Journal ArticleDOI
Transcriptional regulation by Polycomb group proteins.
TLDR
The current knowledge of the PRC complexes is discussed, how they are targeted to chromatin and how the high diversity of the PcG proteins allows these complexes to influence cell identity.Abstract:
Polycomb group (PcG) proteins function within Polycomb repressive complexes (PRCs), which modify histones and other proteins and silence target genes. This Review highlights new insights into the role of PcG proteins in gene regulation, specifically in controlling self-renewal and differentiation of embryonic stem cells, and into how PRCs are targeted to chromatin.read more
Citations
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Journal ArticleDOI
Transcriptional enhancers and their communication with gene promoters
Helen Ray-Jones,Mikhail Spivakov +1 more
TL;DR: In this paper, the authors synthesise classic and recent evidence on the regulatory logic of enhancers, including the principles of enhancer organisation, factors that facilitate and delimit enhancer-promoter communication, and the joint effects of multiple enhancers.
Journal ArticleDOI
PCGF1 promotes epigenetic activation of stemness markers and colorectal cancer stem cell enrichment.
TL;DR: In this article, the authors identified PCGF1 as a crucial epigenetic regulator that sustains the stem cell-like phenotype of colorectal cancer (CRC) stem cells.
Posted ContentDOI
NRF1 Association with AUTS2-Polycomb Mediates Specific Gene Activation in the Brain
Sanxiong Liu,Sanxiong Liu,Kimberly A. Aldinger,Chi Vicky Cheng,Takae Kiyama,Takae Kiyama,Mitali Dave,Hanna K. McNamara,Stefano Giuseppe Caraffi,Ivan Ivanovski,Edoardo Errichiello,Christiane Zweier,Orsetta Zuffardi,Michael D. Schneider,Antigone Papavasiliou,M. Scott Perry,Megan T. Cho,Astrid Weber,Andrew Swale,Tudor C. Badea,Chai-An Mao,Chai-An Mao,Livia Garavelli,William B. Dobyns,William B. Dobyns,Danny Reinberg,Danny Reinberg +26 more
TL;DR: In this article, the authors report that patients harboring mutations in the HX repeat domain of AUTS2 exhibit defects in the P300 interaction as well as a developmental disorder reflective of Rubinstein-Taybi syndrome.
Journal ArticleDOI
AZD9291 inactivates the PRC2 complex to mediate tumor growth inhibition
TL;DR: The results suggest that AZD9291 can serve as a lead compound for further development of antagonist of PRC2 protein–protein interactions and EZH2 mRNA may be a direct target of miR-34a through non-canonical base pairing.
Journal ArticleDOI
DNA sequence models of genome-wide Drosophila melanogaster Polycomb binding sites improve generalization to independent Polycomb Response Elements
TL;DR: This work investigated whether models trained on genome-wide Polycomb sites generalize to independent PREs when trained with control sequences generated by naive PRE models and including the GTGT motif, and developed a new PRE predictor: SVM-MOCCA.
References
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Journal ArticleDOI
Crystal structure of the nucleosome core particle at 2.8 Å resolution
TL;DR: The X-ray crystal structure of the nucleosome core particle of chromatin shows in atomic detail how the histone protein octamer is assembled and how 146 base pairs of DNA are organized into a superhelix around it.
Journal ArticleDOI
High-resolution profiling of histone methylations in the human genome.
Artem Barski,Suresh Cuddapah,Kairong Cui,Tae-Young Roh,Dustin E. Schones,Zhibin Wang,Gang Wei,Iouri Chepelev,Keji Zhao +8 more
TL;DR: High-resolution maps for the genome-wide distribution of 20 histone lysine and arginine methylations as well as histone variant H2A.Z, RNA polymerase II, and the insulator binding protein CTCF across the human genome using the Solexa 1G sequencing technology are generated.
Journal ArticleDOI
Functional Demarcation of Active and Silent Chromatin Domains in Human HOX Loci by Noncoding RNAs
John L. Rinn,Michael Kertesz,Jordon K. Wang,Sharon L. Squazzo,Xiao Xu,Samantha A. Brugmann,L. Henry Goodnough,Jill A. Helms,Peggy J. Farnham,Eran Segal,Howard Y. Chang +10 more
TL;DR: The transcriptional landscape of the four human HOX loci is characterized at five base pair resolution in 11 anatomic sites and 231 HOX ncRNAs are identified that extend known transcribed regions by more than 30 kilobases, suggesting transcription of ncRNA may demarcate chromosomal domains of gene silencing at a distance.
Journal ArticleDOI
A gene complex controlling segmentation in Drosophila.
TL;DR: The wild-type and mutant segmentation patterns are consistent with an antero-posterior gradient in repressor concentration along the embryo and a proximo-distal gradient along the chromosome in the affinities for repressor of each gene's cis-regulatory element.
Journal ArticleDOI
Many human large intergenic noncoding RNAs associate with chromatin-modifying complexes and affect gene expression
Ahmad M. Khalil,Mitchell Guttman,Maite Huarte,Manuel Garber,Arjun Raj,Dianali Rivea Morales,Kelly Thomas,Aviva Presser,Bradley E. Bernstein,Alexander van Oudenaarden,Aviv Regev,Eric S. Lander,John L. Rinn +12 more
TL;DR: A model in which some lincRNAs guide chromatin-modifying complexes to specific genomic loci to regulate gene expression is proposed, and it is shown that siRNA-mediated depletion of certain linc RNAs associated with PRC2 leads to changes in gene expression.