Ladoke Akintola University of Technology

About: Ladoke Akintola University of Technology is a education organization based out in Ogbomoso, Nigeria. It is known for research contribution in the topics: Population & Adsorption. The organization has 2786 authors who have published 3066 publications receiving 36850 citations. The organization is also known as: Oyo State University of Technology & LAUTECH.

Lipid peroxidation inhibition and antiradical activities of some leaf fractions of Mangifera indica.

Abstract: This study was undertaken to assess in vitro lipid peroxidation inhibitions and anti-radical activities of methanolic, chloroform, ethyl acetate and water fractions of Mangifera indica leaf. Inhibition of Fe(2+)-induced lipid peroxidation (LPO) in egg, brain, and liver homogenates, 1,1-diphenyl-2-picrylhydrazyl (DPPH) and hydroxyl (OH-) radical scavenging activities were evaluated. Total phenol was assessed in all fractions, and the reducing power of methanolic fraction was compared to gallic acid and ascorbic acid. The results showed that Fe2+ induced significant lipid peroxidation (LPO) in all the homogenates. Ethyl acetate fraction showed the highest percentage inhibition of LPO in both egg yolk (68.3%) and brain (66.3%), while the aqueous fraction exerted the highest inhibition in liver homogenate (89.1%) at a concentration of 10 microg/mL. These observed inhibitions of LPO by these fractions were higher than that of ascorbic acid used as a standard. The DPPH radical scavenging ability exhibited by ethyl acetate fraction was found to be the highest with IC50 value of 1.5 microg/mL. The ethyl acetate and methanolic fractions had the highest OH- radical scavenging ability with the same IC50 value of 5 microg/mL. The total phenol content of ethyl acetate fraction was the highest with 0.127 microg/mg gallic acid equivalent (GAE). The reductive potential of methanolic fraction showed a concentration-dependent increase. This study showed that inhibition of LPO and the DPPH and OH- radicals scavenging abilities of Mangifera indica leaf could be related to the presence of phenolic compounds. Therefore, the ethyl acetate fraction of the leaf may be a good source of natural antioxidative agent.

Gene frequencies of abo and rhesus blood groups and haemoglobin variants in ogbomoso, South – West Nigeria

Abstract: The distribution and gene frequencies of ABO and Rhesus (Rh) blood groups and haemoglobin variants for samples of the Nigerian population at Ogbomoso, was determined. Data consisting of records of blood groups and haemoglobin types of different ages ranging from infants to adults for a period of 4 to 6 years (1995 – 2000) was collected from Baptist Medical Centre (BMC), Ladoke Akintola University of Technology Health Centre (LAUTHC) and Oyo State General Hospital (OSGH), all in Ogbomoso, Oyo State, Nigeria. Overall, a total number of 7653, 7053 and 14,845 individuals were typed for ABO and Rh blood groups; and haemoglobin genotypes, respectively. 3824 (50 %) were blood group O, 1750 (22.9 %) were blood group A, 1629 (21.3 %) were blood group B and 450 (5.9 %) were blood group AB. This distribution differs significantly (P 0.05). The gene frequencies of D and d alleles were 0.82 and 0.18, respectively. Six haemoglobin genotypes were recorded in the order of AA (68.1 %) > AS (21.0 %) > AC (5.7 %) >SS (3.0 %) >SC (2.0 %) >CC (0.3 %). The gene frequencies were 0.81, 0.14 and 0.04 for A, S and C alleles, respectively. Our results are representative of the distribution of these genetic variants in Nigeria. (Global Journal of Medical Science, 2004, 3 (1&2): 17-22)

The biology and potential biotechnological applications of Bacillus safensis

Abstract: Bacillus safensis colonizes a wide range of habitats, many of which are stringent for the survival of some microorganisms. Its survival in extreme environments relies on its unique physiological and genotypic characteristics. It was originally identified as a recalcitrant contaminant in a spacecraft-assembly facility (SAF) at the Jet Propulsion Laboratory, USA, from which it derived its specific epithet, safensis. The bacterium belongs to the Bacillus pumilus group, and is closely related to Bacillus pumilus, Bacillus altitudinis, Bacillus xiamenensis and Bacillus invictae. At times, B. safensis has been erroneously identified as B. pumilus, especially when extensive molecular analyses and some mass spectroscopic methods, such as matrix-assisted laser desorption/ionization time-of-fiight mass spectrometry (MALDI-TOF-MS), are not considered. B. safensis possesses some plant growth-promoting traits and also has promising biotechnological applications due to its ability to produce various industrial enzymes and industrially applicable secondary metabolites. It may be regarded as a safe industrial microorganism because its pathogenicity has never been evidenced. This review attempts to chronicles the biology of B. safensis and its exploit as a potential industrially important bacterium. The ecology, physiology, genetics, and biotechnological applications of B. safensis are hereby presented in this review. This represents the first compendium of information on its attributes and applications that may be useful in opening a new vista of research on the bacterium.

CuO nanoparticles (CuO NPs) for water treatment: A review of recent advances

Abstract: Copper oxide nanoparticles (CuO NPs) are regularly investigated and effective adsorbent materials due to their small size, high surface area, natural abundance of starting material for synthesis, low-cost production processing and non-toxic nature. In this study, the adsorption of pollutants by CuO NPs was reviewed. The goal was to synthesise recent research findings, identify knowledge gaps and predict areas for future work. Conventional chemical processes like microwave heating technique and precipitation are the most popularly employed techniques for the synthesis of CuO NPs. The highest reported adsorption capacity for CuO NPs was 3152 mg/g for fluoride showing it can remove more than 3 times its weight fluoride from the aqueous phase. The best-fit kinetics and isotherm models for adsorption using CuO NPs is the pseudo-second order model (R2 > 0.99) and Langmuir model (R2 > 0.99) respectively for dyes and heavy metals. Thermodynamics analysis revealed that the adsorption by CuO NPs process was majorly spontaneous and endothermic. CuO NPs can be reused for as much as 5 cycles with >80 % recovery of pollutants in most cases. Areas for future work include mechanistic investigations by statistical physics, competitive adsorption and column experiments. Due to the negative ecotoxicological effect of the use of CuO NPs, special care must be taken to remove/recover it from wastewater before environmental release. It is surmised that CuO NPs is an effectively used adsorbent for the mitigation of various pollutants from the aqueous environment.