Journal ArticleDOI
Transcriptional regulation by Polycomb group proteins.
TLDR
The current knowledge of the PRC complexes is discussed, how they are targeted to chromatin and how the high diversity of the PcG proteins allows these complexes to influence cell identity.Abstract:
Polycomb group (PcG) proteins function within Polycomb repressive complexes (PRCs), which modify histones and other proteins and silence target genes. This Review highlights new insights into the role of PcG proteins in gene regulation, specifically in controlling self-renewal and differentiation of embryonic stem cells, and into how PRCs are targeted to chromatin.read more
Citations
More filters
Journal ArticleDOI
Unique features of long non-coding RNA biogenesis and function
Jeffrey J. Quinn,Howard Y. Chang +1 more
TL;DR: This Review describes special events in the lifetimes of lncRNAs — before, during and after transcription — and discusses how these events ultimately shape the unique characteristics and functional roles of lNCRNAs.
Journal ArticleDOI
Targeting EZH2 in cancer
TL;DR: A unifying perspective is synthesized that the promotion of cancer arises from disruption of the role of EZH2 as a master regulator of transcription.
Journal ArticleDOI
Cancer Epigenetics: Tumor Heterogeneity, Plasticity of Stem-like States, and Drug Resistance
TL;DR: The possible role of epigenetic abnormalities as well as genetic alterations in such dynamics and in the creation of cellular heterogeneity in cancers of all types are discussed.
Journal ArticleDOI
Interpreting the language of histone and DNA modifications
TL;DR: Key recent advances in the understanding of the epigenetic language encompassing histone and DNA modifications are highlighted and foreshadow challenges that lie ahead as the authors continue the quest to decipher the fundamental mechanisms of chromatin regulation.
Journal ArticleDOI
Transcriptional plasticity promotes primary and acquired resistance to BET inhibition
Philipp Rathert,Mareike Roth,Tobias Neumann,Felix Muerdter,Jae Seok Roe,Matthias Muhar,Sumit Deswal,Sabine Cerny-Reiterer,Barbara Peter,Julian Jude,Thomas Hoffmann,Łukasz M. Boryń,Elin Axelsson,Norbert Schweifer,Ulrike Tontsch-Grunt,Lukas E. Dow,Davide Gianni,Mark Pearson,Peter Valent,Alexander Stark,Norbert Kraut,Christopher R. Vakoc,Johannes Zuber +22 more
TL;DR: The results identify and validate WNT signalling as a driver and candidate biomarker of primary and acquired BET resistance in leukaemia, and implicate the rewiring of transcriptional programs as an important mechanism promoting resistance to BET inhibitors and, potentially, other chromatin-targeted therapies.
References
More filters
Journal ArticleDOI
Ezh2 Requires PHF1 To Efficiently Catalyze H3 Lysine 27 Trimethylation In Vivo
Kavitha Sarma,Raphaël Margueron,Alexey V. Ivanov,Vincenzo Pirrotta,Danny Reinberg,Danny Reinberg +5 more
TL;DR: PHF1 modulates the activity of Ezh2 in favor of the repressive H3K27me3 mark, proposing that PHF1 is a determinant in PcG-mediated gene repression.
Journal ArticleDOI
Polycomb group proteins Ring1A/B are functionally linked to the core transcriptional regulatory circuitry to maintain ES cell identity
Mitsuhiro Endoh,Takaho A. Endo,Tamie Endoh,Yu-ichi Fujimura,Osamu Ohara,Tetsuro Toyoda,Arie P. Otte,Masaki Okano,Neil Brockdorff,Miguel Vidal,Haruhiko Koseki +10 more
TL;DR: In this article, the authors identify an essential role for the core PRC1 components Ring1A/B in repressing developmental regulators in mouse ES cells and, thereby, in maintaining ES cell identity.
Journal ArticleDOI
Nonoverlapping Functions of the Polycomb Group Cbx Family of Proteins in Embryonic Stem Cells
Lluis Morey,Gloria Pascual,Luca Cozzuto,Guglielmo Roma,Anton Wutz,Salvador Aznar Benitah,Luciano Di Croce +6 more
TL;DR: It is shown that pluripotency and differentiation of mouse embryonic stem cells (ESCs) is regulated by different Cbx-associated PRC1 complexes with unique functions, achieving a balance between the self-renewal and the differentiation of ESCs.
Journal ArticleDOI
Polycomb Associates Genome-wide with a Specific RNA Polymerase II Variant, and Regulates Metabolic Genes in ESCs
Emily Brookes,Ines de Santiago,Daniel Hebenstreit,Kelly J. Morris,Thomas L. Carroll,Sheila Q. Xie,Julie K. Stock,Martin Heidemann,Dirk Eick,Naohito Nozaki,Hiroshi Kimura,Jiannis Ragoussis,Sarah A. Teichmann,Ana Pombo +13 more
TL;DR: This work mapped PRC repression markers and four RNAPII states in ESCs using ChIP-seq, and found that PRC targets exhibit a range ofRNAPII variants, and identifies a cohort of genes marked by PRC and elongating RNAP II (S5p+S7p+ S2p+); they produce mRNA and protein, and their expression increases upon PRC1 knockdown.
Journal ArticleDOI
Noncoding RNA and Polycomb recruitment
TL;DR: The evidence for and against this hypothesis for direct interaction between PRC2 proteins and the different ncRNAs are discussed, in the process highlighting alternative models and discussing experiments that will help to resolve existing discrepancies.