Journal ArticleDOI
Noninvasive Imaging of Quantum Dots in Mice
TLDR
Long-term experiments demonstrated that these quantum dots remain fluorescent after at least four months in vivo, using only quantum dots for detection.About:
This article is published in Bioconjugate Chemistry.The article was published on 2004-01-01. It has received 1153 citations till now. The article focuses on the topics: Quantum dot & Fluorescence-lifetime imaging microscopy.read more
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Journal ArticleDOI
Quantum dot mediated imaging of atherosclerosis
Ashwath Jayagopal,Yan Ru Su,John L. Blakemore,MacRae F. Linton,Sergio Fazio,Frederick R. Haselton +5 more
TL;DR: The method for tracking leukocytes in lesions enables high signal-to-noise ratio imaging of multiple cell types and biomarkers simultaneously within the same specimen, and has great utility in studies aimed at investigating the role of distinct circulating leukocyte subsets in plaque development and progression.
Journal ArticleDOI
Non-mammalian vertebrate embryos as models in nanomedicine.
Martina Giannaccini,Martina Giannaccini,Alfred Cuschieri,Luciana Dente,Vittoria Raffa,Vittoria Raffa +5 more
TL;DR: The feasibility and potential applications of non-mammalian vertebral animals, such as zebrafish, xenopus, and chicken as animal models in nanomedicine research are discussed.
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In vivo evaluation of vascular-targeted spheroidal microparticles for imaging and drug delivery application in atherosclerosis.
Katawut Namdee,Alex J. Thompson,Alexander W. Golinski,Supriya Mocherla,Diane Bouis,Omolola Eniola-Adefeso +5 more
TL;DR: Particle shape and size should be considered in the design of carrier systems to target atherosclerosis, as these parameters can be tuned to improve carrier performance.
Journal ArticleDOI
A dual-colored bio-marker made of doped?ZnO nanocrystals
TL;DR: The results showed the potential of the pure ZNO and Co-doped ZnO nanocrystals for live imaging of both human cells and plant systems and Cytotoxicity tests showed that the aminosilanes capped nanoparticles are non-toxic.
Journal ArticleDOI
Ultrasharp light-scattering resonances of structured nanospheres: effects of size-dependent dielectric functions.
TL;DR: Here it is shown that such ultrasharp labels cannot be fabricated in reality because the effects of size-dependent dielectric functions result in the five- to tenfold broadening of resonant scattering peaks.
References
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Journal ArticleDOI
Semiconductor Nanocrystals as Fluorescent Biological Labels
TL;DR: Semiconductor nanocrystals prepared for use as fluorescent probes in biological staining and diagnostics have a narrow, tunable, symmetric emission spectrum and are photochemically stable.
Journal ArticleDOI
Quantum Dot Bioconjugates for Ultrasensitive Nonisotopic Detection
Warren C. W. Chan,Shuming Nie +1 more
TL;DR: Highly luminescent semiconductor quantum dots (zinc sulfide-capped cadmium selenide) have been covalently coupled to biomolecules for use in ultrasensitive biological detection and these nanometer-sized conjugates are water-soluble and biocompatible.
Journal Article
Long-Circulating and Target-Specific Nanoparticles: Theory to Practice
TL;DR: The surface mechanisms, which affords red blood cells long-circulatory lives and the ability of specific microorganisms to evade macrophage recognition, are explored and the rational approaches in the design as well as the biological performance of such constructs are assessed.
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Nanoparticles in cancer therapy and diagnosis
TL;DR: The in vivo fate of these systems, after intravascular or tumoral administration, is discussed, as well as the mechanism involved in tumor regression, and the application of nanoparticles in imaging for cancer diagnosis is focused on.
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Effect of pegylation on pharmaceuticals
J. Milton Harris,Robert B. Chess +1 more
TL;DR: How PEGylation can result in drugs that are often more effective and safer, and which show improved patient convenience and compliance are reviewed.