Institution
Louisiana State University
Education•Baton Rouge, Louisiana, United States•
About: Louisiana State University is a education organization based out in Baton Rouge, Louisiana, United States. It is known for research contribution in the topics: Population & Poison control. The organization has 40206 authors who have published 76587 publications receiving 2566076 citations. The organization is also known as: LSU & Louisiana State University and Agricultural and Mechanical College.
Topics: Population, Poison control, Gene, Context (language use), Wetland
Papers published on a yearly basis
Papers
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TL;DR: In this setup, dependence of the signal on the phase evolves n times faster than in traditional schemes, and uncertainty in the phase estimation is better than 1/n, and the quantum Cramer-Rao bound is saturate.
Abstract: We study the sensitivity and resolution of phase measurement in a Mach-Zehnder interferometer with two-mode squeezed vacuum (n photons on average). We show that superresolution and sub-Heisenberg sensitivity is obtained with parity detection. In particular, in our setup, dependence of the signal on the phase evolves n times faster than in traditional schemes, and uncertainty in the phase estimation is better than 1/n, and we saturate the quantum Cramer-Rao bound.
356 citations
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TL;DR: The findings suggest that the increased albumin leakage observed in postcapillary venules after inhibition of nitric oxide production involves a mechanism that includes a role for cGMP, platelet activating factor, leukocyte-endothelial cell adhesion, and the endothelial cell cytoskeleton.
Abstract: The mechanisms by which nitric oxide modulates microvascular albumin exchange were investigated by monitoring leukocyte-endothelial cell adhesion and fluorescein isothiocyanate-albumin leakage in rat mesenteric venules exposed to NG-nitro-L-arginine methyl ester (L-NAME). L-NAME elicited an initial rapid increase followed by a slower rate of albumin accumulation in the interstitial space. The initial phase of albumin leakage preceded the L-NAME-induced leukocyte adherence and emigration, whereas the magnitude of the albumin leakage observed in the later phase of L-NAME exposure was highly correlated with the number of adherent and emigrated leukocytes in the same segment of venule. Monoclonal antibodies (MAbs) directed against adhesion molecules CD11/CD18, ICAM-1, or P-selectin, but not a nonbinding MAb, attenuated the albumin leakage induced by L-NAME. WEB2086, a platelet activating factor antagonist, and 8-bromoguanosine 3',5'-cyclic monophosphate (8-br-cGMP) reduced the leukocyte adherence and emigration as well as the increased albumin leakage. Only 8-br-cGMP and the P-selectin MAb attenuated the platelet-leukocyte aggregation elicited by L-NAME. Phalloidin, which promotes endothelial junctional integrity, inhibited both the early and late phases of albumin leakage. Overall, these findings suggest that the increased albumin leakage observed in postcapillary venules after inhibition of nitric oxide production involves a mechanism that includes a role for cGMP, platelet activating factor, leukocyte-endothelial cell adhesion, and the endothelial cell cytoskeleton.
356 citations
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TL;DR: It is suggested thatACE2 is localized to the cytoplasm of neuronal cells in the brain and that ACE2 levels appear highly regulated by other components of the renin-angiotensin system, confirming its involvement in this system.
Abstract: Angiotensin-converting enzyme 2 (ACE2) is a newly discovered carboxy-peptidase responsible for the formation of vasodilatory peptides such as angiotensin-(1–7). We hypothesized that ACE2 is part of...
355 citations
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TL;DR: In this article, it is argued that the question over whether top-level leadership significantly affects organizational performance can be clarified by properly interpreting the results of executive succession studies that have used economic aspects of organizational performance as criteria When several methodological concerns are addressed, it is evident that executive leadership can explain as much as 45% of an organization's performance.
355 citations
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University of Edinburgh1, Fred Hutchinson Cancer Research Center2, University of Southampton3, Katholieke Universiteit Leuven4, University of Oxford5, Broad Institute6, United States Department of the Army7, Technical University of Denmark8, University of Cambridge9, Wellcome Trust Sanger Institute10, Erasmus University Rotterdam11, Bernhard Nocht Institute for Tropical Medicine12, Public Health England13, Pasteur Institute14, University of Sierra Leone15, Harvard University16, University of Liverpool17, University of Makeni18, University of Bristol19, University of Birmingham20, Princeton University21, Centre national de la recherche scientifique22, Louisiana State University23, Scripps Research Institute24, Scripps Health25, World Health Organization26, Chinese Center for Disease Control and Prevention27, University of Sydney28, Imperial College London29, National Institutes of Health30, Centers for Disease Control and Prevention31, University of California, Los Angeles32
TL;DR: It is revealed that this large epidemic was a heterogeneous and spatially dissociated collection of transmission clusters of varying size, duration and connectivity, which will help to inform interventions in future epidemics.
Abstract: The 2013-2016 West African epidemic caused by the Ebola virus was of unprecedented magnitude, duration and impact. Here we reconstruct the dispersal, proliferation and decline of Ebola virus throughout the region by analysing 1,610 Ebola virus genomes, which represent over 5% of the known cases. We test the association of geography, climate and demography with viral movement among administrative regions, inferring a classic 'gravity' model, with intense dispersal between larger and closer populations. Despite attenuation of international dispersal after border closures, cross-border transmission had already sown the seeds for an international epidemic, rendering these measures ineffective at curbing the epidemic. We address why the epidemic did not spread into neighbouring countries, showing that these countries were susceptible to substantial outbreaks but at lower risk of introductions. Finally, we reveal that this large epidemic was a heterogeneous and spatially dissociated collection of transmission clusters of varying size, duration and connectivity. These insights will help to inform interventions in future epidemics.
354 citations
Authors
Showing all 40485 results
Name | H-index | Papers | Citations |
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H. S. Chen | 179 | 2401 | 178529 |
John A. Rogers | 177 | 1341 | 127390 |
Omar M. Yaghi | 165 | 459 | 163918 |
Barry M. Popkin | 157 | 751 | 90453 |
John E. Morley | 154 | 1377 | 97021 |
Claude Bouchard | 153 | 1076 | 115307 |
Ruth J. F. Loos | 142 | 647 | 92485 |
Ali Khademhosseini | 140 | 887 | 76430 |
Shanhui Fan | 139 | 1292 | 82487 |
Joseph E. LeDoux | 139 | 478 | 91500 |
Christopher T. Walsh | 139 | 819 | 74314 |
Kenneth A. Dodge | 138 | 468 | 79640 |
Steven B. Heymsfield | 132 | 679 | 77220 |
George A. Bray | 131 | 896 | 100975 |
Zhanhu Guo | 128 | 886 | 53378 |