Journal ArticleDOI
Transcriptional regulation by Polycomb group proteins.
TLDR
The current knowledge of the PRC complexes is discussed, how they are targeted to chromatin and how the high diversity of the PcG proteins allows these complexes to influence cell identity.Abstract:
Polycomb group (PcG) proteins function within Polycomb repressive complexes (PRCs), which modify histones and other proteins and silence target genes. This Review highlights new insights into the role of PcG proteins in gene regulation, specifically in controlling self-renewal and differentiation of embryonic stem cells, and into how PRCs are targeted to chromatin.read more
Citations
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Targeting EZH2 and PRC2 dependence as novel anticancer therapy.
TL;DR: Concerns over potentially toxic or even adverse effects associated with EZH2/1 inhibition in certain biological contexts or on cancer genetic background are discussed.
Journal ArticleDOI
Regulation of Genome Architecture and Function by Polycomb Proteins
TL;DR: This review discusses recent advances in understanding of how PcG proteins are recruited to chromatin to induce local and global changes in chromosome conformation and regulate their target genes.
Journal ArticleDOI
BMI1-RING1B is an autoinhibited RING E3 ubiquitin ligase
TL;DR: The intrinsically low activity of the PCGF4-RING1B heterodimer is offset by a relatively favourable interaction with nucleosome substrates, resulting in an efficient site-specific monoubiquitination in BMI1/PCGF4.
Journal ArticleDOI
The role of epigenetics and long noncoding RNA MIAT in neuroendocrine prostate cancer
Francesco Crea,Francesco Crea,Erik Venalainen,Xinpei Ci,Xinpei Ci,Hongwei Cheng,Hongwei Cheng,Larissa Pikor,Abhijit Parolia,Hui Xue,Nur Ridzwan Nur Saidy,Dong Lin,Dong Lin,Wan L. Lam,Colin Collins,Yuzhuo Wang,Yuzhuo Wang +16 more
TL;DR: Evidence indicating that some components of the ENI (Polycomb genes, miRNAs) play a key role in NEPC initiation and progression is discussed, and results indicate that long noncoding RNAs can be exploited as new biomarkers and therapeutic targets for NEPC.
Journal ArticleDOI
Bmi-1: At the crossroads of physiological and pathological biology.
Resham Bhattacharya,Soumyajit Banerjee Mustafi,Mark Street,Anindya Dey,Shailendra Kumar Dhar Dwivedi +4 more
TL;DR: This review attempts to synthesize the current knowledge on Bmi-1 with an emphasis on its role in both normal physiology and cancer, and since cancer stem cells are emerging as a new paradigm for therapy resistance, the role of Bmi1 in this perspective is highlighted.
References
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Journal ArticleDOI
Crystal structure of the nucleosome core particle at 2.8 Å resolution
TL;DR: The X-ray crystal structure of the nucleosome core particle of chromatin shows in atomic detail how the histone protein octamer is assembled and how 146 base pairs of DNA are organized into a superhelix around it.
Journal ArticleDOI
High-resolution profiling of histone methylations in the human genome.
Artem Barski,Suresh Cuddapah,Kairong Cui,Tae-Young Roh,Dustin E. Schones,Zhibin Wang,Gang Wei,Iouri Chepelev,Keji Zhao +8 more
TL;DR: High-resolution maps for the genome-wide distribution of 20 histone lysine and arginine methylations as well as histone variant H2A.Z, RNA polymerase II, and the insulator binding protein CTCF across the human genome using the Solexa 1G sequencing technology are generated.
Journal ArticleDOI
Functional Demarcation of Active and Silent Chromatin Domains in Human HOX Loci by Noncoding RNAs
John L. Rinn,Michael Kertesz,Jordon K. Wang,Sharon L. Squazzo,Xiao Xu,Samantha A. Brugmann,L. Henry Goodnough,Jill A. Helms,Peggy J. Farnham,Eran Segal,Howard Y. Chang +10 more
TL;DR: The transcriptional landscape of the four human HOX loci is characterized at five base pair resolution in 11 anatomic sites and 231 HOX ncRNAs are identified that extend known transcribed regions by more than 30 kilobases, suggesting transcription of ncRNA may demarcate chromosomal domains of gene silencing at a distance.
Journal ArticleDOI
A gene complex controlling segmentation in Drosophila.
TL;DR: The wild-type and mutant segmentation patterns are consistent with an antero-posterior gradient in repressor concentration along the embryo and a proximo-distal gradient along the chromosome in the affinities for repressor of each gene's cis-regulatory element.
Journal ArticleDOI
Many human large intergenic noncoding RNAs associate with chromatin-modifying complexes and affect gene expression
Ahmad M. Khalil,Mitchell Guttman,Maite Huarte,Manuel Garber,Arjun Raj,Dianali Rivea Morales,Kelly Thomas,Aviva Presser,Bradley E. Bernstein,Alexander van Oudenaarden,Aviv Regev,Eric S. Lander,John L. Rinn +12 more
TL;DR: A model in which some lincRNAs guide chromatin-modifying complexes to specific genomic loci to regulate gene expression is proposed, and it is shown that siRNA-mediated depletion of certain linc RNAs associated with PRC2 leads to changes in gene expression.