J
Jonathan Beesley
Researcher at QIMR Berghofer Medical Research Institute
Publications - 163
Citations - 16239
Jonathan Beesley is an academic researcher from QIMR Berghofer Medical Research Institute. The author has contributed to research in topics: Breast cancer & Cancer. The author has an hindex of 56, co-authored 158 publications receiving 14106 citations. Previous affiliations of Jonathan Beesley include Peter MacCallum Cancer Centre & Royal Brisbane and Women's Hospital.
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Journal ArticleDOI
Genome-wide association study identifies novel breast cancer susceptibility loci
Douglas F. Easton,Karen A. Pooley,Alison M. Dunning,Paul D.P. Pharoah,Deborah J. Thompson,Dennis G. Ballinger,Jeffery P. Struewing,Jonathan J. Morrison,Helen I. Field,Robert Luben,Nicholas J. Wareham,Shahana Ahmed,Catherine S. Healey,Richard Bowman,Kerstin B. Meyer,Christopher A. Haiman,Laurence K. Kolonel,Brian E. Henderson,Loic Le Marchand,Paul Brennan,Suleeporn Sangrajrang,Valerie Gaborieau,Fabrice Odefrey,Chen-Yang Shen,Pei-Ei Wu,Hui-Chun Wang,Diana Eccles,D. Gareth Evans,Julian Peto,Olivia Fletcher,Nichola Johnson,Sheila Seal,Michael R. Stratton,Nazneen Rahman,Georgia Chenevix-Trench,Georgia Chenevix-Trench,Stig E. Bojesen,Børge G. Nordestgaard,C K Axelsson,Montserrat Garcia-Closas,Louise A. Brinton,Stephen J. Chanock,Jolanta Lissowska,Beata Peplonska,Heli Nevanlinna,Rainer Fagerholm,H Eerola,Daehee Kang,Keun-Young Yoo,Dong-Young Noh,Sei Hyun Ahn,David J. Hunter,Susan E. Hankinson,David G. Cox,Per Hall,Sara Wedrén,Jianjun Liu,Yen-Ling Low,Natalia Bogdanova,Peter Schu¨rmann,Do¨rk Do¨rk,Rob A. E. M. Tollenaar,Catharina E. Jacobi,Peter Devilee,Jan G. M. Klijn,Alice J. Sigurdson,Michele M. Doody,Bruce H. Alexander,Jinghui Zhang,Angela Cox,Ian W. Brock,Gordon MacPherson,Malcolm W.R. Reed,Fergus J. Couch,Ellen L. Goode,Janet E. Olson,Hanne Meijers-Heijboer,Hanne Meijers-Heijboer,Ans M.W. van den Ouweland,André G. Uitterlinden,Fernando Rivadeneira,Roger L. Milne,Gloria Ribas,Anna González-Neira,Javier Benitez,John L. Hopper,Margaret R. E. McCredie,Margaret R. E. McCredie,Margaret R. E. McCredie,Melissa C. Southey,Melissa C. Southey,Graham G. Giles,Chris Schroen,Christina Justenhoven,Christina Justenhoven,Hiltrud Brauch,Hiltrud Brauch,Ute Hamann,Yon-Dschun Ko,Amanda B. Spurdle,Jonathan Beesley,Xiaoqing Chen,_ kConFab,Arto Mannermaa,Veli-Matti Kosma,Vesa Kataja,Jaana M. Hartikainen,Nicholas E. Day,David Cox,Bruce A.J. Ponder +109 more
TL;DR: To identify further susceptibility alleles, a two-stage genome-wide association study in 4,398 breast cancer cases and 4,316 controls was conducted, followed by a third stage in which 30 single nucleotide polymorphisms were tested for confirmation.
Journal ArticleDOI
Association analysis identifies 65 new breast cancer risk loci
Kyriaki Michailidou,Kyriaki Michailidou,Sara Lindström,Sara Lindström,Joe Dennis,Jonathan Beesley,Shirley Hui,Siddhartha Kar,Audrey Lemaçon,Penny Soucy,Dylan M. Glubb,Asha Rostamianfar,Manjeet K. Bolla,Qin Wang,Jonathan Tyrer,Ed Dicks,Andy C. H. Lee,Zhaoming Wang,Jamie Allen,Renske Keeman,Ursula Eilber,Juliet D. French,Xiaoqing Chen,Laura Fachal,Karen McCue,Amy E. McCart Reed,Maya Ghoussaini,Jason S. Carroll,Xia Jiang,Hilary K. Finucane,Hilary K. Finucane,Marcia Adams,Muriel A. Adank,Habibul Ahsan,Kristiina Aittomäki,Hoda Anton-Culver,Natalia Antonenkova,Volker Arndt,Kristan J. Aronson,Banu Arun,Paul L. Auer,Paul L. Auer,Francois Bacot,Myrto Barrdahl,Caroline Baynes,Matthias W. Beckmann,Sabine Behrens,Javier Benitez,Marina Bermisheva,Leslie Bernstein,Carl Blomqvist,Natalia Bogdanova,Stig E. Bojesen,Stig E. Bojesen,Bernardo Bonanni,Anne Lise Børresen-Dale,Judith S. Brand,Hiltrud Brauch,Hiltrud Brauch,Hiltrud Brauch,Paul Brennan,Hermann Brenner,Louise A. Brinton,Per Broberg,Ian W. Brock,Annegien Broeks,Angela Brooks-Wilson,Angela Brooks-Wilson,Sara Y. Brucker,Thomas Brüning,Barbara Burwinkel,Barbara Burwinkel,Katja Butterbach,Qiuyin Cai,Hui Cai,Trinidad Caldés,Federico Canzian,Angel Carracedo,Brian D. Carter,Jose E. Castelao,Tsun Leung Chan,Tongguang Cheng,Kee Seng Chia,Ji Yeob Choi,Hans Christiansen,Christine L. Clarke,Margriet Collée,Don M. Conroy,Emilie Cordina-Duverger,Sten Cornelissen,David G. Cox,David G. Cox,Angela Cox,Simon S. Cross,Julie M. Cunningham,Kamila Czene,Mary B. Daly,Peter Devilee,Kimberly F. Doheny,Thilo Dörk,Isabel dos-Santos-Silva,Martine Dumont,Lorraine Durcan,Miriam Dwek,Diana Eccles,Arif B. Ekici,A. Heather Eliassen,A. Heather Eliassen,Carolina Ellberg,Mingajeva Elvira,Christoph Engel,Mikael Eriksson,Peter A. Fasching,Peter A. Fasching,Jonine D. Figueroa,Dieter Flesch-Janys,Olivia Fletcher,Henrik Flyger,Lin Fritschi,Valerie Gaborieau,Marike Gabrielson,Manuela Gago-Dominguez,Yu Tang Gao,Susan M. Gapstur,José A. García-Sáenz,Mia M. Gaudet,Vassilios Georgoulias,Graham G. Giles,Graham G. Giles,Gord Glendon,Mark S. Goldberg,David E. Goldgar,Anna González-Neira,Grethe I. Grenaker Alnæs,Mervi Grip,Jacek Gronwald,Anne Grundy,Pascal Guénel,Lothar Haeberle,Eric Hahnen,Christopher A. Haiman,Niclas Håkansson,Ute Hamann,N Hamel,Susan E. Hankinson,Patricia Harrington,Steven N. Hart,Jaana M. Hartikainen,Mikael Hartman,Mikael Hartman,Alexander Hein,Jane Heyworth,Belynda Hicks,Peter Hillemanns,Dona N. Ho,Antoinette Hollestelle,Maartje J. Hooning,Robert N. Hoover,John L. Hopper,Ming-Feng Hou,Chia-Ni Hsiung,Guanmengqian Huang,Keith Humphreys,Junko Ishiguro,Hidemi Ito,Motoki Iwasaki,Hiroji Iwata,Anna Jakubowska,Wolfgang Janni,Esther M. John,Esther M. John,Nichola Johnson,Kristine Jones,Michael Jones,Arja Jukkola-Vuorinen,Rudolf Kaaks,Maria Kabisch,Katarzyna Kaczmarek,Daehee Kang,Daehee Kang,Yoshio Kasuga,Michael J. Kerin,Sofia Khan,Elza Khusnutdinova,Elza Khusnutdinova,Johanna I. Kiiski,Sung-Won Kim,Julia A. Knight,Julia A. Knight,Veli-Matti Kosma,Vessela N. Kristensen,Vessela N. Kristensen,Ute Krüger,Ava Kwong,Diether Lambrechts,Loic Le Marchand,Eunjung Lee,Min Hyuk Lee,Jong Won Lee,Chuen Neng Lee,Flavio Lejbkowicz,Jingmei Li,Jenna Lilyquist,Annika Lindblom,Jolanta Lissowska,Wing-Yee Lo,Wing-Yee Lo,Sibylle Loibl,Jirong Long,Artitaya Lophatananon,Artitaya Lophatananon,Jan Lubinski,Craig Luccarini,Michael P. Lux,Edmond S. K. Ma,Robert J. MacInnis,Robert J. MacInnis,Tom Maishman,Enes Makalic,Kathleen E. Malone,Ivana Maleva Kostovska,Arto Mannermaa,Siranoush Manoukian,JoAnn E. Manson,JoAnn E. Manson,Sara Margolin,Shivaani Mariapun,Maria Elena Martinez,Keitaro Matsuo,Dimitrios Mavroudis,James McKay,Catriona McLean,Hanne Meijers-Heijboer,Alfons Meindl,Primitiva Menéndez,Usha Menon,J.-P. Meyer,Hui Miao,Nicola Miller,Nur Aishah Taib,Kenneth Muir,Kenneth Muir,Anna Marie Mulligan,Anna Marie Mulligan,Claire Mulot,Susan L. Neuhausen,Heli Nevanlinna,Patrick Neven,Sune F. Nielsen,Dong-Young Noh,Børge G. Nordestgaard,Børge G. Nordestgaard,Aaron D. Norman,Olufunmilayo I. Olopade,Janet E. Olson,Håkan Olsson,Curtis Olswold,Nick Orr,V. Shane Pankratz,Sue K. Park,Sue K. Park,Tjoung-Won Park-Simon,Rachel Lloyd,Jose Ignacio Arias Perez,Paolo Peterlongo,Julian Peto,Kelly-Anne Phillips,Mila Pinchev,Dijana Plaseska-Karanfilska,Ross L. Prentice,Nadege Presneau,Darya Prokofyeva,Elizabeth W. Pugh,Katri Pylkäs,Brigitte Rack,Paolo Radice,Nazneen Rahman,Gadi Rennert,Hedy S. Rennert,Valerie Rhenius,Atocha Romero,Jane Romm,Kathryn J. Ruddy,Thomas Rüdiger,Anja Rudolph,Matthias Ruebner,Emiel J. Th. Rutgers,Emmanouil Saloustros,Dale P. Sandler,Suleeporn Sangrajrang,Elinor J. Sawyer,Daniel F. Schmidt,Rita K. Schmutzler,Andreas Schneeweiss,Minouk J. Schoemaker,Fredrick R. Schumacher,Peter Schürmann,Rodney J. Scott,Rodney J. Scott,Christopher G. Scott,Sheila Seal,Caroline Seynaeve,Mitul Shah,Priyanka Sharma,Chen-Yang Shen,Chen-Yang Shen,Grace Sheng,Mark E. Sherman,Martha J. Shrubsole,Xiao-Ou Shu,Ann Smeets,Christof Sohn,Melissa C. Southey,John J. Spinelli,John J. Spinelli,Christa Stegmaier,Sarah Stewart-Brown,Jennifer Stone,Jennifer Stone,Daniel O. Stram,Harald Surowy,Harald Surowy,Anthony J. Swerdlow,Rulla M. Tamimi,Rulla M. Tamimi,Jack A. Taylor,Maria Tengström,Soo Hwang Teo,Mary Beth Terry,Daniel C. Tessier,Somchai Thanasitthichai,Kathrin Thöne,Rob A. E. M. Tollenaar,Ian Tomlinson,Ling Tong,Diana Torres,Diana Torres,Thérèse Truong,Chiu-Chen Tseng,Shoichiro Tsugane,Hans-Ulrich Ulmer,Giske Ursin,Michael Untch,Celine M. Vachon,Christi J. van Asperen,David Van Den Berg,Ans M.W. van den Ouweland,Lizet E. van der Kolk,Rob B. van der Luijt,Daniel Vincent,Jason Vollenweider,Quinten Waisfisz,Shan Wang-Gohrke,Clarice R. Weinberg,Camilla Wendt,Alice S. Whittemore,Hans Wildiers,Walter C. Willett,Robert Winqvist,Alicja Wolk,Anna H. Wu,Lucy Xia,Taiki Yamaji,Xiaohong R. Yang,Cheng Har Yip,Keun-Young Yoo,Jyh-Cherng Yu,Wei Zheng,Ying Zheng,Bin Zhu,Argyrios Ziogas,Elad Ziv,Sunil R. Lakhani,Sunil R. Lakhani,Antonis C. Antoniou,Arnaud Droit,Irene L. Andrulis,Irene L. Andrulis,Christopher I. Amos,Fergus J. Couch,Paul D.P. Pharoah,Jenny Chang-Claude,Jenny Chang-Claude,Per Hall,David J. Hunter,Roger L. Milne,Roger L. Milne,Montserrat Garcia-Closas,Marjanka K. Schmidt,Stephen J. Chanock,Alison M. Dunning,Stacey L. Edwards,Gary D. Bader,Georgia Chenevix-Trench,Jacques Simard,Peter Kraft,Douglas F. Easton +396 more
TL;DR: A genome-wide association study of breast cancer in 122,977 cases and 105,974 controls of European ancestry and 14,068 cases and 13,104 controls of East Asian ancestry finds that heritability of Breast cancer due to all single-nucleotide polymorphisms in regulatory features was 2–5-fold enriched relative to the genome- wide average.
Journal ArticleDOI
Beyond GWASs: illuminating the dark road from association to function.
TL;DR: Recent approaches to the functional follow-up of GWAS loci, including fine mapping ofGWAS signal(s), prioritization of putative functional SNPs by the integration of genetic epidemiological and bioinformatic methods, and in vitro and in-vivo experimental verification of predicted molecular mechanisms for identifying the targeted genes are reviewed.
Journal ArticleDOI
A common coding variant in CASP8 is associated with breast cancer risk
Angela Cox,Alison M. Dunning,Montserrat Garcia-Closas,Sabapathy P. Balasubramanian,Malcolm W.R. Reed,Karen A. Pooley,Serena Scollen,Caroline Baynes,Bruce A.J. Ponder,Stephen J. Chanock,Jolanta Lissowska,Louise A. Brinton,Beata Peplonska,Melissa C. Southey,John L. Hopper,Margaret R. E. McCredie,Graham G. Giles,Olivia Fletcher,Nichola Johnson,Isabel dos Santos Silva,Lorna Gibson,Stig E. Bojesen,Børge G. Nordestgaard,C K Axelsson,Diana Torres,Ute Hamann,Christina Justenhoven,Christina Justenhoven,Hiltrud Brauch,Hiltrud Brauch,Jenny Chang-Claude,Silke Kropp,Angela Risch,Shan Wang-Gohrke,Peter Schürmann,Natalia Bogdanova,Thilo Dörk,Rainer Fagerholm,Kirsimari Aaltonen,Carl Blomqvist,Heli Nevanlinna,Sheila Seal,Anthony Renwick,Michael R. Stratton,Nazneen Rahman,Suleeporn Sangrajrang,David J. Hughes,Fabrice Odefrey,Paul Brennan,Amanda B. Spurdle,Georgia Chenevix-Trench,Jonathan Beesley,Arto Mannermaa,Jaana M. Hartikainen,Vesa Kataja,Veli-Matti Kosma,Fergus J. Couch,Janet E. Olson,Ellen L. Goode,Annegien Broeks,Marjanka K. Schmidt,Frans B. L. Hogervorst,Laura J. van't Veer,Daehee Kang,Keun-Young Yoo,Dong Young Noh,Sei Hyun Ahn,Sara Wedrén,Per Hall,Yen-Ling Low,Jianjun Liu,Roger L. Milne,Gloria Ribas,Anna González-Neira,Javier Benitez,Alice J. Sigurdson,Alice J. Sigurdson,Denise L. Stredrick,Denise L. Stredrick,Bruce H. Alexander,Bruce H. Alexander,Jeffery P. Struewing,Jeffery P. Struewing,Paul D.P. Pharoah,Douglas F. Easton +84 more
TL;DR: It is demonstrated that common breast cancer susceptibility alleles with small effects on risk can be identified, given sufficiently powerful studies, as well as the need for further studies to confirm putative genetic associations with breast cancer.
Journal ArticleDOI
Genome-wide association analysis of more than 120,000 individuals identifies 15 new susceptibility loci for breast cancer
Kyriaki Michailidou,Jonathan Beesley,Sara Lindström,Sander Canisius,Joe Dennis,Michael Lush,Mel Maranian,Manjeet K. Bolla,Qin Wang,Mitul Shah,Barbara Perkins,Kamila Czene,Mikael Eriksson,Hatef Darabi,Judith S. Brand,Stig E. Bojesen,Børge G. Nordestgaard,Henrik Flyger,Henrik Flyger,Sune F. Nielsen,Nazneen Rahman,Clare Turnbull,Olivia Fletcher,Julian Peto,Lorna Gibson,Isabel dos-Santos-Silva,Jenny Chang-Claude,Dieter Flesch-Janys,Anja Rudolph,Ursula Eilber,Sabine Behrens,Heli Nevanlinna,Taru A. Muranen,Taru A. Muranen,Kristiina Aittomäki,Kristiina Aittomäki,Carl Blomqvist,Carl Blomqvist,Sofia Khan,Sofia Khan,Kirsimari Aaltonen,Kirsimari Aaltonen,Habibul Ahsan,Muhammad G. Kibriya,Alice S. Whittemore,Esther M. John,Kathleen E. Malone,Marilie D. Gammon,Marilie D. Gammon,Regina M. Santella,Giske Ursin,Giske Ursin,Enes Makalic,Daniel F. Schmidt,Graham Casey,David J. Hunter,Susan M. Gapstur,Mia M. Gaudet,W. Ryan Diver,Christopher A. Haiman,Fredrick R. Schumacher,Brian E. Henderson,Loic Le Marchand,Christine D. Berg,Stephen J. Chanock,Jonine D. Figueroa,Robert N. Hoover,Diether Lambrechts,Patrick Neven,Patrick Neven,Hans Wildiers,Erik Van Limbergen,Marjanka K. Schmidt,Annegien Broeks,Senno Verhoef,Sten Cornelissen,Fergus J. Couch,Janet E. Olson,Emily Hallberg,Emily Hallberg,Emily Hallberg,Celine M. Vachon,Quinten Waisfisz,Quinten Waisfisz,Hanne Meijers-Heijboer,Muriel A. Adank,Rob B. van der Luijt,Jingmei Li,Jianjun Liu,Jianjun Liu,Keith Humphreys,Keith Humphreys,Daehee Kang,Ji Yeob Choi,Sue K. Park,Keun-Young Yoo,Keun-Young Yoo,Keitaro Matsuo,Hidemi Ito,Hiroji Iwata,Kazuo Tajima,Pascal Guénel,Thérèse Truong,Claire Mulot,Marie Sanchez,Barbara Burwinkel,Frederik Marme,Harald Surowy,Christof Sohn,Anna H. Wu,Chiu-Chen Tseng,Chiu-Chen Tseng,David Van Den Berg,Daniel O. Stram,Anna González-Neira,Javier Benitez,M. Pilar Zamora,Jose Ignacio Arias Perez,Xiao-Ou Shu,Xiao-Ou Shu,Wei Lu,Wei Lu,Wei Lu,Yu Tang Gao,Yu Tang Gao,Yu Tang Gao,Hui Cai,Hui Cai,Angela Cox,Simon S. Cross,Malcolm W.R. Reed,Irene L. Andrulis,Julia A. Knight,Julia A. Knight,Gord Glendon,Gord Glendon,Anna Marie Mulligan,Elinor J. Sawyer,Ian Tomlinson,Michael J. Kerin,Nicola Miller,Annika Lindblom,Sara Margolin,Soo Hwang Teo,Cheng Har Yip,Nur Aishah Taib,Gie Hooi Tan,Maartje J. Hooning,Antoinette Hollestelle,John W. M. Martens,J. Margriet Collée,William Blot,Lisa B. Signorello,Qiuyin Cai,John L. Hopper,John L. Hopper,Melissa C. Southey,Helen Tsimiklis,Carmel Apicella,Chen-Yang Shen,Chia-Ni Hsiung,Pei Ei Wu,Pei Ei Wu,Ming-Feng Hou,Vessela N. Kristensen,Silje Nord,Grethe I. Grenaker Alnæs,Graham G. Giles,Roger L. Milne,Catriona McLean,Catriona McLean,Federico Canzian,Federico Canzian,Dimitrios Trichopoulos,Petra P.H. Peeters,Eiliv Lund,Malin Sund,Kay-Tee Khaw,Marc J. Gunter,Domenico Palli,Lotte Maxild Mortensen,Laure Dossus,José María Huerta,José María Huerta,A. Meindl,Rita K. Schmutzler,Christian Sutter,Rongxi Yang,Kenneth Muir,Artitaya Lophatananon,Sarah Stewart-Brown,Sarah Stewart-Brown,Sarah Stewart-Brown,Pornthep Siriwanarangsan,Pornthep Siriwanarangsan,Mikael Hartman,Hui Miao,Kee Seng Chia,Ching Wan Chan,Peter A. Fasching,Alexander Hein,Matthias W. Beckmann,Lothar Haeberle,Hermann Brenner,Aida Karina Dieffenbach,Volker Arndt,Christa Stegmaier,Alan Ashworth,Nick Orr,Minouk J. Schoemaker,Anthony J. Swerdlow,Louise A. Brinton,Montserrat Garcia-Closas,Wei Zheng,Sandra L. Halverson,Martha J. Shrubsole,Martha J. Shrubsole,Jirong Long,Jirong Long,Mark S. Goldberg,Martine Dumont,Robert Winqvist,Katri Pylkäs,Katri Pylkäs,Arja Jukkola-Vuorinen,Arja Jukkola-Vuorinen,Mervi Grip,Mervi Grip,Hiltrud Brauch,Ute Hamann,Thomas Brüning,Paolo Radice,Paolo Peterlongo,Siranoush Manoukian,Loris Bernard,Natalia Bogdanova,Natalia Bogdanova,Thilo Dörk,Thilo Dörk,Arto Mannermaa,Arto Mannermaa,Vesa Kataja,Vesa Kataja,Veli-Matti Kosma,Jaana M. Hartikainen,Peter Devilee,Robert A.E.M. Tollenaar,Caroline M. Seynaeve,Christi J Asperen,Anna Jakubowska,Jan Lubinski,Katarzyna Jaworska,Tomasz Huzarski,Suleeporn Sangrajrang,Suleeporn Sangrajrang,Valerie Gaborieau,Paul Brennan,James McKay,Susan L. Slager,Amanda E. Toland,Christine B. Ambrosone,Drakoulis Yannoukakos,Maria Kabisch,Diana Torres,Susan L. Neuhausen,Hoda Anton-Culver,Craig Luccarini,Caroline Baynes,S. Ahmed,Catherine S. Healey,Daniel C. Tessier,Daniel Vincent,Francois Bacot,G Pita,M. Rosario Alonso,Nuria Álvarez,Daniel Herrero,Jacques Simard,Paul D.P. Pharoah,Peter Kraft,Alison M. Dunning,Georgia Chenevix-Trench,Per Hall,Douglas F. Easton +283 more
TL;DR: 15 new loci associated with breast cancer at P < 5 × 10−8 are identified, and one association appears to be driven by an amino acid substitution encoded in EXO1, which is found in women of European ancestry.