Journal ArticleDOI
Noninvasive Imaging of Quantum Dots in Mice
TLDR
Long-term experiments demonstrated that these quantum dots remain fluorescent after at least four months in vivo, using only quantum dots for detection.About:
This article is published in Bioconjugate Chemistry.The article was published on 2004-01-01. It has received 1153 citations till now. The article focuses on the topics: Quantum dot & Fluorescence-lifetime imaging microscopy.read more
Citations
More filters
Journal ArticleDOI
Red Emissive Biocompatible Nanoparticles from Tetraphenylethene‐Decorated BODIPY Luminogens for Two‐Photon Excited Fluorescence Cellular Imaging and Mouse Brain Blood Vascular Visualization
Zujin Zhao,Bin Chen,Junlong Geng,Zhengfeng Chang,Laura Aparicio-Ixta,Han Nie,Chi Ching Goh,Lai Guan Ng,Anjun Qin,Gabriel Ramos-Ortiz,Bin Liu,Ben Zhong Tang,Ben Zhong Tang +12 more
TL;DR: The incorporation of AIE‐active TPE units alleviates aggregation‐caused quenching of BODIPy core, furnishing emissive nanoparticles based on TPE‐BODIPY adducts that function well in TPEF cellular imaging and mouse brain blood vascular visualization.
Journal ArticleDOI
Quantum dot applications endowing novelty to analytical proteomics
TL;DR: The in‐depth application of QDs in MALDI‐MS and surface assisted laser desorption/ionization‐MS has been elaborately discussed, summarizing the speculated mechanism behind the protein–QDs interactions during QD matrix applications leading to enhanced detection sensitivity.
Journal ArticleDOI
Human health implications of nanomaterial exposure
TL;DR: The purpose of this review is to present the current state of knowledge regarding the potential routes of human exposure to nanomaterials and their biological health effects.
Journal ArticleDOI
Biodistribution of Quantum Dot Nanoparticles in Perfused Skin: Evidence of Coating Dependency and Periodicity in Arterial Extraction
Hyun A Lee,Mudassar Imran,Nancy A. Monteiro-Riviere,Vicki L Colvin,William W Yu,Jim E. Riviere +5 more
TL;DR: Both QD had a unique periodicity in arterial extraction never observed with drug infusions, suggesting a potentially important nanomaterial behavior that could affect systemic disposition.
Journal ArticleDOI
A pharmacokinetic overview of nanotechnology-based drug delivery systems: an ADME-oriented approach.
TL;DR: The purpose of the current review is to present an insightful summary of pharmacokinetic analyses of nanotechnology-based drug delivery systems along with a critical review of recent findings.
References
More filters
Journal ArticleDOI
Semiconductor Nanocrystals as Fluorescent Biological Labels
TL;DR: Semiconductor nanocrystals prepared for use as fluorescent probes in biological staining and diagnostics have a narrow, tunable, symmetric emission spectrum and are photochemically stable.
Journal ArticleDOI
Quantum Dot Bioconjugates for Ultrasensitive Nonisotopic Detection
Warren C. W. Chan,Shuming Nie +1 more
TL;DR: Highly luminescent semiconductor quantum dots (zinc sulfide-capped cadmium selenide) have been covalently coupled to biomolecules for use in ultrasensitive biological detection and these nanometer-sized conjugates are water-soluble and biocompatible.
Journal Article
Long-Circulating and Target-Specific Nanoparticles: Theory to Practice
TL;DR: The surface mechanisms, which affords red blood cells long-circulatory lives and the ability of specific microorganisms to evade macrophage recognition, are explored and the rational approaches in the design as well as the biological performance of such constructs are assessed.
Journal ArticleDOI
Nanoparticles in cancer therapy and diagnosis
TL;DR: The in vivo fate of these systems, after intravascular or tumoral administration, is discussed, as well as the mechanism involved in tumor regression, and the application of nanoparticles in imaging for cancer diagnosis is focused on.
Journal ArticleDOI
Effect of pegylation on pharmaceuticals
J. Milton Harris,Robert B. Chess +1 more
TL;DR: How PEGylation can result in drugs that are often more effective and safer, and which show improved patient convenience and compliance are reviewed.