Journal ArticleDOI
Noninvasive Imaging of Quantum Dots in Mice
TLDR
Long-term experiments demonstrated that these quantum dots remain fluorescent after at least four months in vivo, using only quantum dots for detection.About:
This article is published in Bioconjugate Chemistry.The article was published on 2004-01-01. It has received 1153 citations till now. The article focuses on the topics: Quantum dot & Fluorescence-lifetime imaging microscopy.read more
Citations
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Forming water-soluble CdSe/ZnS QDs using amphiphilic polymers, stearyl methacrylate/methylacrylate copolymers with different hydrophobic moiety ratios and their optical properties and stability
Zhanyu Wu,Yili Zhao,Fangping Qiu,Yapeng Li,Shuwei Wang,Bohan Yang,Liang Chen,Jinghui Sun,Jingyuan Wang +8 more
TL;DR: In this article, an amphiphilic stearyl methacrylate/methylacrylic acid copolymers (PSMs) were used as phase transfer reagents to convert CdSe/ZnS core-shell quantum dots (QDs) in chloroform to water-soluble PSMs-coated quantum dots.
Journal ArticleDOI
Human epithelial cell processing of carbon and gold nanoparticles
Barbara J. Panessa-Warren,John B. Warren,Mathew M. Maye,Daniel van der Lelie,Oleg Gang,Stanislaus S. Wong,Berhane Ghebrehiwet,G.T. Tortora,James A. Misewich +8 more
TL;DR: Vital staining used to identify cellular necrosis following nanoparticle exposure, was sometimes misleading showing cell necrosis statistics similar to normal controls, when TEM analysis revealed intracellular and organellar damage in identically treated cells.
Journal ArticleDOI
Quantum Dots: An Emerging Tool for Point-of-Care Testing
TL;DR: The QDs have a narrow emission peak, size-dependent emission wavelength, and broad excitation range which can be utilized for diverse biomedical applications such as molecular imaging, biosensing, and diagnostic systems.
Journal ArticleDOI
Biodistribution and Systemic Effects in Mice Following Intravenous Administration of Cadmium Telluride Quantum Dot Nanoparticles.
Kathy C Nguyen,Kathy C Nguyen,Yan Zhang,Julie Todd,Kevin Kittle,Dominique Patry,Don Caldwell,Michelle Lalande,Scott Smith,Douglas Parks,Martha Navarro,Andrey Massarsky,Thomas W. Moon,William G. Willmore,Azam F. Tayabali,Azam F. Tayabali +15 more
TL;DR: Investigation of the tissue distribution and toxic effects of cadmium telluride quantum dots in male BALB/c mice for up to one week after single-dose intravenous injections demonstrated that the liver is the main target of CdTe-QDs, and that exposure to CdReQDs leads to hepatic and splenic injury, as well as systemic effects, in mice.
Journal ArticleDOI
Quantitative Detection of Engineered Nanoparticles in Tissues and Organs: An Investigation of Efficacy and Linear Dynamic Ranges Using ICP-AES
TL;DR: In this paper, the Inductively Coupled Plasma-Atomic Emission Spectroscopy (ICP-AES) was used for quantifying nanoparticles in excised organs, after in vivo dosing.
References
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Journal ArticleDOI
Semiconductor Nanocrystals as Fluorescent Biological Labels
TL;DR: Semiconductor nanocrystals prepared for use as fluorescent probes in biological staining and diagnostics have a narrow, tunable, symmetric emission spectrum and are photochemically stable.
Journal ArticleDOI
Quantum Dot Bioconjugates for Ultrasensitive Nonisotopic Detection
Warren C. W. Chan,Shuming Nie +1 more
TL;DR: Highly luminescent semiconductor quantum dots (zinc sulfide-capped cadmium selenide) have been covalently coupled to biomolecules for use in ultrasensitive biological detection and these nanometer-sized conjugates are water-soluble and biocompatible.
Journal Article
Long-Circulating and Target-Specific Nanoparticles: Theory to Practice
TL;DR: The surface mechanisms, which affords red blood cells long-circulatory lives and the ability of specific microorganisms to evade macrophage recognition, are explored and the rational approaches in the design as well as the biological performance of such constructs are assessed.
Journal ArticleDOI
Nanoparticles in cancer therapy and diagnosis
TL;DR: The in vivo fate of these systems, after intravascular or tumoral administration, is discussed, as well as the mechanism involved in tumor regression, and the application of nanoparticles in imaging for cancer diagnosis is focused on.
Journal ArticleDOI
Effect of pegylation on pharmaceuticals
J. Milton Harris,Robert B. Chess +1 more
TL;DR: How PEGylation can result in drugs that are often more effective and safer, and which show improved patient convenience and compliance are reviewed.