The intestinal microbiota: Antibiotics, colonization resistance, and enteric pathogens.
TLDR
The members of the microbiota, as well as the mechanisms, that govern colonization resistance against specific pathogens are discussed, aswell as the unique epidemiology of immunocompromised patients that renders them a particularly high‐risk population to intestinal nosocomial infections.Abstract:
The human gastrointestinal tract hosts a diverse network of microorganisms, collectively known as the microbiota that plays an important role in health and disease. For instance, the intestinal microbiota can prevent invading microbes from colonizing the gastrointestinal tract, a phenomenon known as colonization resistance. Perturbations to the microbiota, such as antibiotic administration, can alter microbial composition and result in the loss of colonization resistance. Consequently, the host may be rendered susceptible to colonization by a pathogen. This is a particularly relevant concern in the hospital setting, where antibiotic use and antibiotic-resistant pathogen exposure are more frequent. Many nosocomial infections arise from gastrointestinal colonization. Due to their resistance to antibiotics, treatment is often very challenging. However, recent studies have demonstrated that manipulating the commensal microbiota can prevent and treat various infections in the intestine. In this review, we discuss the members of the microbiota, as well as the mechanisms, that govern colonization resistance against specific pathogens. We also review the effects of antibiotics on the microbiota, as well as the unique epidemiology of immunocompromised patients that renders them a particularly high-risk population to intestinal nosocomial infections.read more
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References
More filters
Journal ArticleDOI
Molecular characterization of a functional type VI secretion system from a clinical isolate of Aeromonas hydrophila.
Giovanni Suarez,Johanna C. Sierra,Jian Sha,Shaofei Wang,Tatiana E. Erova,Amin A. Fadl,Sheri M. Foltz,Amy J. Horneman,Ashok K. Chopra +8 more
TL;DR: The vasH and vasK mutants of A. hydrophila were less virulent in a septicemic mouse model of infection, and animals immunized with recombinant Hcp were protected from subsequent challenge with the wild-type (WT) bacterium.
Journal ArticleDOI
Colonization, bloodstream infection, and mortality caused by vancomycin-resistant enterococcus early after allogeneic hematopoietic stem cell transplant.
David M. Weinstock,Mary Conlon,Christine Iovino,Tanya Aubrey,Carlota Gudiol,Elyn Riedel,James W. Young,Timothy E. Kiehn,Gianna Zuccotti +8 more
TL;DR: Stool screening effectively identified patients at extremely high risk for VRE bloodstream infection and supports the use of empiric antibiotics with activity against VRE during periods of fever and neutropenia in colonized patients.
Journal ArticleDOI
Comparative genomic analysis uncovers 3 novel loci encoding type six secretion systems differentially distributed in Salmonella serotypes
TL;DR: Comparative and phylogenetic analyses indicate that the Salmonella T6SS loci were acquired by independent lateral transfer events and evolved to contribute in the adaptation of the serotypes to different lifestyles and environments, including animal hosts.
Journal ArticleDOI
Epidemiology and Outcomes of Clostridium difficile Infections in Hematopoietic Stem Cell Transplant Recipients
Carolyn D. Alonso,Suzanne B. Treadway,David B. Hanna,Carol Ann Huff,Dionissios Neofytos,Karen C. Carroll,Kieren A. Marr +6 more
TL;DR: Early timing of CDI after HSCT suggests that the natural history of disease in some patients may involve colonization prior to HSCT, and a potentially important interplay between CDI and GVHD involving the gastrointestinal tract was observed.
Journal ArticleDOI
Loss of Microbiota-Mediated Colonization Resistance to Clostridium difficile Infection With Oral Vancomycin Compared With Metronidazole
Brittany B. Lewis,Charlie G. Buffie,Rebecca A. Carter,Ingrid Leiner,Nora C. Toussaint,Liza Miller,Asia Gobourne,Lilan Ling,Eric G. Pamer +8 more
TL;DR: Investigation of the effect of brief treatment with metronidazole and/or oral vancomycin on susceptibility to C. difficile infection in mice demonstrated that vancomYcin, and to a lesser extent metronidsazole, are associated with marked intestinal microbiota destruction and greater risk of colonization by nosocomial pathogens.
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