Journal ArticleDOI
Noninvasive Imaging of Quantum Dots in Mice
TLDR
Long-term experiments demonstrated that these quantum dots remain fluorescent after at least four months in vivo, using only quantum dots for detection.About:
This article is published in Bioconjugate Chemistry.The article was published on 2004-01-01. It has received 1153 citations till now. The article focuses on the topics: Quantum dot & Fluorescence-lifetime imaging microscopy.read more
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Journal ArticleDOI
Engineering Luminescent Quantum Dots for In Vivo Molecular and Cellular Imaging
TL;DR: The engineering principles for preparing high-quality quantum dots and for conjugating the dots to biomolecular ligands are described and discusses recent advances in using quantum dots for in vivo molecular and cellular imaging.
Journal ArticleDOI
Fate and Toxicity of Metallic and Metal‐Containing Nanoparticles for Biomedical Applications
Yufeng Li,Chunying Chen +1 more
TL;DR: A summary of currently available data on the fate and toxicity of metallic or metal-containing nanoparticles based on animal studies is presented and several issues regarding the nanotoxicity assessment and future directions on the study of the fate of these nanoparticles are proposed.
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Phase transfer and its applications in nanotechnology
TL;DR: This critical review focuses on the application of phase transfer in nanoparticle synthesis, and features core-shell structures in bimetallic nanoparticles, replacement reactions in organic media, and catalytic properties of various nanostructures.
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Imaging epidermal growth factor receptor expression in vivo: pharmacokinetic and biodistribution characterization of a bioconjugated quantum dot nanoprobe.
Parmeswaran Diagaradjane,Jacobo M. Orenstein-Cardona,Norman E. Colón-Casasnovas,Amit Deorukhkar,Shujun Shentu,Norihito Kuno,David L. Schwartz,Juri G. Gelovani,Sunil Krishnan +8 more
TL;DR: The measurable contrast enhancement of tumors 4 h after systemic administration of EGF-QD and its subsequent normalization at 24 h imply that this nanoprobe may permit quantifiable and repetitive imaging of EGFR expression.
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Targeted nanoparticle-based drug delivery and diagnosis
TL;DR: The use of nanoparticles for specific intra-compartmental analysis using the examples of delivery to malignant cancers, to the central nervous system, and across the gastrointestinal barriers are highlighted.
References
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Journal ArticleDOI
Semiconductor Nanocrystals as Fluorescent Biological Labels
TL;DR: Semiconductor nanocrystals prepared for use as fluorescent probes in biological staining and diagnostics have a narrow, tunable, symmetric emission spectrum and are photochemically stable.
Journal ArticleDOI
Quantum Dot Bioconjugates for Ultrasensitive Nonisotopic Detection
Warren C. W. Chan,Shuming Nie +1 more
TL;DR: Highly luminescent semiconductor quantum dots (zinc sulfide-capped cadmium selenide) have been covalently coupled to biomolecules for use in ultrasensitive biological detection and these nanometer-sized conjugates are water-soluble and biocompatible.
Journal Article
Long-Circulating and Target-Specific Nanoparticles: Theory to Practice
TL;DR: The surface mechanisms, which affords red blood cells long-circulatory lives and the ability of specific microorganisms to evade macrophage recognition, are explored and the rational approaches in the design as well as the biological performance of such constructs are assessed.
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Nanoparticles in cancer therapy and diagnosis
TL;DR: The in vivo fate of these systems, after intravascular or tumoral administration, is discussed, as well as the mechanism involved in tumor regression, and the application of nanoparticles in imaging for cancer diagnosis is focused on.
Journal ArticleDOI
Effect of pegylation on pharmaceuticals
J. Milton Harris,Robert B. Chess +1 more
TL;DR: How PEGylation can result in drugs that are often more effective and safer, and which show improved patient convenience and compliance are reviewed.