Journal ArticleDOI
Transcriptional regulation by Polycomb group proteins.
TLDR
The current knowledge of the PRC complexes is discussed, how they are targeted to chromatin and how the high diversity of the PcG proteins allows these complexes to influence cell identity.Abstract:
Polycomb group (PcG) proteins function within Polycomb repressive complexes (PRCs), which modify histones and other proteins and silence target genes. This Review highlights new insights into the role of PcG proteins in gene regulation, specifically in controlling self-renewal and differentiation of embryonic stem cells, and into how PRCs are targeted to chromatin.read more
Citations
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Journal ArticleDOI
Inhibition of EZH2 and activation of ERRγ synergistically suppresses gastric cancer by inhibiting FOXM1 signaling pathway
Boyan Huang,Peiqiang Mu,Yan Yu,Wenya Zhu,Tianqing Jiang,Rong Deng,Gong-Kan Feng,Jikai Wen,Xiao Feng Zhu,Yiqun Deng +9 more
TL;DR: Combined treatment with EZH2 inhibitor and ERRγ agonist synergistically suppressed GC progression by inhibiting this signaling pathway, suggesting its high potential in treating GC patients.
Journal ArticleDOI
Bmi1 limits dilated cardiomyopathy and heart failure by inhibiting cardiac senescence
I. Gonzalez-Valdes,I. Hidalgo,A. Bujarrabal,Enrique Lara-Pezzi,Laura Padron-Barthe,Pablo García-Pavía,P. Gomez,Juan Miguel Redondo,Jesús Ruiz-Cabello,Luis Jesús Jiménez-Borreguero,José Antonio Enríquez,J.L. de la Pompa,Andrés Hidalgo,Susana González +13 more
TL;DR: It is shown that epigenetic regulator and central transcriptional instructor in adult stem cells, Bmi1, protects against DCM by repressing cardiac senescence, suggesting a source for cardiac rejuvenation.
Journal ArticleDOI
Stem cell fate determination through protein O-GlcNAcylation.
TL;DR: Evidence demonstrating how stem cells couple metabolic inputs to gene regulatory pathways through O-GlcNAc-mediated epigenetic/transcriptional regulatory mechanisms to govern self-renewal and lineage-specific differentiation programs is reviewed.
Journal ArticleDOI
Persistent Requirement and Alteration of the Key Targets of PRDM1 During Primordial Germ Cell Development in Mice
Chika Yamashiro,Takayuki Hirota,Takayuki Hirota,Kazuki Kurimoto,Kazuki Kurimoto,Tomonori Nakamura,Tomonori Nakamura,Yukihiro Yabuta,Yukihiro Yabuta,So I. Nagaoka,Hiroshi Ohta,Hiroshi Ohta,Takuya Yamamoto,Mitinori Saitou +13 more
TL;DR: It is shown here that PRDM1 is critically required throughout PGC development, and the escape of a fraction of PGCs from the Prdm1 deletion was sufficient to recover fairly normal germ cell pools, both in male and female adults.
Journal ArticleDOI
SMARCB1-Deficient Sinonasal Carcinoma: A Case Report and Discussion of the Clinical Implications.
TL;DR: Tumor necrosis may be problematic in obtaining a diagnosis for SMARCB1-deficient sinonasal tract carcinomas, so sampling various regions of the tumor during initial biopsy can prevent delays in diagnosis and treatment.
References
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Journal ArticleDOI
Crystal structure of the nucleosome core particle at 2.8 Å resolution
TL;DR: The X-ray crystal structure of the nucleosome core particle of chromatin shows in atomic detail how the histone protein octamer is assembled and how 146 base pairs of DNA are organized into a superhelix around it.
Journal ArticleDOI
High-resolution profiling of histone methylations in the human genome.
Artem Barski,Suresh Cuddapah,Kairong Cui,Tae-Young Roh,Dustin E. Schones,Zhibin Wang,Gang Wei,Iouri Chepelev,Keji Zhao +8 more
TL;DR: High-resolution maps for the genome-wide distribution of 20 histone lysine and arginine methylations as well as histone variant H2A.Z, RNA polymerase II, and the insulator binding protein CTCF across the human genome using the Solexa 1G sequencing technology are generated.
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Functional Demarcation of Active and Silent Chromatin Domains in Human HOX Loci by Noncoding RNAs
John L. Rinn,Michael Kertesz,Jordon K. Wang,Sharon L. Squazzo,Xiao Xu,Samantha A. Brugmann,L. Henry Goodnough,Jill A. Helms,Peggy J. Farnham,Eran Segal,Howard Y. Chang +10 more
TL;DR: The transcriptional landscape of the four human HOX loci is characterized at five base pair resolution in 11 anatomic sites and 231 HOX ncRNAs are identified that extend known transcribed regions by more than 30 kilobases, suggesting transcription of ncRNA may demarcate chromosomal domains of gene silencing at a distance.
Journal ArticleDOI
A gene complex controlling segmentation in Drosophila.
TL;DR: The wild-type and mutant segmentation patterns are consistent with an antero-posterior gradient in repressor concentration along the embryo and a proximo-distal gradient along the chromosome in the affinities for repressor of each gene's cis-regulatory element.
Journal ArticleDOI
Many human large intergenic noncoding RNAs associate with chromatin-modifying complexes and affect gene expression
Ahmad M. Khalil,Mitchell Guttman,Maite Huarte,Manuel Garber,Arjun Raj,Dianali Rivea Morales,Kelly Thomas,Aviva Presser,Bradley E. Bernstein,Alexander van Oudenaarden,Aviv Regev,Eric S. Lander,John L. Rinn +12 more
TL;DR: A model in which some lincRNAs guide chromatin-modifying complexes to specific genomic loci to regulate gene expression is proposed, and it is shown that siRNA-mediated depletion of certain linc RNAs associated with PRC2 leads to changes in gene expression.