Journal ArticleDOI
Transcriptional regulation by Polycomb group proteins.
TLDR
The current knowledge of the PRC complexes is discussed, how they are targeted to chromatin and how the high diversity of the PcG proteins allows these complexes to influence cell identity.Abstract:
Polycomb group (PcG) proteins function within Polycomb repressive complexes (PRCs), which modify histones and other proteins and silence target genes. This Review highlights new insights into the role of PcG proteins in gene regulation, specifically in controlling self-renewal and differentiation of embryonic stem cells, and into how PRCs are targeted to chromatin.read more
Citations
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Investigating the epi-miRNome: identification of epi-miRNAs using transfection experiments.
Elisa Reale,Daniela Taverna,Laura Cantini,Laura Cantini,Loredana Martignetti,Matteo Osella,Cristiano De Pittà,Federico Virga,Francesca Orso,Michele Caselle +9 more
TL;DR: A pipeline is proposed to prioritize candidate epi-miRs and to identify potential epigenetic interactors of any given miR starting from miR transfection experiment datasets, and it is experimentally proved that a component of the polycomb-repressive complex 2, the histone methyltransferase enhancer of zeste homolog 2 (EZH2), interacts with miR-214, a well-known prometastatic miR in melanoma and breast cancer.
Journal ArticleDOI
Detection of MEAF6-PHF1 translocation in an endometrial stromal nodule
Yusuke Nomura,Daisuke Tamura,Masafumi Horie,Masakazu Sato,Shinya Sasaki,Yohei Yamamoto,Yukitsugu Kudo-Asabe,Michinobu Umakoshi,Kei Koyama,Kenichi Makino,Shinogu Takashima,Kazuhiro Imai,Yoshihiro Minamiya,Satoru Munakata,Shinichi Yachida,Yukihiro Terada,Akiteru Goto,Daichi Maeda +17 more
TL;DR: The finding that MEAF6‐PHF1 fusion is a background genetic abnormality detected both in ESN and LG‐ESS, along with JAZF1‐SUZ12, provides further support for the similarity and continuum between these two types of ESTs.
Journal ArticleDOI
Epigenetic, Metabolic, and Immune Crosstalk in Germinal-Center-Derived B-Cell Lymphomas: Unveiling New Vulnerabilities for Rational Combination Therapies
Inna Serganova,Sanjukta Chakraborty,Samuel Yamshon,Yusuke Isshiki,R. Bucktrout,Ari Melnick,Wendy Béguelin,Roberta Zappasodi +7 more
TL;DR: New insights are provided on how the epigenetic program of these diseases may be regulated at the level of metabolism, discussing the role of metabolic intermediates as cofactors of epigenetic enzymes.
Journal ArticleDOI
Myeloid Ezh2 Deficiency Limits Atherosclerosis Development
Annette E. Neele,Hung-Jen Chen,Marion J.J. Gijbels,Marion J.J. Gijbels,Saskia van der Velden,Marten A. Hoeksema,Marten A. Hoeksema,Marieke C.S. Boshuizen,Jan Van den Bossche,Jan Van den Bossche,Anton Tj Tool,Hanke L. Matlung,Timo K. van den Berg,Esther Lutgens,Esther Lutgens,Menno P.J. de Winther +15 more
TL;DR: In this paper, the role of myeloid EZH2 deficiency in atherosclerosis was studied and it was shown that deletion of KDM6b, an enzymes that in contrast to EZh2 removes repressive histone H3K27me3 marks, results in advanced atheros sclerosis.
Journal ArticleDOI
YY1 binds to the E3' enhancer and inhibits the expression of the immunoglobulin κ gene via epigenetic modifications.
Xiaorong Zhou,Weiwei Xian,Jie Zhang,Yiqing Zhu,Xiaoyi Shao,Yu Han,Yue Qi,Xiaoling Ding,Xiaoying Wang +8 more
TL;DR: It is found that YY1 binds to the E3ʹ enhancer and suppresses Igκ expression in B lymphoma cells by epigenetically modifying the enhancer.
References
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Journal ArticleDOI
Crystal structure of the nucleosome core particle at 2.8 Å resolution
TL;DR: The X-ray crystal structure of the nucleosome core particle of chromatin shows in atomic detail how the histone protein octamer is assembled and how 146 base pairs of DNA are organized into a superhelix around it.
Journal ArticleDOI
High-resolution profiling of histone methylations in the human genome.
Artem Barski,Suresh Cuddapah,Kairong Cui,Tae-Young Roh,Dustin E. Schones,Zhibin Wang,Gang Wei,Iouri Chepelev,Keji Zhao +8 more
TL;DR: High-resolution maps for the genome-wide distribution of 20 histone lysine and arginine methylations as well as histone variant H2A.Z, RNA polymerase II, and the insulator binding protein CTCF across the human genome using the Solexa 1G sequencing technology are generated.
Journal ArticleDOI
Functional Demarcation of Active and Silent Chromatin Domains in Human HOX Loci by Noncoding RNAs
John L. Rinn,Michael Kertesz,Jordon K. Wang,Sharon L. Squazzo,Xiao Xu,Samantha A. Brugmann,L. Henry Goodnough,Jill A. Helms,Peggy J. Farnham,Eran Segal,Howard Y. Chang +10 more
TL;DR: The transcriptional landscape of the four human HOX loci is characterized at five base pair resolution in 11 anatomic sites and 231 HOX ncRNAs are identified that extend known transcribed regions by more than 30 kilobases, suggesting transcription of ncRNA may demarcate chromosomal domains of gene silencing at a distance.
Journal ArticleDOI
A gene complex controlling segmentation in Drosophila.
TL;DR: The wild-type and mutant segmentation patterns are consistent with an antero-posterior gradient in repressor concentration along the embryo and a proximo-distal gradient along the chromosome in the affinities for repressor of each gene's cis-regulatory element.
Journal ArticleDOI
Many human large intergenic noncoding RNAs associate with chromatin-modifying complexes and affect gene expression
Ahmad M. Khalil,Mitchell Guttman,Maite Huarte,Manuel Garber,Arjun Raj,Dianali Rivea Morales,Kelly Thomas,Aviva Presser,Bradley E. Bernstein,Alexander van Oudenaarden,Aviv Regev,Eric S. Lander,John L. Rinn +12 more
TL;DR: A model in which some lincRNAs guide chromatin-modifying complexes to specific genomic loci to regulate gene expression is proposed, and it is shown that siRNA-mediated depletion of certain linc RNAs associated with PRC2 leads to changes in gene expression.