Journal ArticleDOI
Noninvasive Imaging of Quantum Dots in Mice
TLDR
Long-term experiments demonstrated that these quantum dots remain fluorescent after at least four months in vivo, using only quantum dots for detection.About:
This article is published in Bioconjugate Chemistry.The article was published on 2004-01-01. It has received 1153 citations till now. The article focuses on the topics: Quantum dot & Fluorescence-lifetime imaging microscopy.read more
Citations
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Tracking bio-molecules in live cells using quantum dots
TL;DR: Recent advancements in using quantum dots as SPT probes for live cell experiments are reviewed.
Journal ArticleDOI
PET Imaging and Biodistribution of Silicon Quantum Dots in Mice.
TL;DR: A new macrocyclic ligand-(64)Cu(2+) complex was synthesized and used to label dextran-coated silicon quantum dots (QD), which showed exceptional stability and demonstrated by no loss radiolabel under a ligand competition reaction with EDTA.
Journal ArticleDOI
Two-photon polymerization of microneedles for transdermal drug delivery
TL;DR: It is anticipated that the use of two-photon polymerization as well as two- phyton polymerization-micromolding for fabrication of microneedles and other microstructured drug delivery devices will increase over the coming years.
Journal ArticleDOI
In vivo selection of phage for the optical imaging of PC-3 human prostate carcinoma in mice.
Jessica R. Newton,Kimberly A. Kelly,Umar Mahmood,Ralph Weissleder,Susan L. Deutscher,Susan L. Deutscher +5 more
TL;DR: Results show proof of principle that disease-specific library-derived fluorescent probes can be rapidly developed for use in the early detection of cancers by optical means.
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A review on fluorescent inorganic nanoparticles for optical sensing applications
TL;DR: A rational review of the development of fluorescent inorganic nanoparticles in the area of optical sensing can be found in this paper, where the application aspects for use as optical sensing receptors are highlighted with the focus on the possible sensing mechanisms, the crucial optimisation processes during the development, and the options available for data analysis on the signals recorded from the optical sensors.
References
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Journal ArticleDOI
Semiconductor Nanocrystals as Fluorescent Biological Labels
TL;DR: Semiconductor nanocrystals prepared for use as fluorescent probes in biological staining and diagnostics have a narrow, tunable, symmetric emission spectrum and are photochemically stable.
Journal ArticleDOI
Quantum Dot Bioconjugates for Ultrasensitive Nonisotopic Detection
Warren C. W. Chan,Shuming Nie +1 more
TL;DR: Highly luminescent semiconductor quantum dots (zinc sulfide-capped cadmium selenide) have been covalently coupled to biomolecules for use in ultrasensitive biological detection and these nanometer-sized conjugates are water-soluble and biocompatible.
Journal Article
Long-Circulating and Target-Specific Nanoparticles: Theory to Practice
TL;DR: The surface mechanisms, which affords red blood cells long-circulatory lives and the ability of specific microorganisms to evade macrophage recognition, are explored and the rational approaches in the design as well as the biological performance of such constructs are assessed.
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Nanoparticles in cancer therapy and diagnosis
TL;DR: The in vivo fate of these systems, after intravascular or tumoral administration, is discussed, as well as the mechanism involved in tumor regression, and the application of nanoparticles in imaging for cancer diagnosis is focused on.
Journal ArticleDOI
Effect of pegylation on pharmaceuticals
J. Milton Harris,Robert B. Chess +1 more
TL;DR: How PEGylation can result in drugs that are often more effective and safer, and which show improved patient convenience and compliance are reviewed.