Journal ArticleDOI
Noninvasive Imaging of Quantum Dots in Mice
TLDR
Long-term experiments demonstrated that these quantum dots remain fluorescent after at least four months in vivo, using only quantum dots for detection.About:
This article is published in Bioconjugate Chemistry.The article was published on 2004-01-01. It has received 1153 citations till now. The article focuses on the topics: Quantum dot & Fluorescence-lifetime imaging microscopy.read more
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In vivo optical imaging using quantum dots for the management of brain tumors
TL;DR: Macrophage-mediated delivery of quantum dots to brain tumors may represent a novel technique to label tumors preoperatively, providing the surgeon with real-time optical feedback during the resection and biopsy of brain tumors.
Patent
Tissue engineered blood vessels
TL;DR: In this article, a method for preparing artificial blood vessels by preconditioning a matrix seeded with endothelial cells to fluid flow conditions that mimic blood flow was proposed, and the method was applied to the preparation of artificial blood vessel.
Journal ArticleDOI
Tailor made magnetic nanolights: fabrication to cancer theranostics applications
TL;DR: In this paper, the authors present recent progress of magneto-fluorescent nanoparticles (quantum dots based magnetic nanoparticles, Janus particles, and heterocrystalline fluorescent magnetic materials), comprehensively describing fabrication strategies, types, and biomedical applications.
Journal ArticleDOI
Effects of nanoencapsulation and PEGylation on biodistribution of indocyanine green in healthy mice: quantitative fluorescence imaging and analysis of organs.
Baharak Bahmani,Christian Y Lytle,Ameae M Walker,Sharad Gupta,Valentine I. Vullev,Bahman Anvari +5 more
TL;DR: The results suggest that encapsulation of ICG in these PEGylated constructs is an effective approach to prolong the circulation time ofICG and delay its hepatic accumulation and indicate that PAH and ICG-doped nanocapsules (ICG-NCs) are not cytotoxic at the levels used in this study.
Journal ArticleDOI
Clickable-Zwitterionic Copolymer Capped-Quantum Dots for in Vivo Fluorescence Tumor Imaging
Laura Trapiella-Alfonso,Thomas Pons,Nicolas Lequeux,Ludovic Leleu,Juliette Grimaldi,Mariana Tasso,Edward Oujagir,Edward Oujagir,Edward Oujagir,Johanne Seguin,Johanne Seguin,Johanne Seguin,Fanny d’Orlyé,Christian Girard,Bich-Thuy Doan,Anne Varenne +15 more
TL;DR: The complete design and characterization of a peptide-near-infrared-QD-based nanoprobe for biomedical optical imaging is presented from the synthesis of the QDs and the zwitterionic-azide copolymer ligand, till the final in vivo test through all the characterization steps.
References
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Journal ArticleDOI
Semiconductor Nanocrystals as Fluorescent Biological Labels
TL;DR: Semiconductor nanocrystals prepared for use as fluorescent probes in biological staining and diagnostics have a narrow, tunable, symmetric emission spectrum and are photochemically stable.
Journal ArticleDOI
Quantum Dot Bioconjugates for Ultrasensitive Nonisotopic Detection
Warren C. W. Chan,Shuming Nie +1 more
TL;DR: Highly luminescent semiconductor quantum dots (zinc sulfide-capped cadmium selenide) have been covalently coupled to biomolecules for use in ultrasensitive biological detection and these nanometer-sized conjugates are water-soluble and biocompatible.
Journal Article
Long-Circulating and Target-Specific Nanoparticles: Theory to Practice
TL;DR: The surface mechanisms, which affords red blood cells long-circulatory lives and the ability of specific microorganisms to evade macrophage recognition, are explored and the rational approaches in the design as well as the biological performance of such constructs are assessed.
Journal ArticleDOI
Nanoparticles in cancer therapy and diagnosis
TL;DR: The in vivo fate of these systems, after intravascular or tumoral administration, is discussed, as well as the mechanism involved in tumor regression, and the application of nanoparticles in imaging for cancer diagnosis is focused on.
Journal ArticleDOI
Effect of pegylation on pharmaceuticals
J. Milton Harris,Robert B. Chess +1 more
TL;DR: How PEGylation can result in drugs that are often more effective and safer, and which show improved patient convenience and compliance are reviewed.