Journal ArticleDOI
Noninvasive Imaging of Quantum Dots in Mice
TLDR
Long-term experiments demonstrated that these quantum dots remain fluorescent after at least four months in vivo, using only quantum dots for detection.About:
This article is published in Bioconjugate Chemistry.The article was published on 2004-01-01. It has received 1153 citations till now. The article focuses on the topics: Quantum dot & Fluorescence-lifetime imaging microscopy.read more
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Multifunctional nanoparticles – properties and prospects for their use in human medicine
Nuria Sanvicens,M.-Pilar Marco +1 more
TL;DR: This review addresses the design of multifunctional nanoparticles as an alternative system for drug and gene delivery, which has great potential for therapy in areas, such as cancer and neuropathologies, and discusses the controversy generated by the possible toxic health effects of nanoparticles.
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Quantum dots: bright and versatile in vitro and in vivo fluorescence imaging biosensors
K. David Wegner,Niko Hildebrandt +1 more
TL;DR: Different QD-based imaging applications will be discussed from the technological and the biological point of view, ranging from super-resolution microscopy and single-particle tracking over in vitro cell and tissue imaging to in vivo investigations.
Journal ArticleDOI
Effects of nanomaterial physicochemical properties on in vivo toxicity
TL;DR: The physicochemical properties of four representative nanomaterials (dendrimers, carbon nanotubes, quantum dots, and gold nanoparticles) as it relates to their toxicity after systemic exposure is discussed.
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Nanoprobes with near-infrared persistent luminescence for in vivo imaging.
Quentin le Masne de Chermont,Corinne Chanéac,Johanne Seguin,Fabienne Pellé,Serge Maitrejean,Jean-Pierre Jolivet,Didier Gourier,Michel Bessodes,Daniel Scherman +8 more
TL;DR: Using persistent luminescent nanoparticles suitable for small animal imaging, chemical modification of the nanoparticles' surface led to lung or liver targeting or to long-lasting blood circulation and tumor mass was identified on a mouse model.
Journal ArticleDOI
Nanoparticles for bioimaging.
TL;DR: An overview of properties and design of contrast agents such as dye-doped silica nanoparticles, quantum dots and gold nanoparticles for non-invasive bioimaging is provided.
References
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Journal ArticleDOI
Semiconductor Nanocrystals as Fluorescent Biological Labels
TL;DR: Semiconductor nanocrystals prepared for use as fluorescent probes in biological staining and diagnostics have a narrow, tunable, symmetric emission spectrum and are photochemically stable.
Journal ArticleDOI
Quantum Dot Bioconjugates for Ultrasensitive Nonisotopic Detection
Warren C. W. Chan,Shuming Nie +1 more
TL;DR: Highly luminescent semiconductor quantum dots (zinc sulfide-capped cadmium selenide) have been covalently coupled to biomolecules for use in ultrasensitive biological detection and these nanometer-sized conjugates are water-soluble and biocompatible.
Journal Article
Long-Circulating and Target-Specific Nanoparticles: Theory to Practice
TL;DR: The surface mechanisms, which affords red blood cells long-circulatory lives and the ability of specific microorganisms to evade macrophage recognition, are explored and the rational approaches in the design as well as the biological performance of such constructs are assessed.
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Nanoparticles in cancer therapy and diagnosis
TL;DR: The in vivo fate of these systems, after intravascular or tumoral administration, is discussed, as well as the mechanism involved in tumor regression, and the application of nanoparticles in imaging for cancer diagnosis is focused on.
Journal ArticleDOI
Effect of pegylation on pharmaceuticals
J. Milton Harris,Robert B. Chess +1 more
TL;DR: How PEGylation can result in drugs that are often more effective and safer, and which show improved patient convenience and compliance are reviewed.