Journal ArticleDOI
Noninvasive Imaging of Quantum Dots in Mice
TLDR
Long-term experiments demonstrated that these quantum dots remain fluorescent after at least four months in vivo, using only quantum dots for detection.About:
This article is published in Bioconjugate Chemistry.The article was published on 2004-01-01. It has received 1153 citations till now. The article focuses on the topics: Quantum dot & Fluorescence-lifetime imaging microscopy.read more
Citations
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Journal ArticleDOI
Challenges in quantum dot-neuron active interfacing.
Natalia Gomez,Jessica O. Winter,Felice Shieh,Aaron E. Saunders,Brian A. Korgel,Christine E. Schmidt +5 more
TL;DR: The initial investigations using mercaptoacetic acid-coated CdS and CdTe qdots as a simple model to interface with neuron cell surface receptors under physiological conditions uncovered two significant technological hurdles: nonspecific binding and endocytosis.
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The use of quantum dots for analysis of chick CAM vasculature.
TL;DR: It is demonstrated that QDs are fixable with low fluorescence loss and thus can be used in conjunction with histological processing for further sample analysis and virtually eliminated all chick-derived autofluorescence and improved depth-of-field imaging.
Journal ArticleDOI
Quantum dots synthesis and biological applications as imaging and drug delivery systems
TL;DR: This review of the recent trends in QD synthesis, surface modification, and biological applications particularly for cancer targeting and treatment is summarized.
Journal ArticleDOI
Cys-diabody quantum dot conjugates (immunoQdots) for cancer marker detection.
Bhaswati Barat,Shannon J. Sirk,Katelyn E. McCabe,Jianqing Li,Eric J. Lepin,Roland Remenyi,Ai Leen Koh,Tove Olafsen,Sanjiv S. Gambhir,Shimon Weiss,Anna M. Wu +10 more
TL;DR: The present thiol-specific conjugation method demonstrates a general approach for site-specific oriented coupling of cys-diabodies to a wide variety of nanoparticles without disturbing the antigen binding site and maintaining small size compared to intact antibody.
Journal ArticleDOI
Highly Fluorescent and Stable Quantum Dot-Polymer-Layered Double Hydroxide Composites
TL;DR: In this article, a designed strategy for a synthesis of highly luminescent and photostable composites by incorporating quantum dots (QDs) into layered double hydroxide (LDH) matrices without deterioration of a photoluminescence (PL) efficiency of the fluorophores during the entire processes of composite formations was presented.
References
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Journal ArticleDOI
Semiconductor Nanocrystals as Fluorescent Biological Labels
TL;DR: Semiconductor nanocrystals prepared for use as fluorescent probes in biological staining and diagnostics have a narrow, tunable, symmetric emission spectrum and are photochemically stable.
Journal ArticleDOI
Quantum Dot Bioconjugates for Ultrasensitive Nonisotopic Detection
Warren C. W. Chan,Shuming Nie +1 more
TL;DR: Highly luminescent semiconductor quantum dots (zinc sulfide-capped cadmium selenide) have been covalently coupled to biomolecules for use in ultrasensitive biological detection and these nanometer-sized conjugates are water-soluble and biocompatible.
Journal Article
Long-Circulating and Target-Specific Nanoparticles: Theory to Practice
TL;DR: The surface mechanisms, which affords red blood cells long-circulatory lives and the ability of specific microorganisms to evade macrophage recognition, are explored and the rational approaches in the design as well as the biological performance of such constructs are assessed.
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Nanoparticles in cancer therapy and diagnosis
TL;DR: The in vivo fate of these systems, after intravascular or tumoral administration, is discussed, as well as the mechanism involved in tumor regression, and the application of nanoparticles in imaging for cancer diagnosis is focused on.
Journal ArticleDOI
Effect of pegylation on pharmaceuticals
J. Milton Harris,Robert B. Chess +1 more
TL;DR: How PEGylation can result in drugs that are often more effective and safer, and which show improved patient convenience and compliance are reviewed.