Journal ArticleDOI
Noninvasive Imaging of Quantum Dots in Mice
TLDR
Long-term experiments demonstrated that these quantum dots remain fluorescent after at least four months in vivo, using only quantum dots for detection.About:
This article is published in Bioconjugate Chemistry.The article was published on 2004-01-01. It has received 1153 citations till now. The article focuses on the topics: Quantum dot & Fluorescence-lifetime imaging microscopy.read more
Citations
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Journal ArticleDOI
A novel near-infrared indocyanine dye-polyethylenimine conjugate allows DNA delivery imaging in vivo.
Andrea Masotti,Paola Vicennati,Federico Boschi,Laura Calderan,Andrea Sbarbati,Giancarlo Ortaggi +5 more
TL;DR: The synthesis of a novel conjugate between a near-infrared indocyanine dye and an organic polyamine polymer (polyethylenimine, PEI) with high chemical stability and good optical properties is reported, making IR820-PEI one of the most effective and versatile indochenine dye polymeric-conjugate reported so far.
Journal ArticleDOI
A primer on the synthesis, water-solubilization, and functionalization of quantum dots, their use as biological sensing agents, and present status.
TL;DR: A historical synopsis of research in this field is presented to help elucidate the origins of the most recent advances in QD-based technology and educate the novice researcher concerning many important aspects of QD synthesis, water-solubilization, functionalization, and usage in biological imaging and sensing.
Journal ArticleDOI
Active cellular sensing with quantum dots: transitioning from research tool to reality; a review.
James B. Delehanty,Kimihiro Susumu,Rachel L. Manthe,Rachel L. Manthe,W. Russ Algar,W. Russ Algar,Igor L. Medintz +6 more
TL;DR: The idea of understanding how to actively incorporate QDs into different types of cellular biosensing is explored, with an emphasis on minimizing potential toxicity, along with discussing the benefits and liabilities of each sensing strategy.
Book ChapterDOI
Visualization of Molecular Activities Inside Living Cells with Fluorescent Labels
Gertrude Bunt,Fred S. Wouters +1 more
TL;DR: An overview of the current status of the young field of molecular-cellular physiology is presented that includes the application of fluorescent labels in the design of biosensors and the major detection schemes used to extract their sensing information.
Journal ArticleDOI
Biochemistry and biomedicine of quantum dots: from biodetection to bioimaging, drug discovery, diagnostics, and therapy.
TL;DR: This review focuses on various applications of QDs, especially in imaging, drug delivery, pharmaceutical analysis, photothermal therapy, biochips, and targeted surgery.
References
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Journal ArticleDOI
Semiconductor Nanocrystals as Fluorescent Biological Labels
TL;DR: Semiconductor nanocrystals prepared for use as fluorescent probes in biological staining and diagnostics have a narrow, tunable, symmetric emission spectrum and are photochemically stable.
Journal ArticleDOI
Quantum Dot Bioconjugates for Ultrasensitive Nonisotopic Detection
Warren C. W. Chan,Shuming Nie +1 more
TL;DR: Highly luminescent semiconductor quantum dots (zinc sulfide-capped cadmium selenide) have been covalently coupled to biomolecules for use in ultrasensitive biological detection and these nanometer-sized conjugates are water-soluble and biocompatible.
Journal Article
Long-Circulating and Target-Specific Nanoparticles: Theory to Practice
TL;DR: The surface mechanisms, which affords red blood cells long-circulatory lives and the ability of specific microorganisms to evade macrophage recognition, are explored and the rational approaches in the design as well as the biological performance of such constructs are assessed.
Journal ArticleDOI
Nanoparticles in cancer therapy and diagnosis
TL;DR: The in vivo fate of these systems, after intravascular or tumoral administration, is discussed, as well as the mechanism involved in tumor regression, and the application of nanoparticles in imaging for cancer diagnosis is focused on.
Journal ArticleDOI
Effect of pegylation on pharmaceuticals
J. Milton Harris,Robert B. Chess +1 more
TL;DR: How PEGylation can result in drugs that are often more effective and safer, and which show improved patient convenience and compliance are reviewed.