C
Carla A. Ibrahim-Verbaas
Researcher at Erasmus University Rotterdam
Publications - 32
Citations - 10307
Carla A. Ibrahim-Verbaas is an academic researcher from Erasmus University Rotterdam. The author has contributed to research in topics: Genome-wide association study & Population. The author has an hindex of 24, co-authored 32 publications receiving 8955 citations. Previous affiliations of Carla A. Ibrahim-Verbaas include Radboud University Nijmegen Medical Centre & Harvard University.
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Journal ArticleDOI
A novel Alzheimer disease locus located near the gene encoding tau protein
Gyungah Jun,Carla A. Ibrahim-Verbaas,Maria Vronskaya,J-C Lambert,J-C Lambert,J-C Lambert,Jaeyoon Chung,Adam C. Naj,Brian W. Kunkle,L-S Wang,J. C. Bis,Céline Bellenguez,Céline Bellenguez,Céline Bellenguez,Denise Harold,K. L. Lunetta,Anita L. DeStefano,Benjamin Grenier-Boley,Benjamin Grenier-Boley,Benjamin Grenier-Boley,Rebecca Sims,Gary W. Beecham,Albert V. Smith,Vincent Chouraki,Kara L. Hamilton-Nelson,M. A. Ikram,Nathalie Fievet,Nathalie Fievet,Nathalie Fievet,Nicola Denning,Eden R. Martin,Helena Schmidt,Yoichiro Kamatani,Melanie L. Dunstan,Otto Valladares,A R Laza,Diana Zelenika,Alfredo Ramirez,Tatiana Foroud,S-H Choi,Anne Boland,Tim Becker,Tim Becker,Walter A. Kukull,S. J. van der Lee,Florence Pasquier,C. Cruchaga,Duane Beekly,Annette L. Fitzpatrick,O. Hanon,Michael Gill,Robert Barber,Vilmundur Gudnason,D. Campion,Seth Love,David A. Bennett,Najaf Amin,Claudine Berr,Magda Tsolaki,Joseph D. Buxbaum,O. L. Lopez,Vincent Deramecourt,Nick C. Fox,Laura B. Cantwell,L. Tárraga,Carole Dufouil,J. Hardy,J. Hardy,Paul K. Crane,G. Eiriksdottir,Didier Hannequin,Robert Clarke,Denis A. Evans,Thomas H. Mosley,Luc Letenneur,Carol Brayne,W. Maier,W. Maier,P. L. De Jager,P. L. De Jager,P. L. De Jager,Valur Emilsson,J. F. Dartigues,J. F. Dartigues,Harald Hampel,Harald Hampel,Kamboh Mi,R. F. A. G. de Bruijn,Christophe Tzourio,Pau Pastor,Eric B. Larson,Eric B. Larson,Jerome I. Rotter,Michael Conlon O'Donovan,Thomas J. Montine,M. A. Nalls,Simon Mead,Eric M. Reiman,Palmi V. Jonsson,Clive Holmes,PH St George-Hyslop,PH St George-Hyslop,Mercè Boada,Peter Passmore,Jens R. Wendland,Reinhold Schmidt,Kevin Morgan,Ashley R. Winslow,John Powell,M. Carasquillo,Steven G. Younkin,Johanna Jakobsdottir,John K Kauwe,Kirk C. Wilhelmsen,Dan Rujescu,Markus M. Nöthen,Albert Hofman,Lesley Jones,Perrie M. Adams,Marilyn S. Albert,Marilyn S. Albert,Roger L Albin,Liana G. Apostolova,Steven E. Arnold,Sanjay Asthana,Craig S. Atwood,Clinton T Baldwin,Michjael M. Barmada,Lisa L. Barnes,Thomas G. Beach,James T. Becker,James T. Becker,Eileen H. Bigio,Thomas D Bird,Deborah Blacker,Bradley F. Boeve,James Bowen,A. Boxer,James R. Burke,Nigel J. Cairns,Chuanhai Cao,Christopher S. Carlson,Cynthia M. Carlsson,Regina M. Carney,Minerva M. Carrasquillo,Steven L. Carroll,Helena C. Chui,David G. Clark,Jason J. Corneveaux,David H. Cribbs,Elizabeth Crocco,Carlos Cruchaga,Philip L. De Jager,Philip L. De Jager,Philip L. De Jager,Charles DeCarli,Steven T. DeKosky,F. Yesim Demirci,Malcolm B. Dick,Dennis W. Dickson,Rachelle S. Doody,Ranjan Duara,Nilufer Ertekin-Taner,Kelley Faber,Thomas Fairchild,Kenneth B. Fallon,Martin R. Farlow,Steven H. Ferris,Matthew P. Frosch,Douglas Galasko,Marla Gearing,Daniel H. Geschwind,Bernardino Ghetti,John R. Gilbert,Jonathan D. Glass,Neill R. Graff-Radford,Robert C. Green,John H. Growdon,Hakon Hakonarson,Ronald L. Hamilton,John Hardy,John Hardy,Lindy E. Harrell,Elizabeth Head,Lawrence S. Honig,Ryan M. Huebinger,Matthew J. Huentelman,Christine M. Hulette,Bradley T. Hyman,Gail P. Jarvik,Gregory A. Jicha,Lee-Way Jin,Anna Karydas,John S. K. Kauwe,Jeffrey Kaye,Ronald C. Kim,Edward H. Koo,Neil W. Kowall,Joel H. Kramer,Frank M. LaFerla,James J. Lah,James B. Leverenz,Allan I. Levey,Ge Li,Andrew P. Lieberman,Chiao-Feng Lin,Oscar L. Lopez,Constantine G. Lyketsos,Wendy J. Mack,Daniel C. Marson,Frank Martiniuk,Deborah C. Mash,Eliezer Masliah,Wayne C. McCormick,Susan M. McCurry,Andrew McDavid,Ann C. McKee,M.-Marsel Mesulam,Bruce L. Miller,Carol A. Miller,Joshua W. Miller,John C. Morris,Shubhabrata Mukherjee,Jill R. Murrell,Amanda J. Myers,Sid E. O'Bryant,John M Olichney,Vernon S. Pankratz,Joseph E. Parisi,Amanda Partch,Henry L. Paulson,William Perry,Elaine R. Peskind,Ronald C. Petersen,Aimee Pierce,Wayne W. Poon,Huntington Potter,Joseph F. Quinn,Ashok Raj,Murray A. Raskind,Barry Reisberg,Joan S. Reisch,Christiane Reitz,John M. Ringman,Erik D. Roberson,Ekaterina Rogaeva,Howard J. Rosen,Roger N. Rosenberg,Donald R. Royall,Mark A. Sager,Mary Sano,Andrew J. Saykin,Julie A. Schneider,Lon S. Schneider,William W. Seeley,Amanda G. Smith,Joshua A. Sonnen,Salvatore Spina,Robert S. Stern,Rudolph E. Tanzi,Tricia A. Thornton-Wells,John Q. Trojanowski,Juan C. Troncoso,Debby W. Tsuang,Vivianna M. Van Deerlin,Linda J. Van Eldik,Badri N. Vardarajan,Harry V. Vinters,Jean Paul Vonsattel,Sandra Weintraub,Kathleen A. Welsh-Bohmer,Jennifer Williamson,Sarah Wishnek,Randall L. Woltjer,Clinton B. Wright,Chuang-Kuo Wu,Chang En Yu,Lei Yu,Rhoda Au,Philip A. Wolf,Alexa S. Beiser,Claudia L. Satizabal,André G. Uitterlinden,Fernando Rivadeneira,Peter J. Koudstaal,William T. Longstreth,Lewis H. Kuller,Thomas Lumley,Kenneth Rice,Tamara B. Harris,Mike A. Nalls,Josef Marksteiner,Peter Dal-Bianco,Anna Maria Töglhofer,Paul Freudenberger,Gerhard Ransmayr,Thomas Benke,Anna Maria Toeglhofer,Eric Boerwinkle,Jan Bressler,Myriam Fornage,Francisco J. Morón,Isabel Hernández,Maitee Rosende Roca,Ana Mauleón,Montserrat Alegret,Reposo Ramírez-Lorca,Antonio González-Pérez,Annick Alpérovitch,Victoria Alvarez,Pascale Barberger-Gateau,Karolien Bettens,Paola Bossù,Alexis Brice,María J. Bullido,Paolo Caffara,Jordi Clarimón,Onofre Combarros,Eliecer Coto,Maria del Zampo,Marc Delepine,Maria Candida Deniz Naranjo,Jacques Epelbaum,Laura Fratiglioni,Daniela Galimberti,Caroline Graff,Mikko Hiltunen,Martin Ingelsson,Lina Keller,Lars Lannfelt,Alberto Lleó,Michelangelo Mancuso,Ignacio Mateo,Patrizia Mecocci,Benedetta Nacmias,Francesco Panza,Alberto Pilotto,Florentino Sanchez Garcia,Elio Scarpini,Davide Seripa,Kristel Sleegers,Hlikka Soininen,Sandro Sorbi,Gianfranco Spalletta,David Wallon,Charlene Thomas,Amy Gerrish,Jade Chapman,Alexandra Stretton,Angharad R. Morgan,Harriet Oldham,Michael John Owen,Patrick G. Kehoe,Christopher Medway,Kristelle Brown,Jenny Lord,James Turton,Nigel M. Hooper,Emma R.L.C. Vardy,Jason D. Warren,Jonathan M. Schott,James Uphill,Paul Hollingworth,DClin Psy,Natalie S. Ryan,Martin N. Rossor,John Collinge,Yoav Ben-Shlomo,Daniilidou Makrina,Olymbia Gkatzima,Michelle K. Lupton,Maria Koutroumani,Despoina Avramidou,Antonia Germanou,Frank Jessen,Steffi G. Riedel-Heller,Martin Dichgans,R. Heun,Heike Kölsch,Britta Schürmann,Christine Herold,André Lacour,Dmitriy Drichel,Per Hoffmann,Johannes Kornhuber,Wei Gu,T. Feulner,Manuel Mayhaus,Sabrina Pichler,Matthias Riemenschneider,Hendrik van den Bussche,Brian A. Lawlor,Aoibhinn Lynch,David M. A. Mann,A. David Smith,Donald Warden,Gordon K. Wilcock,Isabella Heuser,Jens Wiltfang,Lutz Frölich,Michael Hüll,Kevin H. Mayo,Gill Livingston,Nicholas Bass,Hugh Gurling,Andrew McQuillin,Rhian Gwilliam,Panagiotis Deloukas,Ammar Al-Chalabi,Christopher Shaw,Andrew B. Singleton,Rita Guerreiro,Giancarlo Russo,Karl-Heinz Jöckel,Susanne Moebus,Norman Klopp,H-Erich Wichmann,Li Ma,Gina Bisceglio,Elizabeth M. C. Fisher,Nick Warner,Stuart Pickering-Brown,David Craig,Janet A. Johnston,Bernadette McGuinness,Stephen Todd,David C. Rubinsztein,Simon Lovestone,Anthony Bayer,John Gallacher,Petroula Proitsi,Sara Ortega-Cubero,Jonathan L. Haines,Bruce M. Psaty,Bruce M. Psaty,C. Van Broeckhoven,Peter Holmans,L. J. Launer,Richard Mayeux,Mark Lathrop,Alison Goate,Valentina Escott-Price,Sudha Seshadri,Margaret A. Pericak-Vance,P. Amouyel,P. Amouyel,P. Amouyel,Julie Williams,C M van Duijn,Gerard D. Schellenberg,Lindsay A. Farrer +450 more
TL;DR: The authors' APOE-stratified GWAS is the first to show GWS association for AD with SNPs in the chromosome 17q21.31 region, and the finding in the stage 1 sample that AD risk is significantly influenced by the interaction of APOE with TMEM106B (P=1·6 × 10−7) is noteworthy, because TMEM 106B variants have previously been associated with risk of frontotemporal dementia.
Common genetic variants associated with cognitive performance identified using the proxy-phenotype method
Cornelius A. Rietveld,Tõnu Esko,Gail Davies,Tune H. Pers,Patrick Turley,Beben Benyamin,Christopher F. Chabris,Valur Emilsson,Andrew D. Johnson,James J. Lee,C. deLeeuw,Riccardo E. Marioni,Sarah E. Medland,Michael B. Miller,Olga Rostapshova,S.J. van deLee,Anna A. E. Vinkhuyzen,Najaf Amin,Dalton Conley,Jaime Derringer,C.M. vanDuijn,Rudolf S N Fehrmann,Lude Franke,E.L. Glaeser,Narelle K. Hansell,Caroline Hayward,William G. Iacono,Carla A. Ibrahim-Verbaas,Vincent W. V. Jaddoe,Juha Karjalainen,David Laibson,Paul Lichtenstein,D C Liewald,Patrik K. E. Magnusson,Nicholas G. Martin,Matt McGue,Gearoid M. McMahon,Nancy L. Pedersen,Steven Pinker,David J. Porteous,Danielle Posthuma,F. Rivadeneira Ramirez,B.H. Smithk,John M. Starr,Henning Tiemeier,N.J. Timpsonm,M. Trzaskowskin,A.G. Uitterlinden,Frank C. Verhulst,Mary E. Ward,Margaret J. Wright,Albert V. Smith,Ian J. Deary,Magnus Johannesson,Robert Plomin,Peter M. Visscher,Daniel J. Benjamin,David Cesarini,Koellinger +58 more
TL;DR: This work identifies several common genetic variants associated with cognitive performance using a two-stage approach: a genome-wide association study of educational attainment to generate a set of candidates, and then the association of these variants with Cognitive performance is estimated.
Journal ArticleDOI
Common genetic variants associated with cognitive performance identified using the proxy-phenotype method
Cornelius A. Rietveld,Tõnu Esko,Gail Davies,Tune H. Pers,Patrick Turley,Beben Benyamin,Christopher F. Chabris,Valur Emilsson,Andrew D. Johnson,James J. Lee,Christiaan de Leeuw,Riccardo E. Marioni,Sarah E. Medland,Michael B. Miller,Olga Rostapshova,Sven J. van der Lee,Anna A. E. Vinkhuyzen,Najaf Amin,Dalton Conley,Jaime Derringer,Cornelia M. van Duijn,Rudolf S N Fehrmann,Lude Franke,Edward L. Glaeser,Narelle K. Hansell,Caroline Hayward,William G. Iacono,Carla A. Ibrahim-Verbaas,Vincent W. V. Jaddoe,Juha Karjalainen,David Laibson,Paul Lichtenstein,David C. Liewald,Patrik K. E. Magnusson,Nicholas G. Martin,Matt McGue,George McMahon,Nancy L. Pedersen,Steven Pinker,David J. Porteous,Danielle Posthuma,Fernando Rivadeneira,Blair H. Smith,John M. Starr,Henning Tiemeier,Nicholas J. Timpson,Maciej Trzaskowski,André G. Uitterlinden,Frank C. Verhulst,Mary E. Ward,Margaret J. Wright,George Davey Smith,Ian J. Deary,Magnus Johannesson,Robert Plomin,Peter M. Visscher,Daniel J. Benjamin,David Cesarini,Philipp Koellinger +58 more
TL;DR: This article identified common genetic variants associated with cognitive performance using a two-stage approach, which they call the proxy-phenotype method, and measured the association of these education-associated SNPs with the cognitive performance.
Journal ArticleDOI
Convergent genetic and expression data implicate immunity in Alzheimer's disease
Lesley Jones,Jean-Charles Lambert,Jean-Charles Lambert,Jean-Charles Lambert,Li-San Wang,Seung Hoan Choi,Denise Harold,Alexey Vedernikov,Valentina Escott-Price,Timothy Stone,Alexander Richards,Céline Bellenguez,Céline Bellenguez,Céline Bellenguez,Carla A. Ibrahim-Verbaas,Adam C. Naj,Rebecca Sims,Amy Gerrish,Gyungah Jun,Anita L. DeStefano,Joshua C. Bis,Gary W. Beecham,Gary W. Beecham,Benjamin Grenier-Boley,Benjamin Grenier-Boley,Benjamin Grenier-Boley,Giancarlo Russo,Tricia A. Thornton-Wells,Nicola Jones,Albert V. Smith,Vincent Chouraki,Vincent Chouraki,Vincent Chouraki,Charlene Thomas,M. Arfan Ikram,Diana Zelenika,Badri N. Vardarajan,Yoichiro Kamatani,Chiao-Feng Lin,Helena Schmidt,Brian W. Kunkle,Melanie L. Dunstan,Agustín Ruiz,Marie-Thérèse Bihoreau,Christiane Reitz,Florence Pasquier,Paul Hollingworth,Olivier Hanon,Annette L. Fitzpatrick,Joseph D. Buxbaum,Dominique Campion,Paul K. Crane,Tim Becker,Vilmundur Gudnason,Carlos Cruchaga,David Craig,Najaf Amin,Claudine Berr,Oscar L. Lopez,Philip L. De Jager,Philip L. De Jager,Vincent Deramecourt,Janet A. Johnston,Denis A. Evans,Simon Lovestone,Luc Letteneur,J. Kornhuber,Lluís Tárraga,David C. Rubinsztein,Gudny Eiriksdottir,Kristel Sleegers,Alison Goate,Nathalie Fievet,Nathalie Fievet,Matthew J. Huentelman,Michael Gill,Valur Emilsson,Kristelle Brown,M. Ilyas Kamboh,Lina Keller,Pascale Barberger-Gateau,Bernadette McGuinness,Eric B. Larson,Eric B. Larson,Amanda J. Myers,Carole Dufouil,Stephen Todd,David Wallon,Seth Love,Patrick G. Kehoe,Ekaterina Rogaeva,John Gallacher,Peter St George-Hyslop,Peter St George-Hyslop,Jordi Clarimón,Alberti Lleò,Anthony Bayer,Debby W. Tsuang,Lei Yu,Magda Tsolaki,Paola Bossù,Gianfranco Spalletta,Petra Proitsi,John Collinge,Sandro Sorbi,Florentino Sanchez Garcia,Nick C. Fox,John Hardy,Maria Candida Deniz Naranjo,Cristina Razquin,P. Bosco,Robert Clarke,Carol Brayne,Daniela Galimberti,Michelangelo Mancuso,Susanne Moebus,Patrizia Mecocci,Maria Del Zompo,Wolfgang Maier,Harald Hampel,Alberto Pilotto,María J. Bullido,Francesco Panza,Paolo Caffarra,Paolo Caffarra,Benedetta Nacmias,John R. Gilbert,John R. Gilbert,Manuel Mayhaus,Frank Jessen,Martin Dichgans,Lars Lannfelt,Hakon Hakonarson,Sabrina Pichler,Minerva M. Carrasquillo,Martin Ingelsson,Duane Beekly,Victoria Alavarez,Fanggeng Zou,Otto Valladares,Steven G. Younkin,Eliecer Coto,Kara L. Hamilton-Nelson,Ignacio Mateo,Michael John Owen,Kelley Faber,Palmi V. Jonsson,Onofre Combarros,Michael Conlon O'Donovan,Laura B. Cantwell,Hilkka Soininen,Deborah Blacker,Simon Mead,Thomas H. Mosley,David A. Bennett,Tamara B. Harris,Laura Fratiglioni,Laura Fratiglioni,Clive Holmes,Renée F.A.G. de Bruijn,Peter Passmore,Thomas J. Montine,Karolien Bettens,Jerome I. Rotter,Alexis Brice,Kevin Morgan,Tatiana Foroud,Walter A. Kukull,Didier Hannequin,John Powell,Mike A. Nalls,Karen Ritchie,Kathryn L. Lunetta,John S. K. Kauwe,Eric Boerwinkle,Eric Boerwinkle,Matthias Riemenschneider,Mercè Boada,Mikko Hiltunen,Eden R. Martin,Eden R. Martin,Pau Pastor,Pau Pastor,Reinhold Schmidt,Dan Rujescu,Jean-François Dartigues,Richard Mayeux,Christophe Tzourio,Albert Hofman,Markus M. Nöthen,Caroline Graff,Caroline Graff,Bruce M. Psaty,Jonathan L. Haines,Mark Lathrop,Mark Lathrop,Mark Lathrop,Margaret A. Pericak-Vance,Margaret A. Pericak-Vance,Lenore J. Launer,Lindsay A. Farrer,Cornelia M. van Duijn,Christine Van Broeckhoven,Alfredo Ramirez,Gerard D. Schellenberg,Sudha Seshadri,Philippe Amouyel,Julie Williams,Peter Holmans +208 more
TL;DR: Late‐onset Alzheimer's disease (AD) is heritable with 20 genes showing genome‐wide association in the International Genomics of Alzheimer's Project (IGAP), and this work extended these genetic data in a pathway analysis.
Journal ArticleDOI
GWAS for executive function and processing speed suggests involvement of the CADM2 gene
Carla A. Ibrahim-Verbaas,Jan Bressler,Stéphanie Debette,Maaike Schuur,Albert V. Smith,J. C. Bis,Gary Davies,Stella Trompet,Jennifer A. Smith,Christiane Wolf,Lori B. Chibnik,Yongmei Liu,Veronique Vitart,Mirna Kirin,Katja Petrovic,Ozren Polasek,Lina Zgaga,Chloe Fawns-Ritchie,Peter Hoffmann,Peter Hoffmann,Juha Karjalainen,Jari Lahti,David J. Llewellyn,Carsten Oliver Schmidt,Karen A. Mather,Vincent Chouraki,Qi Sun,Susan M. Resnick,Lynda M. Rose,Christopher Oldmeadow,Marlene C. W. Stewart,Blair H. Smith,Vilmundur Gudnason,Qiong Yang,Saira Saeed Mirza,Johan Wouter Jukema,P. L. DeJager,T.B. Harris,D C Liewald,Najaf Amin,Laura H. Coker,Oliver Stegle,Oscar L. Lopez,Reinhold Schmidt,Alexander Teumer,Ian Ford,Nazanin Karbalai,James T. Becker,Maria K. Jonsdottir,Rhoda Au,Rudolf S N Fehrmann,Stefan Herms,Stefan Herms,Mike A. Nalls,Wei Zhao,Stephen T. Turner,Kristine Yaffe,Kurt Lohman,J. C. van Swieten,Sharon L.R. Kardia,D. S. Knopman,William M. Meeks,Gerardo Heiss,Elizabeth G. Holliday,Peter W. Schofield,Toshiko Tanaka,David J. Stott,Jing Wang,Paul M. Ridker,Alan J. Gow,Alison Pattie,John M. Starr,Lynne J. Hocking,Nicola J. Armstrong,Stela McLachlan,Joshua M. Shulman,Luke C. Pilling,G. Eiriksdottir,Rodney J. Scott,Nicole A. Kochan,Aarno Palotie,Y. C. Hsieh,Johan G. Eriksson,Alan D. Penman,Rebecca F. Gottesman,Ben A. Oostra,Le Yu,Anita L. DeStefano,Alexa S. Beiser,Melissa Garcia,Jerome I. Rotter,Jerome I. Rotter,Markus M. Nöthen,Albert Hofman,P.E. Slagboom,R.G.J. Westendorp,Brendan M. Buckley,Philip A. Wolf,André G. Uitterlinden,Bruce M. Psaty,Hans-Jörgen Grabe,Stefania Bandinelli,Daniel I. Chasman,Francine Grodstein,Katri Räikkönen,Jean-Charles Lambert,David J. Porteous,Jenna Price,Perminder S. Sachdev,Luigi Ferrucci,John Attia,Igor Rudan,Caroline Hayward,Alan F. Wright,James F. Wilson,Sven Cichon,Lude Franke,Helena Schmidt,Jun Ding,A.J.M. de Craen,Myriam Fornage,David A. Bennett,Ian J. Deary,M. A. Ikram,L. J. Launer,Annette L. Fitzpatrick,Sudha Seshadri,C M van Duijn,Thomas H. Mosley +128 more
TL;DR: This article conducted a GWAS of executive functioning and information processing speed in non-demented older adults from the CHARGE (Cohorts for Heart and Aging Research in Genomic Epidemiology) consortium.