Journal ArticleDOI
Transcriptional regulation by Polycomb group proteins.
TLDR
The current knowledge of the PRC complexes is discussed, how they are targeted to chromatin and how the high diversity of the PcG proteins allows these complexes to influence cell identity.Abstract:
Polycomb group (PcG) proteins function within Polycomb repressive complexes (PRCs), which modify histones and other proteins and silence target genes. This Review highlights new insights into the role of PcG proteins in gene regulation, specifically in controlling self-renewal and differentiation of embryonic stem cells, and into how PRCs are targeted to chromatin.read more
Citations
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Dissertation
Exploring the role of nuclear phosphatases and their associated protein in cell growth and development
TL;DR: A yeast two-hybrid approach together with biochemical analysis was used to identify dPNUTS interacting proteins to further understand the role of PNUTS-PP1 in nuclear processes using various genetic and biochemical approaches and revealed dTOX4 is essential for fertility in female and male adult flies.
DissertationDOI
Myc-driven epigenetic memory maintains embryonic stem cell identity
TL;DR: This paper presents a meta-analysis of c-Myc-mediated transcriptional activation and repression in stem cells and cancer through the role of PcG proteins in stem cell self-renewal and its role in cancer.
Journal ArticleDOI
Role of epigenetics in cellular reprogramming; from iPSCs to disease modeling and cell therapy
Yong Li,Radbod Darabi +1 more
TL;DR: The authors discusses key features of the epigenetic process during iPSC reprogramming/differentiation and outlines important epigenetic factors that need to be considered for successful generation and differentiation of iPSCs for downstream applications.
Book ChapterDOI
Drug repurposing and nanoparticles: New strategies against leishmaniasis
TL;DR: A review of studies that looked for “old” drugs to treat leishmaniases as alternative strategies for the treatment of leish maniasis and an increasing interest in the so-called drug repurposing to address both common and rare diseases.
Book ChapterDOI
Chapter 1 – Epigenetic Regulation of Open Chromatin in Pluripotent Stem Cells
H. Kobayashi,M. Lowe,N. Kikyo +2 more
TL;DR: Describing observations and the epigenetic machinery relevant to what is supposed to be globally open chromatin in pluripotent stem cells are reviewed, revealing that the globally open Chromatin hypothesis is not necessarily supported by some of the critical experimental evidence.
References
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Journal ArticleDOI
Crystal structure of the nucleosome core particle at 2.8 Å resolution
TL;DR: The X-ray crystal structure of the nucleosome core particle of chromatin shows in atomic detail how the histone protein octamer is assembled and how 146 base pairs of DNA are organized into a superhelix around it.
Journal ArticleDOI
High-resolution profiling of histone methylations in the human genome.
Artem Barski,Suresh Cuddapah,Kairong Cui,Tae-Young Roh,Dustin E. Schones,Zhibin Wang,Gang Wei,Iouri Chepelev,Keji Zhao +8 more
TL;DR: High-resolution maps for the genome-wide distribution of 20 histone lysine and arginine methylations as well as histone variant H2A.Z, RNA polymerase II, and the insulator binding protein CTCF across the human genome using the Solexa 1G sequencing technology are generated.
Journal ArticleDOI
Functional Demarcation of Active and Silent Chromatin Domains in Human HOX Loci by Noncoding RNAs
John L. Rinn,Michael Kertesz,Jordon K. Wang,Sharon L. Squazzo,Xiao Xu,Samantha A. Brugmann,L. Henry Goodnough,Jill A. Helms,Peggy J. Farnham,Eran Segal,Howard Y. Chang +10 more
TL;DR: The transcriptional landscape of the four human HOX loci is characterized at five base pair resolution in 11 anatomic sites and 231 HOX ncRNAs are identified that extend known transcribed regions by more than 30 kilobases, suggesting transcription of ncRNA may demarcate chromosomal domains of gene silencing at a distance.
Journal ArticleDOI
A gene complex controlling segmentation in Drosophila.
TL;DR: The wild-type and mutant segmentation patterns are consistent with an antero-posterior gradient in repressor concentration along the embryo and a proximo-distal gradient along the chromosome in the affinities for repressor of each gene's cis-regulatory element.
Journal ArticleDOI
Many human large intergenic noncoding RNAs associate with chromatin-modifying complexes and affect gene expression
Ahmad M. Khalil,Mitchell Guttman,Maite Huarte,Manuel Garber,Arjun Raj,Dianali Rivea Morales,Kelly Thomas,Aviva Presser,Bradley E. Bernstein,Alexander van Oudenaarden,Aviv Regev,Eric S. Lander,John L. Rinn +12 more
TL;DR: A model in which some lincRNAs guide chromatin-modifying complexes to specific genomic loci to regulate gene expression is proposed, and it is shown that siRNA-mediated depletion of certain linc RNAs associated with PRC2 leads to changes in gene expression.