Journal ArticleDOI
Transcriptional regulation by Polycomb group proteins.
TLDR
The current knowledge of the PRC complexes is discussed, how they are targeted to chromatin and how the high diversity of the PcG proteins allows these complexes to influence cell identity.Abstract:
Polycomb group (PcG) proteins function within Polycomb repressive complexes (PRCs), which modify histones and other proteins and silence target genes. This Review highlights new insights into the role of PcG proteins in gene regulation, specifically in controlling self-renewal and differentiation of embryonic stem cells, and into how PRCs are targeted to chromatin.read more
Citations
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Journal ArticleDOI
LINC02678 as a Novel Prognostic Marker Promotes Aggressive Non-small-cell Lung Cancer.
Dexin Jia,Ying Xing,Yuning Zhan,Mengru Cao,Fanglin Tian,Weina Fan,Jian Huang,Yimeng Cui,Ruixue Gu,Yaowen Cui,Yuechao Liu,Shuai Zhang,Li Cai,Xiaomei Li +13 more
TL;DR: It is found that LINC02678 knockdown impaired the occupancy capacity of EZH2 and trimethylation of lysine 27 on histone 3 at the promoter region of cyclin dependent kinase inhibitor 1B (CDKN1B) and E-cadherin, as confirmed by ChIP-qPCR.
Journal ArticleDOI
Epigenetic and transcriptional regulation of GnRH gene under altered metabolism and ageing
TL;DR: The role of epigenetics and environmental factors triggering the regulatory network of the 5' promoter and enhancer region of the GnRH-I gene has been investigated in this article.
Posted ContentDOI
Learning the human chromatin network from all ENCODE ChIP-seq data
TL;DR: Ch ChromNet provides a useful tool for understanding the interactions among regulatory factors and identifying novel interactions and provides an efficient way to identify the genomic context that drives a particular network edge, which provides a more comprehensive understanding of regulatory factor interactions.
Book ChapterDOI
The Emerging Epigenetic Landscape in Melanoma
TL;DR: This chapter provides a comprehensive review of the epigenetic alterations in melanoma and highlights the roles played by specific chromatin regulators during disease progression, placing emphasis on the potential to overcome resistance to targeted therapies and to serve as priming agents for immunotherapies.
Journal ArticleDOI
Peritoneal Modulators of Endometriosis-Associated Ovarian Cancer
Sarah Brunty,Lauren Clower,Brenda L Mitchell,Taylor Fleshman,Nadim Bou Zgheib,Nalini Santanam +5 more
TL;DR: In this article, peritoneal fluid (PF) from women with and without endometriosis was collected after IRB approval and patient consent, and a Human Cancer Inflammation and Immunity Crosstalk RT2 Profiler PCR array was used to measure changes in cancer related genes in treated cells.
References
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Journal ArticleDOI
Crystal structure of the nucleosome core particle at 2.8 Å resolution
TL;DR: The X-ray crystal structure of the nucleosome core particle of chromatin shows in atomic detail how the histone protein octamer is assembled and how 146 base pairs of DNA are organized into a superhelix around it.
Journal ArticleDOI
High-resolution profiling of histone methylations in the human genome.
Artem Barski,Suresh Cuddapah,Kairong Cui,Tae-Young Roh,Dustin E. Schones,Zhibin Wang,Gang Wei,Iouri Chepelev,Keji Zhao +8 more
TL;DR: High-resolution maps for the genome-wide distribution of 20 histone lysine and arginine methylations as well as histone variant H2A.Z, RNA polymerase II, and the insulator binding protein CTCF across the human genome using the Solexa 1G sequencing technology are generated.
Journal ArticleDOI
Functional Demarcation of Active and Silent Chromatin Domains in Human HOX Loci by Noncoding RNAs
John L. Rinn,Michael Kertesz,Jordon K. Wang,Sharon L. Squazzo,Xiao Xu,Samantha A. Brugmann,L. Henry Goodnough,Jill A. Helms,Peggy J. Farnham,Eran Segal,Howard Y. Chang +10 more
TL;DR: The transcriptional landscape of the four human HOX loci is characterized at five base pair resolution in 11 anatomic sites and 231 HOX ncRNAs are identified that extend known transcribed regions by more than 30 kilobases, suggesting transcription of ncRNA may demarcate chromosomal domains of gene silencing at a distance.
Journal ArticleDOI
A gene complex controlling segmentation in Drosophila.
TL;DR: The wild-type and mutant segmentation patterns are consistent with an antero-posterior gradient in repressor concentration along the embryo and a proximo-distal gradient along the chromosome in the affinities for repressor of each gene's cis-regulatory element.
Journal ArticleDOI
Many human large intergenic noncoding RNAs associate with chromatin-modifying complexes and affect gene expression
Ahmad M. Khalil,Mitchell Guttman,Maite Huarte,Manuel Garber,Arjun Raj,Dianali Rivea Morales,Kelly Thomas,Aviva Presser,Bradley E. Bernstein,Alexander van Oudenaarden,Aviv Regev,Eric S. Lander,John L. Rinn +12 more
TL;DR: A model in which some lincRNAs guide chromatin-modifying complexes to specific genomic loci to regulate gene expression is proposed, and it is shown that siRNA-mediated depletion of certain linc RNAs associated with PRC2 leads to changes in gene expression.