published in Bioconjugate Chemistry.The article was published on 2004-01-01. It has received 1153 citations till now. The article focuses on the topics: Quantum dot & Fluorescence-lifetime imaging microscopy.read more
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Nanomaterial translocation--the biokinetics, tissue accumulation, toxicity and fate of materials in secondary organs--a review
TL;DR: The overall aim of this review is to outline the data currently available in the literature on the biokinetics, accumulation, toxicity and eventual fate of NMs in order to assess the potential risks posed by NMs to secondary organs.
Journal ArticleDOI
Pharmacokinetics of nanomaterials: an overview of carbon nanotubes, fullerenes and quantum dots
TL;DR: This review focuses on the disposition of carbon based fullerenes and nanotubes, as well as quantum dots (QD) after parenteral administration to primarily rodents.
Journal ArticleDOI
In vitro and in vivo imaging with quantum dots
Chao Wang,Xue Gao,Xingguang Su +2 more
TL;DR: The unique tunable optical and chemical properties of QDs have been exploited in a growing array of biomedical applications including clinical diagnostics and molecular, cellular, and tumor imaging.
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Pegylated, steptavidin-conjugated quantum dots are effective detection elements for reverse-phase protein microarrays.
David Geho,Nicholas Lahar,Prem P. Gurnani,Michael L. Huebschman,Paul C. Herrmann,Virginia Espina,Alice Shi,Julia Wulfkuhle,Harold R. Garner,Emanuel F. Petricoin,Lance A. Liotta,Kevin P. Rosenblatt +11 more
TL;DR: Hyperspectral imaging of the quantum dot microarray enabled unamplified detection of signaling proteins within defined cellular lysates, which indicates that this approach may be amenable to multiplexed, high-throughput reverse-phase protein microarrays in which numerous analytes are measured in parallel within a single spot.
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Core-shell silica nanoparticles as fluorescent labels for nanomedicine.
Jinhyang Choi,Andrew Burns,Rebecca M. Williams,Zongziang Zhou,Andrea Flesken-Nikitin,Warren R. Zipfel,Ulrich Wiesner,Alexander Yu. Nikitin +7 more
TL;DR: It is demonstrated that fluorescent core-shell silica nanoparticles with narrow size distributions and enhanced photostability represent a powerful novel imaging tool within the emerging field of nanomedicine.
References
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Journal ArticleDOI
Semiconductor Nanocrystals as Fluorescent Biological Labels
TL;DR: Semiconductor nanocrystals prepared for use as fluorescent probes in biological staining and diagnostics have a narrow, tunable, symmetric emission spectrum and are photochemically stable.
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Quantum Dot Bioconjugates for Ultrasensitive Nonisotopic Detection
Warren C. W. Chan,Shuming Nie +1 more
TL;DR: Highly luminescent semiconductor quantum dots (zinc sulfide-capped cadmium selenide) have been covalently coupled to biomolecules for use in ultrasensitive biological detection and these nanometer-sized conjugates are water-soluble and biocompatible.
Journal Article
Long-Circulating and Target-Specific Nanoparticles: Theory to Practice
TL;DR: The surface mechanisms, which affords red blood cells long-circulatory lives and the ability of specific microorganisms to evade macrophage recognition, are explored and the rational approaches in the design as well as the biological performance of such constructs are assessed.
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Nanoparticles in cancer therapy and diagnosis
TL;DR: The in vivo fate of these systems, after intravascular or tumoral administration, is discussed, as well as the mechanism involved in tumor regression, and the application of nanoparticles in imaging for cancer diagnosis is focused on.
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Effect of pegylation on pharmaceuticals
J. Milton Harris,Robert B. Chess +1 more
TL;DR: How PEGylation can result in drugs that are often more effective and safer, and which show improved patient convenience and compliance are reviewed.