Guidelines and recommendations on yeast cell death nomenclature
Didac Carmona-Gutierrez,Maria A. Bauer,Andreas Zimmermann,Andrés Aguilera,Nicanor Austriaco,Kathryn R. Ayscough,Rena Balzan,Shoshana Bar-Nun,Antonio Barrientos,Peter Belenky,Marc Blondel,Ralf J. Braun,Michael Breitenbach,William Wc Burhans,Sabrina Büttner,Sabrina Büttner,Duccio Cavalieri,Michael Chang,Katrina Kf Cooper,Manuela Côrte-Real,Vítor Costa,Vítor Costa,Christophe Cullin,Ian W. Dawes,Jörn Dengjel,Martin Mb Dickman,Tobias Eisenberg,Birthe Fahrenkrog,Nicolas Fasel,Kai-Uwe Fröhlich,Ali Gargouri,Sergio Giannattasio,Paola Goffrini,Campbell W. Gourlay,Chris M. Grant,Michael Mt Greenwood,Nicoletta Guaragnella,Thomas Heger,Jürgen J. Heinisch,Eva Herker,Johannes M. Herrmann,Sebastian J. Hofer,Antonio Jiménez-Ruiz,Helmut Jungwirth,Katharina Kainz,Dimitrios P. Kontoyiannis,Paula Ludovico,Paula Ludovico,Stéphen Manon,Enzo Martegani,Cristina Mazzoni,Lynn La Megeney,Lynn La Megeney,Christa Meisinger,Jens Nielsen,Jens Nielsen,Thomas Nyström,Heinz Hd Osiewacz,Tiago Tf Outeiro,Hay-Oak Park,Tobias Pendl,Dina Petranovic,Stéphane Picot,Peter Polčic,Ted Powers,Mark Ramsdale,Mark Rinnerthaler,Patrick Rockenfeller,Patrick Rockenfeller,Christoph Ruckenstuhl,Raffael Schaffrath,María Segovia,Fedor Ff Severin,Amir Sharon,Stephan J. Sigrist,Cornelia Sommer-Ruck,Maria João Sousa,Johan Jm Thevelein,Karin Thevissen,Vladimir I. Titorenko,Michel Mb Toledano,Mick F. Tuite,F-Nora Vögtle,Benedikt Westermann,Joris Winderickx,Silke Wissing,Stefan Wölfl,Zhaojie J Zhang,Richard Y. Zhao,Bing Zhou,Lorenzo Galluzzi,Lorenzo Galluzzi,Guido Kroemer,Frank Madeo +93 more
TLDR
Unified criteria for the definition of accidental, regulated, and programmed forms of cell death in yeast based on a series of morphological and biochemical criteria are proposed.Abstract:
Elucidating the biology of yeast in its full complexity has major implications for science, medicine and industry. One of the most critical processes determining yeast life and physiology is cel-lular demise. However, the investigation of yeast cell death is a relatively young field, and a widely accepted set of concepts and terms is still missing. Here, we propose unified criteria for the defi-nition of accidental, regulated, and programmed forms of cell death in yeast based on a series of morphological and biochemical criteria. Specifically, we provide consensus guidelines on the differ-ential definition of terms including apoptosis, regulated necrosis, and autophagic cell death, as we refer to additional cell death rou-tines that are relevant for the biology of (at least some species of) yeast. As this area of investigation advances rapidly, changes and extensions to this set of recommendations will be implemented in the years to come. Nonetheless, we strongly encourage the au-thors, reviewers and editors of scientific articles to adopt these collective standards in order to establish an accurate framework for yeast cell death research and, ultimately, to accelerate the pro-gress of this vibrant field of research.read more
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Caloric Restriction Mimetics against Age-Associated Disease: Targets, Mechanisms, and Therapeutic Potential
TL;DR: Current knowledge on molecular, cellular, and organismal effects of known and putative CRMs in mice and humans are described and it is anticipated that CRMs will become part of the pharmacological armamentarium against aging and age-related cardiovascular, neurodegenerative, and malignant diseases.
Guidelines for the use and interpretatoin of assays for monitoring autophagy
D. J. Klionsky,F. C. Abdalla,H. Abeliovich,R. T. Abraham,A. Acevedo-Arozena,K. Adeli,L. Agholme,M. Agnello,A. M. Engelbrecht,B. Loos +9 more
TL;DR: In this paper, the authors present a set of guidelines for the selection and interpretation of methods for use by investigators who aim to examine macro-autophagy and related processes, as well as for reviewers who need to provide realistic and reasonable critiques of papers that are focused on these processes.
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The flavonoid 4,4′-dimethoxychalcone promotes autophagy-dependent longevity across species
Didac Carmona-Gutierrez,Andreas Zimmermann,Andreas Zimmermann,Katharina Kainz,Federico Pietrocola,Guo Chen,Silvia Maglioni,Alfonso Schiavi,Jihoon Nah,Sara Mertel,Christine B. Beuschel,Francesca Castoldi,Valentina Sica,Gert Trausinger,Reingard Raml,Cornelia Sommer,Sabrina Schroeder,Sebastian J. Hofer,Maria A. Bauer,Tobias Pendl,Jelena Tadic,Christopher Dammbrueck,Zehan Hu,Christoph Ruckenstuhl,Tobias Eisenberg,Sylvère Durand,Sylvère Durand,Noélie Bossut,Noélie Bossut,Fanny Aprahamian,Fanny Aprahamian,Mahmoud Abdellatif,Simon Sedej,David Enot,David Enot,Heimo Wolinski,Jörn Dengjel,Oliver Kepp,Christoph Magnes,Frank Sinner,Frank Sinner,Thomas R. Pieber,Thomas R. Pieber,Junichi Sadoshima,Natascia Ventura,Stephan J. Sigrist,Stephan J. Sigrist,Guido Kroemer,Frank Madeo +48 more
TL;DR: It is demonstrated that DMC extends lifespan and promotes health in multiple organisms by inducing autophagy and is identified in the plant Angelica keiskei koidzumi, to which longevity- and health-promoting effects are ascribed in Asian traditional medicine.
Journal ArticleDOI
Methodologies for in vitro and in vivo evaluation of efficacy of antifungal and antibiofilm agents and surface coatings against fungal biofilms
Patrick Van Dijck,Jelmer Sjollema,Bruno P. A. Cammue,Katrien Lagrou,Judith Berman,Christophe d'Enfert,David R. Andes,Maiken Cavling Arendrup,Maiken Cavling Arendrup,Axel A. Brakhage,Richard Calderone,Emilia Cantón,Tom Coenye,Paul Cos,Leah E. Cowen,Mira Edgerton,Ana Espinel-Ingroff,Scott G. Filler,Mahmoud A. Ghannoum,Neil A. R. Gow,Hubertus Haas,Mary Ann Jabra-Rizk,Elizabeth M. Johnson,Shawn R. Lockhart,Jose L. Lopez-Ribot,Johan Maertens,Carol A. Munro,Jeniel E. Nett,Clarissa J. Nobile,Michael A. Pfaller,Gordon Ramage,Dominique Sanglard,Maurizio Sanguinetti,Isabel Spriet,Paul E. Verweij,Adilia Warris,Joost Wauters,Michael R. Yeaman,Sebastian A. J. Zaat,Karin Thevissen +39 more
TL;DR: An overview of the methods currently available for determining the susceptibility or resistance of fungal isolates or biofilms to antifungal or antibiofilm compounds and compound combinations and the in vitro and in vivo performance of anti-infective coatings and materials to prevent fungal biofilm-based infections is presented.
Journal ArticleDOI
Yeast as a tool to identify anti-aging compounds.
Andreas Zimmermann,Sebastian J. Hofer,Tobias Pendl,Katharina Kainz,Frank Madeo,Didac Carmona-Gutierrez +5 more
TL;DR: Strategies for pharmacological anti-aging screens in yeast are presented, common pitfalls are discussed and studies that have used yeast for drug discovery and target identification are summarized.
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TL;DR: The Nomenclature Committee on Cell Death (NCCD) has formulated guidelines for the definition and interpretation of cell death from morphological, biochemical, and functional perspectives.
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TL;DR: It appears that some checkpoints are eliminated during the early embryonic development of some organisms; this fact may pose special problems for the fidelity of embryonic cell division.
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Seamus J. Martin,Chris P. M. Reutelingsperger,A J McGahon,J. A. Rader,R. C. A. A. Van Schie,Drake LaFace,Douglas R. Green +6 more
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