Journal ArticleDOI
Noninvasive Imaging of Quantum Dots in Mice
TLDR
Long-term experiments demonstrated that these quantum dots remain fluorescent after at least four months in vivo, using only quantum dots for detection.About:
This article is published in Bioconjugate Chemistry.The article was published on 2004-01-01. It has received 1153 citations till now. The article focuses on the topics: Quantum dot & Fluorescence-lifetime imaging microscopy.read more
Citations
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Proceedings ArticleDOI
Activatable quantum dots for mouse non-invasive fluorescence imaging
TL;DR: The construction of activatable probes based on quantum dot labels has therefore been undertaken, and long PEG chains are demonstrated to be essential in order to increase the blood circulation time of the particles and avoid their massive storage into the liver.
Proceedings ArticleDOI
Quantum dots as handles for optical manipulation
TL;DR: In this paper, the authors present an Allan variance analysis of individual optically trapped quantum dots and show that the optimal measurement time for experiments involving individual quantum dots is on the order of 0.3 seconds.
Journal ArticleDOI
Functional optical imaging at the microscopic level
Beatriz Y. Salazar Vázquez,Ciel Makena Hightower,F. Sapuppo,Daniel M. Tartakovsky,Marcos Intaglietta +4 more
TL;DR: In this article, the authors used a dual-slit methodology for measuring the extent of the plasma layer, the blood flow velocity, and the direct measurement of oxygen concentration in blood and tissue.
Proceedings ArticleDOI
New ligand design to promote water compatibility of luminescent quantum dots and gold nanoparticles
TL;DR: The design and synthesis of new bidentate ligands to promote biocompatibility of luminescent quantum dots (QDs) and gold nanoparticle (Au-NPs) alike are reported.
References
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Journal ArticleDOI
Semiconductor Nanocrystals as Fluorescent Biological Labels
TL;DR: Semiconductor nanocrystals prepared for use as fluorescent probes in biological staining and diagnostics have a narrow, tunable, symmetric emission spectrum and are photochemically stable.
Journal ArticleDOI
Quantum Dot Bioconjugates for Ultrasensitive Nonisotopic Detection
Warren C. W. Chan,Shuming Nie +1 more
TL;DR: Highly luminescent semiconductor quantum dots (zinc sulfide-capped cadmium selenide) have been covalently coupled to biomolecules for use in ultrasensitive biological detection and these nanometer-sized conjugates are water-soluble and biocompatible.
Journal Article
Long-Circulating and Target-Specific Nanoparticles: Theory to Practice
TL;DR: The surface mechanisms, which affords red blood cells long-circulatory lives and the ability of specific microorganisms to evade macrophage recognition, are explored and the rational approaches in the design as well as the biological performance of such constructs are assessed.
Journal ArticleDOI
Nanoparticles in cancer therapy and diagnosis
TL;DR: The in vivo fate of these systems, after intravascular or tumoral administration, is discussed, as well as the mechanism involved in tumor regression, and the application of nanoparticles in imaging for cancer diagnosis is focused on.
Journal ArticleDOI
Effect of pegylation on pharmaceuticals
J. Milton Harris,Robert B. Chess +1 more
TL;DR: How PEGylation can result in drugs that are often more effective and safer, and which show improved patient convenience and compliance are reviewed.