Journal ArticleDOI
Noninvasive Imaging of Quantum Dots in Mice
TLDR
Long-term experiments demonstrated that these quantum dots remain fluorescent after at least four months in vivo, using only quantum dots for detection.About:
This article is published in Bioconjugate Chemistry.The article was published on 2004-01-01. It has received 1153 citations till now. The article focuses on the topics: Quantum dot & Fluorescence-lifetime imaging microscopy.read more
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Fluorescence diffuse optical tomography using upconverting nanoparticles
TL;DR: A method for autofluorescence-insensitive FDOT using nonlinear upconverting nanoparticles (NaYF4:Yb3+/Tm3+) in a tissue phantom under excitation intensities well below tissue-damage thresholds is reported.
Journal ArticleDOI
Semiconductor Quantum Dots for Biosensing and In Vivo Imaging
TL;DR: This review will briefly survey the optical properties of QDs, the biofunctionalization strategies, and focus on their biosensing and in vivo imaging applications, and conclude with a discussion on the issues and perspectives on QDs as biosensing probes and in vitro imaging agents.
Emerging trends in nanobiotechnology.
TL;DR: This review focuses on the emerging trends in the development of wide array of nanomaterials for biological applications and mainly the QDs - their properties, toxicity studies and some of their biological applications like labeling of cellular structures/molecules, cell uptake, biocompatibility, bioconjugation etc.
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Optimal design of structured nanospheres for ultrasharp light-scattering resonances as molecular imaging multilabels.
TL;DR: This work describes a different concept of multilabel molecular imaging that utilizes resonant light-scattering spectroscopy ofMultilayered nanospheres to achieve tunable ultrasharp resonance peaks with widths as narrow as 10 nm and demonstrates that dozens of molecular targets can potentially be imaged simultaneously using this approach.
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A novel β-Cyclodextrin-QDs optical biosensor for the determination of amantadine and its application in cell imaging
TL;DR: A novel optical biosensor for amantadine (AD) determination has been constructed successfully based on the fluorescence resonance energy transfer (FRET) between water-soluble β-Cyclodextrin-functionalized CdTe quantum dots (QDs) and Rhodamine B (RB).
References
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Journal ArticleDOI
Semiconductor Nanocrystals as Fluorescent Biological Labels
TL;DR: Semiconductor nanocrystals prepared for use as fluorescent probes in biological staining and diagnostics have a narrow, tunable, symmetric emission spectrum and are photochemically stable.
Journal ArticleDOI
Quantum Dot Bioconjugates for Ultrasensitive Nonisotopic Detection
Warren C. W. Chan,Shuming Nie +1 more
TL;DR: Highly luminescent semiconductor quantum dots (zinc sulfide-capped cadmium selenide) have been covalently coupled to biomolecules for use in ultrasensitive biological detection and these nanometer-sized conjugates are water-soluble and biocompatible.
Journal Article
Long-Circulating and Target-Specific Nanoparticles: Theory to Practice
TL;DR: The surface mechanisms, which affords red blood cells long-circulatory lives and the ability of specific microorganisms to evade macrophage recognition, are explored and the rational approaches in the design as well as the biological performance of such constructs are assessed.
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Nanoparticles in cancer therapy and diagnosis
TL;DR: The in vivo fate of these systems, after intravascular or tumoral administration, is discussed, as well as the mechanism involved in tumor regression, and the application of nanoparticles in imaging for cancer diagnosis is focused on.
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Effect of pegylation on pharmaceuticals
J. Milton Harris,Robert B. Chess +1 more
TL;DR: How PEGylation can result in drugs that are often more effective and safer, and which show improved patient convenience and compliance are reviewed.