The incidence trends of liver cirrhosis caused by nonalcoholic steatohepatitis via the GBD study 2017
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In this paper, the authors explored the incidence and distribution characteristics of NASH by sex, region and sociodemographic index (SDI), and collected data, including sex and region, on NASH-related liver cirrhosis from the 2017 GBD study.Abstract:
Nonalcoholic steatohepatitis (NASH) has rapidly become the most common cause of chronic liver diseases. We aimed to explore the incidence and distribution characteristics of NASH by sex, region and sociodemographic index (SDI). We collected data, including sex and region, on NASH-related liver cirrhosis from the 2017 GBD study. The age-standardized incidence rates (ASRs) and estimated annual percentage changes (EAPCs) were used to estimate the incidence trend and distribution characteristics. Globally, the incidence of liver cirrhosis caused by NASH increased from 178,430 cases in 1990 to 367,780 cases in 2017, an increase of approximately 105.56%. The ASR of NASH increased by an average of 1.35% per year (95% CI 1.28-1.42). Meanwhile, large differences in the ASR and the EAPC were observed across regions. The middle-high SDI region had the highest increase among all five SDI regions, followed by middle SDI region. In addition, Eastern Europe, Andean Latin America and Central Asia showed a more significant growth trend of ASR. In contrast, the high SDI region demonstrated the slowest increasing trend of ASR, and the high-income Asia Pacific demonstrated a decreasing trend among the 21 regions. Liver cirrhosis has caused a huge and rising health burden in many countries and regions. In addition, with the growth of obesity, population and aging, NASH might replace viral hepatitis as the most important cause of liver cirrhosis in the near future. Therefore, appropriate interventions are needed in coming decades to realize early diagnosis and prevention of NASH-related liver cirrhosis.read more
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TL;DR: The Global Burden of Diseases, Injuries, and Risk Factors Study 2016 (GBD 2016) provides a comprehensive assessment of prevalence, incidence, and years lived with disability (YLDs) for 328 causes in 195 countries and territories from 1990 to 2016.
Journal ArticleDOI
Global, regional, and national incidence, prevalence, andyears lived with disability for 354 diseases and injuries for195 countries and territories, 1990–2017: a systematicanalysis for the Global Burden of Disease Study 2017
Gbd Disease,Injury Incidence,Lorenzo Monasta,Luca Ronfani,Ettore Beghi,Giorgia Giussani,Boris Bikbov,Norberto Perico,Cristina Bosetti,Monica Cortinovis,Silvano Gallus,Giuseppe Remuzzi +11 more
TL;DR: All-cause age-standardised YLD rates decreased by 3·9% from 1990 to 2017; however, the all-age YLD rate increased by 7·2% while the total sum of global YLDs increased from 562 million (421–723) to 853 million (642–1100).
Journal ArticleDOI
Global epidemiology of nonalcoholic fatty liver disease—Meta‐analytic assessment of prevalence, incidence, and outcomes
Zobair M. Younossi,Zobair M. Younossi,Aaron B. Koenig,Dinan Abdelatif,Yousef Fazel,Linda Henry,Mark Wymer,Mark Wymer +7 more
TL;DR: As the global epidemic of obesity fuels metabolic conditions, the clinical and economic burden of NAFLD will become enormous, and random‐effects models were used to provide point estimates of prevalence, incidence, mortality and incidence rate ratios.
Journal ArticleDOI
Global, Regional, and National Cancer Incidence, Mortality, Years of Life Lost, Years Lived With Disability, and Disability-Adjusted Life-Years for 29 Cancer Groups, 1990 to 2016: A Systematic Analysis for the Global Burden of Disease Study.
Christina Fitzmaurice,Christina Fitzmaurice,Christina Fitzmaurice,Tomi Akinyemiju,Faris Lami,Tahiya Alam,Reza Alizadeh-Navaei,Christine Allen,Ubai Alsharif,Nelson Alvis-Guzman,Erfan Amini,Benjamin O. Anderson,Olatunde Aremu,Al Artaman,Solomon Weldegebreal Asgedom,Reza Assadi,Tesfay Mehari Atey,Leticia Avila-Burgos,Ashish Awasthi,Huda Omer Ba Saleem,Aleksandra Barac,James R. Bennett,Isabela M. Benseñor,Nickhill Bhakta,Hermann Brenner,Lucero Cahuana-Hurtado,Carlos A Castañeda-Orjuela,Ferrán Catalá-López,Ferrán Catalá-López,Jee-Young Jasmine Choi,Jee-Young Jasmine Choi,Devasahayam J. Christopher,Sheng-Chia Chung,Maria Paula Curado,Lalit Dandona,Lalit Dandona,Rakhi Dandona,Rakhi Dandona,José Neves,Subhojit Dey,Samath D Dharmaratne,David Teye Doku,David Teye Doku,Tim Driscoll,Manisha Dubey,Hedyeh Ebrahimi,Dumessa Edessa,Ziad El-Khatib,Ziad El-Khatib,Aman Yesuf Endries,Florian Fischer,Lisa M. Force,Kyle J Foreman,Kyle J Foreman,Solomon Weldemariam Gebrehiwot,Sameer Vali Gopalani,Giuseppe Grosso,Rahul Gupta,Bishal Gyawali,Randah R. Hamadeh,Samer Hamidi,James D. Harvey,Hamid Yimam Hassen,Roderick J. Hay,Simon I. Hay,Simon I. Hay,Behzad Heibati,Molla Kahssay Hiluf,Nobuyuki Horita,H. Dean Hosgood,Olayinka Stephen Ilesanmi,Kaire Innos,Farhad Islami,Mihajlo Jakovljevic,Mihajlo Jakovljevic,Sarah Charlotte Johnson,Jost B. Jonas,Amir Kasaeian,Tesfaye Dessale Kassa,Yousef Khader,Ejaz Ahmad Khan,Gulfaraz Khan,Young-Ho Khang,Young-Ho Khang,Mohammad Hossein Khosravi,Mohammad Hossein Khosravi,Jagdish Khubchandani,Jacek A. Kopec,G Anil Kumar,Michael Kutz,Deepesh Lad,Alessandra Lafranconi,Qing Lan,Yirga Legesse,James Leigh,Shai Linn,Raimundas Lunevicius,Raimundas Lunevicius,Azeem Majeed,Reza Malekzadeh,Deborah Carvalho Malta,Lorenzo G. Mantovani,Brian J. McMahon,Toni Meier,Yohannes Adama Melaku,Yohannes Adama Melaku,Mulugeta Melku,Peter Memiah,Walter Mendoza,Tuomo J. Meretoja,Haftay Berhane Mezgebe,Ted R. Miller,Ted R. Miller,Shafiu Mohammed,Shafiu Mohammed,Ali H. Mokdad,Mahmood Moosazadeh,Paula Moraga,Seyyed Meysam Mousavi,Vinay Nangia,Cuong Tat Nguyen,Vuong Minh Nong,Felix Akpojene Ogbo,Andrew T Olagunju,Andrew T Olagunju,Andrew T Olagunju,Padukudru Anand Mahesh,Eun-Kee Park,Tejas Patel,David M. Pereira,Farhad Pishgar,Maarten J. Postma,Maarten J. Postma,Farshad Pourmalek,Mostafa Qorbani,Anwar Rafay,Salman Rawaf,David Laith Rawaf,David Laith Rawaf,Gholamreza Roshandel,Gholamreza Roshandel,Saeid Safiri,Hamideh Salimzadeh,Juan Sanabria,Juan Sanabria,Milena M Santric Milicevic,Benn Sartorius,Benn Sartorius,Maheswar Satpathy,Sadaf G. Sepanlou,Katya Anne Shackelford,Masood Ali Shaikh,Mahdi Sharif-Alhoseini,Jun She,Min-Jeong Shin,Ivy Shiue,Ivy Shiue,Mark G. Shrime,Abiy Hiruye Sinke,Mekonnen Sisay,Amber Sligar,Mu'awiyyah Babale Sufiyan,Bryan L. Sykes,Rafael Tabarés-Seisdedos,Gizachew Assefa Tessema,Gizachew Assefa Tessema,Roman Topor-Madry,Roman Topor-Madry,Tung Thanh Tran,Bach Xuan Tran,Bach Xuan Tran,Kingsley N. Ukwaja,Vasiliy Victorovich Vlassov,Stein Emil Vollset,Elisabete Weiderpass,Hywel C Williams,Nigus Bililign Yimer,Naohiro Yonemoto,Mustafa Z. Younis,Christopher J L Murray,Mohsen Naghavi +180 more
TL;DR: In this paper, the authors assess the burden of 29 cancer groups over time to provide a framework for policy discussion, resource allocation, and research focus, and evaluate cancer incidence, mortality, years lived with disability, years of life lost, and disability-adjusted life-years (DALYs) for 195 countries and territories by age and sex using the Global Burden of Disease study estimation methods.
Journal ArticleDOI
The diagnosis and management of nonalcoholic fatty liver disease: Practice guidance from the American Association for the Study of Liver Diseases.
Naga Chalasani,Zobair M. Younossi,Joel E. Lavine,Michael Charlton,Kenneth Cusi,Mary E. Rinella,Stephen A. Harrison,Elizabeth M. Brunt,Arun J. Sanyal +8 more
TL;DR: This guidance provides a data-supported approach to the diagnostic, therapeutic, and preventive aspects of NAFLD care.