Journal ArticleDOI
Noninvasive Imaging of Quantum Dots in Mice
TLDR
Long-term experiments demonstrated that these quantum dots remain fluorescent after at least four months in vivo, using only quantum dots for detection.About:
This article is published in Bioconjugate Chemistry.The article was published on 2004-01-01. It has received 1153 citations till now. The article focuses on the topics: Quantum dot & Fluorescence-lifetime imaging microscopy.read more
Citations
More filters
Journal ArticleDOI
The impact of PEGylation patterns on the in vivo biodistribution of mixed shell micelles
Hongjun Gao,Jinjian Liu,Cuihong Yang,Tangjian Cheng,Liping Chu,Hongyan Xu,Aimin Meng,Saijun Fan,Linqi Shi,Jianfeng Liu +9 more
TL;DR: The present study demonstrated that the PEGylated micelles with short hydrophilic PEG chains mixed on the surface were cleared quickly by the reticuloendothelial system (RES), and the single PEG2k P EGylated mouselles could efficiently prolong the blood circulation time and increase their deposition in tumor sites.
Journal ArticleDOI
Synthesis and Use of Tris(trimethylsilyl)antimony for the Preparation of InSb Quantum Dots
TL;DR: In this paper, a straightforward experimental procedure was developed for the synthesis of highly crystalline InSb quantum dots (QDs), obtained via transsilyation of In(O2CCH3)3 with tris(trimethylsilyl)-antimony in the presence of coordinating ligands.
Journal ArticleDOI
Functionalization of quantum dots with multidentate zwitterionic ligands: impact on cellular interactions and cytotoxicity
TL;DR: Engineering the surface charge density and functionalization of nanoparticles, by multidentate zwitterionic polymeric ligands, provides a strategy to tune the surface properties of QDs, which impacts their cytotoxicity and cellular interaction at the nano-bio interface.
Journal ArticleDOI
High-Resolution Whole-Mount In Situ Hybridization Using Quantum Dot Nanocrystals
TL;DR: A method for direct QD labeling of modified oligonucleotide probes through streptavidin-biotin and antibody-mediated interactions (anti-FITC and anti-digoxigenin) that alleviates issues of photostability and limited brightness plaguing organic fluorophores and allows fluorescent imaging of cleared embryos.
Journal ArticleDOI
Photoluminescence of CdSe and CdSe/ZnS quantum dots: Modifications for making the invisible visible at ensemble and single-molecule levels
Edakkattuparambil Sidharth Shibu,Morihiko Hamada,Morihiko Hamada,Shunsuke Nakanishi,Shin-ichi Wakida,Vasudevanpillai Biju,Vasudevanpillai Biju +6 more
TL;DR: In this paper, the authors provide an overview of recent research on the modulation of quantum dots photoluminescence and the applications of quantum dot to bioimaging, in particular, they summarize the physiochemical factors that affect the photolumininescence of CdSe or cdSe/ZnS quantum dots at ensemble and single-molecule levels.
References
More filters
Journal ArticleDOI
Semiconductor Nanocrystals as Fluorescent Biological Labels
TL;DR: Semiconductor nanocrystals prepared for use as fluorescent probes in biological staining and diagnostics have a narrow, tunable, symmetric emission spectrum and are photochemically stable.
Journal ArticleDOI
Quantum Dot Bioconjugates for Ultrasensitive Nonisotopic Detection
Warren C. W. Chan,Shuming Nie +1 more
TL;DR: Highly luminescent semiconductor quantum dots (zinc sulfide-capped cadmium selenide) have been covalently coupled to biomolecules for use in ultrasensitive biological detection and these nanometer-sized conjugates are water-soluble and biocompatible.
Journal Article
Long-Circulating and Target-Specific Nanoparticles: Theory to Practice
TL;DR: The surface mechanisms, which affords red blood cells long-circulatory lives and the ability of specific microorganisms to evade macrophage recognition, are explored and the rational approaches in the design as well as the biological performance of such constructs are assessed.
Journal ArticleDOI
Nanoparticles in cancer therapy and diagnosis
TL;DR: The in vivo fate of these systems, after intravascular or tumoral administration, is discussed, as well as the mechanism involved in tumor regression, and the application of nanoparticles in imaging for cancer diagnosis is focused on.
Journal ArticleDOI
Effect of pegylation on pharmaceuticals
J. Milton Harris,Robert B. Chess +1 more
TL;DR: How PEGylation can result in drugs that are often more effective and safer, and which show improved patient convenience and compliance are reviewed.