Ladoke Akintola University of Technology

About: Ladoke Akintola University of Technology is a education organization based out in Ogbomoso, Nigeria. It is known for research contribution in the topics: Population & Adsorption. The organization has 2786 authors who have published 3066 publications receiving 36850 citations. The organization is also known as: Oyo State University of Technology & LAUTECH.

Prevalence of co-resistance to disinfectants and clinically relevant antibiotics in bacterial isolates from three hospital laboratory wastewaters in Southwestern Nigeria

Abstract: The prevalence of co-resistance to four disinfectants and seven antibiotics was investigated among 57 bacterial strains isolated from the effluents of three hospital laboratories in Ogbomoso, Southwestern Nigeria. The organisms belonging to seven genera of public health importance such as Pseudomonas, Streptococcus, Serratia, Staphylococcus, Klebsiella, Proteus and Bacillus showed varying degrees of resistance to the test antimicrobial agents ranging from 0% to 77.8%. From among 25 organisms isolated from hospital A were recognized 16 phenotypic patterns of co-resistance to the test disinfectants and antibiotics; while from hospitals B and C were recognized 13 and 9 patterns, respectively, from among 18 and 14 isolates. The observed co-resistance to antimicrobial agents among the organisms reported in the present study is an indication of the risks posed by the untreated effluents to public health. It also adds to the increasing evidence about the role of hospital wastewaters as environmental reservoir of multi-drug-resistant bacteria.

A Survey of prevalence of serum antibodies to human immunodeficiency deficiency virus (HIV), hepatitis B virus (HBV) and hepatitis C virus (HCV) among blood donors.

Abstract: Background: It is a well known fact that HIV, HBV and HCV are global infectious pathogens contributing to mortality and morbidity in all ages thereby making them infections of grievous public health importance . As donor's potend a possible risk of transfusing these infections of global importance, it makes it imperative for the screening of blood and blood products for these pathogens. Aim: This study aims at determining the seroprevalence of HIV, HBV and HCV among intending blood donors. Subjects and Methods: A retrospective data analysis for seroprevalence of antibodies to HIV, HBV and HCV was carried out between the 2 nd of January and 15 th of June 2010 among intending blood donors aged 18-45 and the association of these infections with age group and blood group were analyzed. Sterile venous anticoagulated blood was collected from each of the donors and analyzed for HIV, HBV and HCV using highly sensitive and specific kits. All the positive samples for HIV- 1/2 were sent for reconfirmation using polymerase chain reaction. Results: Of the 427 samples analyzed, 203 were positive for HIV, 200 for HBV and 24 for HCV, representing a prevalence of 47.54%, 46.83% and 5.71% respectively among intending blood donors. Among them, blood group O positive was the most common blood group with 59.25% followed by blood group B positive, A positive and O negative respectively (p<0.001). The analysis of relationship showed a tendency of high association of these infections in subjects with O positive blood group. Conclusion: This study emphasizes the need for proper screening of blood donors for HIV, HBV and HCV.

Exposure to petroleum hydrocarbon: implications in lung lipid peroxidation and antioxidant defense system in rat.

Abstract: Objective: Various studies have implicated automobile exhausts as risk factors in cardiovascular and pulmonary diseases; however, there is little or no documentation on the role of the main source of the exhausts, petroleum hydrocarbons, on cardiopulmonary pathologies. Thus, we investigated the effect of petroleum hydrocarbons, using various petroleum products, on histomorphology of the lung and the role of lipid peroxidation in it. Materials and Methods: Control rats were not exposed to any of the petroleum products, whereas petrol-exposed, diesel-exposed, and kerosene-exposed rats were exposed to petrol, diesel, and kerosene by inhalation, respectively. Results: Exposure to petroleum hydrocarbons significantly induced lipid peroxidation with a consequent rise in malondialdehyde (MDA), and a decrease in superoxide dismutase (SOD) and catalase (CAT) activities and glutathione (GSH) level. Exposure to petroleum hydrocarbons also caused an alteration in the histomorphology of lung tissues. Conclusion: Our findings imply that exposure to petroleum hydrocarbons by inhalation is a risk factor in the pathophysiology of pulmonary dysfunction. This is associated with oxidative stress.

Production of bioemulsifier by an unusual isolate of salmon/red melanin containing Rhodotorula glutinis

Abstract: An unusual isolate of Rhodotorula glutinis was obtained. The yeast produces a spore and a crystalliferous protein per cell. Sodium dodecyl sulfate polyacrylamide gel electrophoresis revealed that the parasporal crystals contained polypeptides with a molecular mass of approximately 55, 47, 40, 36 32.5, 30 and 25 kD. The yeast also produces a salmon/red pigment at late stage of exponential growth, which has physical and chemical properties that are consistent with it being a form of melanin. The organism has been used to produce bioemulsifier with emulsion index of 80% when tested against kerosene and crude oil. The bioemulsifier has been shown to be capable of eliminating about 76% of crude oil pollutant. The colonial and mycelia forms of Rhodosporidium toruloides and Rhodosporidium sphaerocarpum have been successfully isolated from the unusual organism. African Journal of Biotechnology Vol. 4 (2), pp. 164-171, 2005

Green Nanotechnology in Nigeria: The Research Landscape, Challenges and Prospects

Abstract: Abstract In this treatise, we examined the activities of researchers of Nigeria descent in the frontier areas of nanoscience and nanotechnology, with a focus on green nanotechnology. The exploration of literature published by scholars were reviewed and compartmentalized on the basis of applications of the nanomaterials. It can be concluded that the level of activities in this area is expanding owing to the emergence of more published works since the beginning of 2010. However, in comparison with research outputs from other developing African countries such as South Africa and Egypt, activities in green nanotechnology are still at low ebb in Nigeria. Issues that are contributory to the slow pace were identified and appropriate solutions in terms of improved funding of education, enactment of national policy on nanotechnology, curriculum development, international cooperation as well as human resource development among others were discussed.