Journal ArticleDOI
Noninvasive Imaging of Quantum Dots in Mice
TLDR
Long-term experiments demonstrated that these quantum dots remain fluorescent after at least four months in vivo, using only quantum dots for detection.About:
This article is published in Bioconjugate Chemistry.The article was published on 2004-01-01. It has received 1153 citations till now. The article focuses on the topics: Quantum dot & Fluorescence-lifetime imaging microscopy.read more
Citations
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Journal ArticleDOI
Transfer of quantum dots from pregnant mice to pups across the placental barrier.
Maoquan Chu,Qiang Wu,Hui Yang,Ruiqi Yuan,Shengke Hou,Yifeng Yang,Yajuan Zou,Shi Xu,Kaiyi Xu,Ailing Ji,Lingyi Sheng +10 more
TL;DR: It is shown that QDs may be transferred from female mice to their fetuses across the placental barrier and the results suggest that the clinical utility of QDs could be limited in pregnant women.
Journal ArticleDOI
Non-invasive in vivo imaging in small animal research.
TL;DR: The instrumentation available together with corresponding applications reported in the literature with particular emphasis on cancer research are outlined and the issues concerning small animal care during imaging are highlighted.
Journal ArticleDOI
Real time in vivo non-invasive optical imaging using near-infrared fluorescent quantum dots.
Nicole Y. Morgan,Sean J. English,Wei Chen,Victor Chernomordik,Angelo Russo,Paul D. Smith,Amir H. Gandjbakhche +6 more
TL;DR: In this paper, the use of NIR semiconductor nanocrystals in deep-tissue in vivo optical imaging is reported, which is a useful angiographic contrast agent for vessels surrounding and penetrating a murine squamous cell carcinoma in a C3H mouse.
Journal ArticleDOI
Bioimaging of hyaluronic acid derivatives using nanosized carbon dots.
Eun Ji Goh,Ki Su Kim,Yi Rang Kim,Ho Sang Jung,Songeun Beack,Won Ho Kong,Giuliano Scarcelli,Seok Hyun Yun,Seok Hyun Yun,Sei Kwang Hahn,Sei Kwang Hahn +10 more
TL;DR: In vivo real-time bioimaging of Cdots and HA-Cdot conjugates exhibited the target specific delivery of ha derivatives to the liver with abundant HA receptors and the feasibility of HA derivatives as a target-specific drug delivery carrier is confirmed.
Journal ArticleDOI
Optimisation of the synthesis and modification of CdTe quantum dots for enhanced live cell imaging
Stephen J. Byrne,Serena A. Corr,Tatsiana Rakovich,Yurii K. Gun'ko,Yury P. Rakovich,John F. Donegan,Siobhan Mitchell,Yuri Volkov +7 more
TL;DR: It was found that the TGA-stabilised QDs traverse the cell membrane, illuminating the cytoplasm and decorating the nuclear membrane, and highlight the potential use of photoetched CdTe QDs as probes for specific in vitro labelling.
References
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Journal ArticleDOI
Semiconductor Nanocrystals as Fluorescent Biological Labels
TL;DR: Semiconductor nanocrystals prepared for use as fluorescent probes in biological staining and diagnostics have a narrow, tunable, symmetric emission spectrum and are photochemically stable.
Journal ArticleDOI
Quantum Dot Bioconjugates for Ultrasensitive Nonisotopic Detection
Warren C. W. Chan,Shuming Nie +1 more
TL;DR: Highly luminescent semiconductor quantum dots (zinc sulfide-capped cadmium selenide) have been covalently coupled to biomolecules for use in ultrasensitive biological detection and these nanometer-sized conjugates are water-soluble and biocompatible.
Journal Article
Long-Circulating and Target-Specific Nanoparticles: Theory to Practice
TL;DR: The surface mechanisms, which affords red blood cells long-circulatory lives and the ability of specific microorganisms to evade macrophage recognition, are explored and the rational approaches in the design as well as the biological performance of such constructs are assessed.
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Nanoparticles in cancer therapy and diagnosis
TL;DR: The in vivo fate of these systems, after intravascular or tumoral administration, is discussed, as well as the mechanism involved in tumor regression, and the application of nanoparticles in imaging for cancer diagnosis is focused on.
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Effect of pegylation on pharmaceuticals
J. Milton Harris,Robert B. Chess +1 more
TL;DR: How PEGylation can result in drugs that are often more effective and safer, and which show improved patient convenience and compliance are reviewed.