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Showing papers by "Louisiana State University published in 2017"


Journal ArticleDOI
B. P. Abbott1, Richard J. Abbott1, T. D. Abbott2, Fausto Acernese3  +1131 moreInstitutions (123)
TL;DR: The association of GRB 170817A, detected by Fermi-GBM 1.7 s after the coalescence, corroborates the hypothesis of a neutron star merger and provides the first direct evidence of a link between these mergers and short γ-ray bursts.
Abstract: On August 17, 2017 at 12∶41:04 UTC the Advanced LIGO and Advanced Virgo gravitational-wave detectors made their first observation of a binary neutron star inspiral. The signal, GW170817, was detected with a combined signal-to-noise ratio of 32.4 and a false-alarm-rate estimate of less than one per 8.0×10^{4} years. We infer the component masses of the binary to be between 0.86 and 2.26 M_{⊙}, in agreement with masses of known neutron stars. Restricting the component spins to the range inferred in binary neutron stars, we find the component masses to be in the range 1.17-1.60 M_{⊙}, with the total mass of the system 2.74_{-0.01}^{+0.04}M_{⊙}. The source was localized within a sky region of 28 deg^{2} (90% probability) and had a luminosity distance of 40_{-14}^{+8} Mpc, the closest and most precisely localized gravitational-wave signal yet. The association with the γ-ray burst GRB 170817A, detected by Fermi-GBM 1.7 s after the coalescence, corroborates the hypothesis of a neutron star merger and provides the first direct evidence of a link between these mergers and short γ-ray bursts. Subsequent identification of transient counterparts across the electromagnetic spectrum in the same location further supports the interpretation of this event as a neutron star merger. This unprecedented joint gravitational and electromagnetic observation provides insight into astrophysics, dense matter, gravitation, and cosmology.

7,327 citations


Journal ArticleDOI
B. P. Abbott1, Richard J. Abbott1, T. D. Abbott2, Fausto Acernese3  +1195 moreInstitutions (139)
TL;DR: In this paper, the authors used the observed time delay of $(+1.74\pm 0.05)\,{\rm{s}}$ between GRB 170817A and GW170817 to constrain the difference between the speed of gravity and speed of light to be between $-3
Abstract: On 2017 August 17, the gravitational-wave event GW170817 was observed by the Advanced LIGO and Virgo detectors, and the gamma-ray burst (GRB) GRB 170817A was observed independently by the Fermi Gamma-ray Burst Monitor, and the Anti-Coincidence Shield for the Spectrometer for the International Gamma-Ray Astrophysics Laboratory. The probability of the near-simultaneous temporal and spatial observation of GRB 170817A and GW170817 occurring by chance is $5.0\times {10}^{-8}$. We therefore confirm binary neutron star mergers as a progenitor of short GRBs. The association of GW170817 and GRB 170817A provides new insight into fundamental physics and the origin of short GRBs. We use the observed time delay of $(+1.74\pm 0.05)\,{\rm{s}}$ between GRB 170817A and GW170817 to: (i) constrain the difference between the speed of gravity and the speed of light to be between $-3\times {10}^{-15}$ and $+7\times {10}^{-16}$ times the speed of light, (ii) place new bounds on the violation of Lorentz invariance, (iii) present a new test of the equivalence principle by constraining the Shapiro delay between gravitational and electromagnetic radiation. We also use the time delay to constrain the size and bulk Lorentz factor of the region emitting the gamma-rays. GRB 170817A is the closest short GRB with a known distance, but is between 2 and 6 orders of magnitude less energetic than other bursts with measured redshift. A new generation of gamma-ray detectors, and subthreshold searches in existing detectors, will be essential to detect similar short bursts at greater distances. Finally, we predict a joint detection rate for the Fermi Gamma-ray Burst Monitor and the Advanced LIGO and Virgo detectors of 0.1–1.4 per year during the 2018–2019 observing run and 0.3–1.7 per year at design sensitivity.

2,633 citations


Journal ArticleDOI
B. P. Abbott1, Richard J. Abbott1, T. D. Abbott2, Fausto Acernese3  +1062 moreInstitutions (115)
TL;DR: The magnitude of modifications to the gravitational-wave dispersion relation is constrain, the graviton mass is bound to m_{g}≤7.7×10^{-23} eV/c^{2} and null tests of general relativity are performed, finding that GW170104 is consistent with general relativity.
Abstract: We describe the observation of GW170104, a gravitational-wave signal produced by the coalescence of a pair of stellar-mass black holes. The signal was measured on January 4, 2017 at 10∶11:58.6 UTC by the twin advanced detectors of the Laser Interferometer Gravitational-Wave Observatory during their second observing run, with a network signal-to-noise ratio of 13 and a false alarm rate less than 1 in 70 000 years. The inferred component black hole masses are 31.2^(8.4) _(−6.0)M_⊙ and 19.4^(5.3)_( −5.9)M_⊙ (at the 90% credible level). The black hole spins are best constrained through measurement of the effective inspiral spin parameter, a mass-weighted combination of the spin components perpendicular to the orbital plane, χ_(eff) = −0.12^(0.21)_( −0.30). This result implies that spin configurations with both component spins positively aligned with the orbital angular momentum are disfavored. The source luminosity distance is 880^(450)_(−390) Mpc corresponding to a redshift of z = 0.18^(0.08)_( −0.07) . We constrain the magnitude of modifications to the gravitational-wave dispersion relation and perform null tests of general relativity. Assuming that gravitons are dispersed in vacuum like massive particles, we bound the graviton mass to m_g ≤ 7.7 × 10^(−23) eV/c^2. In all cases, we find that GW170104 is consistent with general relativity.

2,569 citations


Journal ArticleDOI
B. P. Abbott1, Richard J. Abbott1, T. D. Abbott2, Fausto Acernese3  +1113 moreInstitutions (117)
TL;DR: For the first time, the nature of gravitational-wave polarizations from the antenna response of the LIGO-Virgo network is tested, thus enabling a new class of phenomenological tests of gravity.
Abstract: On August 14, 2017 at 10∶30:43 UTC, the Advanced Virgo detector and the two Advanced LIGO detectors coherently observed a transient gravitational-wave signal produced by the coalescence of two stellar mass black holes, with a false-alarm rate of ≲1 in 27 000 years. The signal was observed with a three-detector network matched-filter signal-to-noise ratio of 18. The inferred masses of the initial black holes are 30.5-3.0+5.7M⊙ and 25.3-4.2+2.8M⊙ (at the 90% credible level). The luminosity distance of the source is 540-210+130 Mpc, corresponding to a redshift of z=0.11-0.04+0.03. A network of three detectors improves the sky localization of the source, reducing the area of the 90% credible region from 1160 deg2 using only the two LIGO detectors to 60 deg2 using all three detectors. For the first time, we can test the nature of gravitational-wave polarizations from the antenna response of the LIGO-Virgo network, thus enabling a new class of phenomenological tests of gravity.

1,979 citations


Journal ArticleDOI
B. P. Abbott1, Richard J. Abbott1, T. D. Abbott2, Fausto Acernese3  +1151 moreInstitutions (125)
TL;DR: In this article, a GW signal from the merger of two stellar-mass black holes was observed by the two Advanced Laser Interferometer Gravitational-Wave Observatory detectors with a network signal-to-noise ratio of 13.5%.
Abstract: On 2017 June 8 at 02:01:16.49 UTC, a gravitational-wave (GW) signal from the merger of two stellar-mass black holes was observed by the two Advanced Laser Interferometer Gravitational-Wave Observatory detectors with a network signal-to-noise ratio of 13. This system is the lightest black hole binary so far observed, with component masses of ${12}_{-2}^{+7}\,{M}_{\odot }$ and ${7}_{-2}^{+2}\,{M}_{\odot }$ (90% credible intervals). These lie in the range of measured black hole masses in low-mass X-ray binaries, thus allowing us to compare black holes detected through GWs with electromagnetic observations. The source's luminosity distance is ${340}_{-140}^{+140}\,\mathrm{Mpc}$, corresponding to redshift ${0.07}_{-0.03}^{+0.03}$. We verify that the signal waveform is consistent with the predictions of general relativity.

1,268 citations


Journal ArticleDOI
TL;DR: Treatments for obesity include behavioral therapy, pharmacotherapy, and bariatric surgery, and some sequelae of obesity are reversed with weight loss.
Abstract: Obesity is prevalent in the U.S. population and contributes significantly to morbidity and mortality. Treatments include behavioral therapy, pharmacotherapy, and bariatric surgery. Some sequelae of obesity are reversed with weight loss. Maintaining weight loss is a challenge.

1,093 citations


Book
06 Feb 2017
TL;DR: The author develops all of the tools necessary for understanding important results in quantum information theory, including capacity theorems for classical, entanglement-assisted, private and quantum communication.
Abstract: Finally, here is a modern, self-contained text on quantum information theory suitable for graduate-level courses. Developing the subject 'from the ground up' it covers classical results as well as major advances of the past decade. Beginning with an extensive overview of classical information theory suitable for the non-expert, the author then turns his attention to quantum mechanics for quantum information theory, and the important protocols of teleportation, super-dense coding and entanglement distribution. He develops all of the tools necessary for understanding important results in quantum information theory, including capacity theorems for classical, entanglement-assisted, private and quantum communication. The book also covers important recent developments such as superadditivity of private, coherent and Holevo information, and the superactivation of quantum capacity. This book will be warmly welcomed by the upcoming generation of quantum information theorists and the already established community of classical information theorists.

1,035 citations


Journal ArticleDOI
B. P. Abbott1, Richard J. Abbott1, T. D. Abbott2, Fausto Acernese3  +1319 moreInstitutions (78)
02 Nov 2017-Nature
TL;DR: A measurement of the Hubble constant is reported that combines the distance to the source inferred purely from the gravitational-wave signal with the recession velocity inferred from measurements of the redshift using the electromagnetic data.
Abstract: On 17 August 2017, the Advanced LIGO1 and Virgo2 detectors observed the gravitational-wave event GW170817—a strong signal from the merger of a binary neutron-star system3. Less than two seconds after the merger, a γ-ray burst (GRB 170817A) was detected within a region of the sky consistent with the LIGO–Virgo-derived location of the gravitational-wave source4, 5, 6. This sky region was subsequently observed by optical astronomy facilities7, resulting in the identification8, 9, 10, 11, 12, 13 of an optical transient signal within about ten arcseconds of the galaxy NGC 4993. This detection of GW170817 in both gravitational waves and electromagnetic waves represents the first ‘multi-messenger’ astronomical observation. Such observations enable GW170817 to be used as a ‘standard siren’14, 15, 16, 17, 18 (meaning that the absolute distance to the source can be determined directly from the gravitational-wave measurements) to measure the Hubble constant. This quantity represents the local expansion rate of the Universe, sets the overall scale of the Universe and is of fundamental importance to cosmology. Here we report a measurement of the Hubble constant that combines the distance to the source inferred purely from the gravitational-wave signal with the recession velocity inferred from measurements of the redshift using the electromagnetic data. In contrast to previous measurements, ours does not require the use of a cosmic ‘distance ladder’19: the gravitational-wave analysis can be used to estimate the luminosity distance out to cosmological scales directly, without the use of intermediate astronomical distance measurements. We determine the Hubble constant to be about 70 kilometres per second per megaparsec. This value is consistent with existing measurements20, 21, while being completely independent of them. Additional standard siren measurements from future gravitational-wave sources will enable the Hubble constant to be constrained to high precision.

892 citations


Journal ArticleDOI
B. P. Abbott1, Richard J. Abbott1, T. D. Abbott2, M. R. Abernathy3  +719 moreInstitutions (86)
Abstract: The second-generation of gravitational-wave detectors are just starting operation, and have already yielding their first detections. Research is now concentrated on how to maximize the scientific potential of gravitational-wave astronomy. To support this effort, we present here design targets for a new generation of detectors, which will be capable of observing compact binary sources with high signal-to-noise ratio throughout the Universe.

796 citations


Journal ArticleDOI
TL;DR: The argument for obesity as a chronic relapsing disease process is considered, with food the primary agent, particularly foods that are high in energy density such as fat, or in sugar‐sweetened beverages.
Abstract: This paper considers the argument for obesity as a chronic relapsing disease process. Obesity is viewed from an epidemiological model, with an agent affecting the host and producing disease. Food is the primary agent, particularly foods that are high in energy density such as fat, or in sugar-sweetened beverages. An abundance of food, low physical activity and several other environmental factors interact with the genetic susceptibility of the host to produce positive energy balance. The majority of this excess energy is stored as fat in enlarged, and often more numerous fat cells, but some lipid may infiltrate other organs such as the liver (ectopic fat). The enlarged fat cells and ectopic fat produce and secrete a variety of metabolic, hormonal and inflammatory products that produce damage in organs such as the arteries, heart, liver, muscle and pancreas. The magnitude of the obesity and its adverse effects in individuals may relate to the virulence or toxicity of the environment and its interaction with the host. Thus, obesity fits the epidemiological model of a disease process except that the toxic or pathological agent is food rather than a microbe. Reversing obesity will prevent most of its detrimental effects.

721 citations


Journal ArticleDOI
TL;DR: Studies have shown that adiponectin administration in humans and rodents has insulin-sensitizing, anti-atherogenic, and anti-inflammatory effects, and, in certain settings, also decreases body weight, thus suggesting potential versatile therapeutic targets in the treatment of obesity, insulin resistance/type 2 diabetes, and atherosclerosis.
Abstract: Adiponectin is the most abundant peptide secreted by adipocytes, whose reduction plays a central role in obesity-related diseases, including insulin resistance/type 2 diabetes and cardiovascular disease. In addition to adipocytes, other cell types, such as skeletal and cardiac myocytes and endothelial cells, can also produce this adipocytokine. Adiponectin effects are mediated by adiponectin receptors, which occur as two isoforms (AdipoR1 and AdipoR2). Adiponectin has direct actions in liver, skeletal muscle, and the vasculature.Adiponectin exists in the circulation as varying molecular weight forms, produced by multimerization. Several endoplasmic reticulum ER-associated proteins, including ER oxidoreductase 1-α (Ero1-α), ER resident protein 44 (ERp44), disulfide-bond A oxidoreductase-like protein (DsbA-L), and glucose-regulated protein 94 (GPR94), have recently been found to be involved in the assembly and secretion of higher-order adiponectin complexes. Recent data indicate that the high-molecular weight (HMW) complexes have the predominant action in metabolic tissues. Studies have shown that adiponectin administration in humans and rodents has insulin-sensitizing, anti-atherogenic, and anti-inflammatory effects, and, in certain settings, also decreases body weight. Therefore, adiponectin replacement therapy in humans may suggest potential versatile therapeutic targets in the treatment of obesity, insulin resistance/type 2 diabetes, and atherosclerosis. The current knowledge on regulation and function of adiponectin in obesity, insulin resistance, and cardiovascular disease is summarized in this review.

Journal ArticleDOI
TL;DR: The effectiveness of engagement marketing arises from the establishment of psychological ownership and self-transformation as discussed by the authors, and the authors provide evidence in support of the derived tenets through case illustrations, as well as a quasi-experimental field test of the central tenet.
Abstract: Customer engagement marketing—defined as a firm’s deliberate effort to motivate, empower, and measure customer contributions to marketing functions—marks a shift in marketing research and business practice. After defining and differentiating engagement marketing, the authors present a typology of its two primary forms and offer tenets that link specific strategic elements to customer outcomes and thereby firm performance, theorizing that the effectiveness of engagement marketing arises from the establishment of psychological ownership and self-transformation. The authors provide evidence in support of the derived tenets through case illustrations, as well as a quasi-experimental field test of the central tenet of engagement marketing.

Journal ArticleDOI
TL;DR: A systematic review of the unpublished and published, peer-reviewed literature examining the relationship between interpersonal theory constructs and suicidal thoughts and behaviors supported the interpersonal theory; and alternative configurations of theory variables were similarly useful for predicting suicide risk as theory-consistent pathways.
Abstract: Over the past decade, the interpersonal theory of suicide has contributed to substantial advances in the scientific and clinical understanding of suicide and related conditions. The interpersonal theory of suicide posits that suicidal desire emerges when individuals experience intractable feelings of perceived burdensomeness and thwarted belongingness and near-lethal or lethal suicidal behavior occurs in the presence of suicidal desire and capability for suicide. A growing number of studies have tested these posited pathways in various samples; however, these findings have yet to be evaluated meta-analytically. This paper aimed to (a) conduct a systematic review of the unpublished and published, peer-reviewed literature examining the relationship between interpersonal theory constructs and suicidal thoughts and behaviors, (b) conduct meta-analyses testing the interpersonal theory hypotheses, and (c) evaluate the influence of various moderators on these relationships. Four electronic bibliographic databases were searched through the end of March, 2016: PubMed, Medline, PsycINFO, and Web of Science. Hypothesis-driven meta-analyses using random effects models were conducted using 122 distinct unpublished and published samples. Findings supported the interpersonal theory: the interaction between thwarted belongingness and perceived burdensomeness was significantly associated with suicidal ideation; and the interaction between thwarted belongingness, perceived burdensomeness, and capability for suicide was significantly related to a greater number of prior suicide attempts. However, effect sizes for these interactions were modest. Alternative configurations of theory variables were similarly useful for predicting suicide risk as theory-consistent pathways. We conclude with limitations and recommendations for the interpersonal theory as a framework for understanding the suicidal spectrum. (PsycINFO Database Record

Journal ArticleDOI
TL;DR: In this paper, the authors identify four foundational elements that characterize this emerging neoconfigurational perspective: 1) conceptualizing cases as set theoretic configurations; 2) calibrating cases' memberships into sets; 3) viewing causality in terms of necessity and sufficiency relations between sets; and 4) conducting counterfactual analysis of unobserved configurations.

Journal ArticleDOI
TL;DR: The Southampton Guidelines have amalgamated the available evidence and a wealth of experts’ knowledge taking in consideration the relevant stakeholders’ opinions and complying with the international methodology standards.
Abstract: Objective:The European Guidelines Meeting on Laparoscopic Liver Surgery was held in Southampton on February 10 and 11, 2017 with the aim of presenting and validating clinical practice guidelines for laparoscopic liver surgery.Background:The exponential growth of laparoscopic liver surgery in recent

Journal ArticleDOI
A. Aab1, P. Abreu2, Marco Aglietta3, I. Al Samarai4  +415 moreInstitutions (65)
22 Sep 2017-Science
TL;DR: The Pierre Auger Collaboration reports the observation of thousands of cosmic rays with ultrahigh energies of several exa–electron volts, arriving in a slightly dipolar distribution, showing that they originate outside the Milky Way Galaxy.
Abstract: Cosmic rays are atomic nuclei arriving from outer space that reach the highest energies observed in nature Clues to their origin come from studying the distribution of their arrival directions Using 3 × 10 4 cosmic rays with energies above 8 × 10 18 electron volts, recorded with the Pierre Auger Observatory from a total exposure of 76,800 km 2 sr year, we determined the existence of anisotropy in arrival directions The anisotropy, detected at more than a 52σ level of significance, can be described by a dipole with an amplitude of 65 − 09 + 13 percent toward right ascension α d = 100 ± 10 degrees and declination δ d = − 24 − 13 + 12 degrees That direction indicates an extragalactic origin for these ultrahigh-energy particles

Journal ArticleDOI
Gytis Dudas1, Gytis Dudas2, Luiz Max Carvalho1, Trevor Bedford2, Andrew J. Tatem3, Guy Baele4, Nuno R. Faria5, Daniel J. Park6, Jason T. Ladner7, Armando Arias8, Armando Arias9, Danny Asogun, Filip Bielejec4, Sarah L Caddy8, Matthew Cotten10, Matthew Cotten11, Jonathan D'ambrozio7, Simon Dellicour4, Antonino Di Caro, Joseph W. Diclaro, Sophie Duraffour12, Michael J. Elmore13, Lawrence Fakoli, Ousmane Faye14, Merle L. Gilbert7, Sahr M. Gevao15, Stephen K. Gire6, Stephen K. Gire16, Adrianne Gladden-Young6, Andreas Gnirke6, Augustine Goba, Donald S. Grant, Bart L. Haagmans10, Julian A. Hiscox17, Umaru Jah18, Jeffrey R. Kugelman7, Di Liu, Jia Lu8, Christine M. Malboeuf6, Suzanne Mate7, David A. Matthews19, Christian B. Matranga6, Luke W. Meredith18, Luke W. Meredith8, James Qu6, Joshua Quick20, Susan D. Pas10, My V. T. Phan10, My V. T. Phan11, Georgios Pollakis17, Chantal B.E.M. Reusken10, Mariano Sanchez-Lockhart7, Stephen F. Schaffner6, John S. Schieffelin, Rachel Sealfon21, Rachel Sealfon6, Etienne Simon-Loriere22, Etienne Simon-Loriere14, Saskia L. Smits10, Kilian Stoecker, Lucy Thorne8, Ekaete Alice Tobin, Mohamed A. Vandi, Simon J. Watson11, Kendra West6, Shannon L.M. Whitmer, Michael R. Wiley7, Sarah M. Winnicki23, Sarah M. Winnicki6, Shirlee Wohl6, Shirlee Wohl16, Roman Wölfel, Nathan L. Yozwiak16, Nathan L. Yozwiak6, Kristian G. Andersen24, Kristian G. Andersen25, Sylvia O. Blyden, Fatorma K. Bolay, Miles W. Carroll, Bernice Dahn, Boubacar Diallo26, Pierre Formenty26, Christophe Fraser5, George F. Gao27, Robert F. Garry, Ian Goodfellow8, Ian Goodfellow18, Stephan Günther12, Christian T. Happi, Edward C. Holmes28, Brima Kargbo, Sakoba Keita, Paul Kellam29, Paul Kellam11, Marion Koopmans10, Jens H. Kuhn30, Nicholas J. Loman20, N’Faly Magassouba, Dhamari Naidoo26, Stuart T. Nichol31, Tolbert Nyenswah, Gustavo Palacios7, Oliver G. Pybus5, Pardis C. Sabeti6, Pardis C. Sabeti16, Amadou A. Sall14, Ute Ströher31, Isatta Wurie15, Marc A. Suchard32, Philippe Lemey4, Andrew Rambaut1 
20 Apr 2017-Nature
TL;DR: It is revealed that this large epidemic was a heterogeneous and spatially dissociated collection of transmission clusters of varying size, duration and connectivity, which will help to inform interventions in future epidemics.
Abstract: The 2013-2016 West African epidemic caused by the Ebola virus was of unprecedented magnitude, duration and impact. Here we reconstruct the dispersal, proliferation and decline of Ebola virus throughout the region by analysing 1,610 Ebola virus genomes, which represent over 5% of the known cases. We test the association of geography, climate and demography with viral movement among administrative regions, inferring a classic 'gravity' model, with intense dispersal between larger and closer populations. Despite attenuation of international dispersal after border closures, cross-border transmission had already sown the seeds for an international epidemic, rendering these measures ineffective at curbing the epidemic. We address why the epidemic did not spread into neighbouring countries, showing that these countries were susceptible to substantial outbreaks but at lower risk of introductions. Finally, we reveal that this large epidemic was a heterogeneous and spatially dissociated collection of transmission clusters of varying size, duration and connectivity. These insights will help to inform interventions in future epidemics.

Journal ArticleDOI
TL;DR: Measuring the photocurrent response to circularly polarized mid-infrared light provides direct access to the chirality of Weyl fermions in Weyl semimetals.
Abstract: Measuring the photocurrent response to circularly polarized mid-infrared light provides direct access to the chirality of Weyl fermions in Weyl semimetals — the property responsible for a range of exotic phenomena.

Journal ArticleDOI
TL;DR: The effects of CR in non-obese humans on physiological parameters of energy metabolism and metabolic risk factors of age-associated disease in great detail are discussed.

Journal ArticleDOI
TL;DR: There is unequivocal evidence that ants are the sister group to bees+apoid wasps (Apoidea) and that bees are nested within a paraphyletic Crabronidae, and that taxon choice can fundamentally impact tree topology and clade support in phylogenomic inference.

Journal ArticleDOI
TL;DR: The results showed that soils were highly contaminated by residual tailings and previous mining activities, and local residents had high chronic risks due to the intake of Hg and Pb, while their carcinogenic risk associated with Cd through inhalation was low.

Journal ArticleDOI
TL;DR: Results show that semantic web technologies have a key role to play in logic-based applications and applications that require information from multiple application areas and devising beneficial implementation approaches that rely on appropriate combinations of declarative and procedural programming techniques, semantic and legacy data formats, user input, and automated procedures.

Journal ArticleDOI
B. P. Abbott1, Richard J. Abbott1, Richard J. Abbott2, T. D. Abbott3  +1064 moreInstitutions (117)
TL;DR: This work performs a search for the isotropic stochastic gravitational-wave background using data from Advanced Laser Interferometer Gravitational Wave Observatory's (aLIGO) first observing run, and constrain the dimensionless energy density of gravitational waves to be Ω_{0}<1.7×10^{-7} with 95% confidence.
Abstract: A wide variety of astrophysical and cosmological sources are expected to contribute to a stochastic gravitational-wave background. Following the observations of GW150914 and GW151226, the rate and mass of coalescing binary black holes appear to be greater than many previous expectations. As a result, the stochastic background from unresolved compact binary coalescences is expected to be particularly loud. We perform a search for the isotropic stochastic gravitational-wave background using data from Advanced Laser Interferometer Gravitational Wave Observatory’s (aLIGO) first observing run. The data display no evidence of a stochastic gravitational-wave signal. We constrain the dimensionless energy density of gravitational waves to be Ω 0 < 1.7 × 10 − 7 with 95% confidence, assuming a flat energy density spectrum in the most sensitive part of the LIGO band (20–86 Hz). This is a factor of ∼ 33 times more sensitive than previous measurements. We also constrain arbitrary power-law spectra. Finally, we investigate the implications of this search for the background of binary black holes using an astrophysical model for the background.

Journal ArticleDOI
TL;DR: The presence of bacterial lipopolysaccharide (LPS) in brain lysates from the hippocampus and superior temporal lobe neocortex of Alzheimer's disease (AD) brains is reported for the first time.
Abstract: Although the potential contribution of the human gastrointestinal (GI) tract microbiome to human health, aging and disease is becoming increasingly acknowledged, the molecular mechanics and signaling pathways of just how this is accomplished is not well understood. Major bacterial species of the GI tract, such as the abundant Gram-negative bacilli Bacteroides fragilis (B. fragilis) and Escherichia coli (E. coli), secrete a remarkably complex array of pro-inflammatory neurotoxins which, when released from the confines of the healthy GI tract, are pathogenic and highly detrimental to the homeostatic function of neurons in the central nervous system (CNS). For the first time here we report the presence of bacterial lipopolysaccharide (LPS) in brain lysates from the hippocampus and superior temporal lobe neocortex of Alzheimer’s disease (AD) brains. Mean LPS levels varied from 2-fold increases in the neocortex to 3-fold increases in the hippocampus, AD over age-matched controls, however some samples from advanced AD hippocampal cases exhibited up to a 26-fold increase in LPS over age-matched controls. This ‘Perspectives’ paper will further highlight some very recent research on GI tract microbiome signaling to the human CNS, and will update current findings that implicate GI tract microbiome-derived LPS as an important internal contributor to inflammatory degeneration in the CNS.

Journal ArticleDOI
Julien Emile-Geay1, Nicholas P. McKay2, Darrell S. Kaufman2, Lucien von Gunten, Jianghao Wang3, Kevin J. Anchukaitis4, Nerilie J. Abram5, Jason A. Addison6, Mark A. J. Curran7, Mark A. J. Curran8, Michael N. Evans9, Benjamin J. Henley10, Zhixin Hao, Belen Martrat11, Belen Martrat12, Helen McGregor13, Raphael Neukom14, Gregory T. Pederson6, Barbara Stenni15, Kaustubh Thirumalai16, Johannes P. Werner17, Chenxi Xu18, Dmitry Divine19, Bronwyn C. Dixon10, Joelle Gergis10, Ignacio A. Mundo20, Takeshi Nakatsuka, Steven J. Phipps8, Cody C. Routson2, Eric J. Steig21, Jessica E. Tierney4, Jonathan J. Tyler22, Kathryn Allen10, Nancy A. N. Bertler23, Jesper Björklund24, Brian M. Chase25, Min Te Chen26, Edward R. Cook27, Rixt de Jong14, Kristine L. DeLong28, Daniel A. Dixon29, Alexey A. Ekaykin30, Alexey A. Ekaykin31, Vasile Ersek32, Helena L. Filipsson33, Pierre Francus34, Mandy Freund10, Massimo Frezzotti, Narayan Prasad Gaire35, Narayan Prasad Gaire36, Konrad Gajewski37, Quansheng Ge, Hugues Goosse38, Anastasia Gornostaeva, Martin Grosjean14, Kazuho Horiuchi39, Anne Hormes40, Katrine Husum19, Elisabeth Isaksson19, Selvaraj Kandasamy41, Kenji Kawamura42, Kenji Kawamura43, K. Halimeda Kilbourne9, Nalan Koc19, Guillaume Leduc44, Hans W. Linderholm40, Andrew Lorrey45, Vladimir Mikhalenko46, P. Graham Mortyn47, Hideaki Motoyama42, Andrew D. Moy8, Andrew D. Moy7, Robert Mulvaney48, Philipp Munz49, David J. Nash50, David J. Nash51, Hans Oerter52, Thomas Opel52, Anais Orsi53, Dmitriy V. Ovchinnikov54, Trevor J. Porter55, Heidi A. Roop56, Casey Saenger21, Masaki Sano, David J. Sauchyn38, Krystyna M. Saunders14, Krystyna M. Saunders57, Marit-Solveig Seidenkrantz58, Mirko Severi59, Xuemei Shao, Marie-Alexandrine Sicre60, Michael Sigl61, Kate E. Sinclair, Scott St. George62, Jeannine-Marie St. Jacques63, Jeannine-Marie St. Jacques64, Meloth Thamban65, Udya Kuwar Thapa62, Elizabeth R. Thomas48, Chris S. M. Turney66, Ryu Uemura67, A. E. Viau37, Diana Vladimirova31, Diana Vladimirova30, Eugene R. Wahl68, James W. C. White69, Zicheng Yu70, Jens Zinke71, Jens Zinke72 
University of Southern California1, Northern Arizona University2, MathWorks3, University of Arizona4, Australian National University5, United States Geological Survey6, Australian Antarctic Division7, University of Tasmania8, University of Maryland, College Park9, University of Melbourne10, Spanish National Research Council11, University of Cambridge12, University of Wollongong13, University of Bern14, Ca' Foscari University of Venice15, University of Texas at Austin16, University of Bergen17, Chinese Academy of Sciences18, Norwegian Polar Institute19, National University of Cuyo20, University of Washington21, University of Adelaide22, Victoria University of Wellington23, Swiss Federal Institute for Forest, Snow and Landscape Research24, University of Montpellier25, National Taiwan Ocean University26, Columbia University27, Louisiana State University28, University of Maine29, Saint Petersburg State University30, Arctic and Antarctic Research Institute31, Northumbria University32, Lund University33, Institut national de la recherche scientifique34, Nepal Academy of Science and Technology35, Tribhuvan University36, University of Ottawa37, Université catholique de Louvain38, Hirosaki University39, University of Gothenburg40, Xiamen University41, National Institute of Polar Research42, Japan Agency for Marine-Earth Science and Technology43, Aix-Marseille University44, National Institute of Water and Atmospheric Research45, Russian Academy of Sciences46, Autonomous University of Barcelona47, British Antarctic Survey48, University of Tübingen49, University of Brighton50, University of the Witwatersrand51, Alfred Wegener Institute for Polar and Marine Research52, Université Paris-Saclay53, Sukachev Institute of Forest54, University of Toronto55, University at Buffalo56, Australian Nuclear Science and Technology Organisation57, Aarhus University58, University of Florence59, Pierre-and-Marie-Curie University60, Paul Scherrer Institute61, University of Minnesota62, University of Regina63, Concordia University64, National Centre for Antarctic and Ocean Research65, University of New South Wales66, University of the Ryukyus67, National Oceanic and Atmospheric Administration68, University of Colorado Boulder69, Lehigh University70, Free University of Berlin71, Australian Institute of Marine Science72
TL;DR: A community-sourced database of temperature-sensitive proxy records from the PAGES2k initiative, suited to investigations of global and regional temperature variability over the Common Era, and is shared in the Linked Paleo Data (LiPD) format, including serializations in Matlab, R and Python.
Abstract: Reproducible climate reconstructions of the Common Era (1 CE to present) are key to placing industrial-era warming into the context of natural climatic variability. Here we present a community-sourced database of temperature-sensitive proxy records from the PAGES2k initiative. The database gathers 692 records from 648 locations, including all continental regions and major ocean basins. The records are from trees, ice, sediment, corals, speleothems, documentary evidence, and other archives. They range in length from 50 to 2000 years, with a median of 547 years, while temporal resolution ranges from biweekly to centennial. Nearly half of the proxy time series are significantly correlated with HadCRUT4.2 surface temperature over the period 1850–2014. Global temperature composites show a remarkable degree of coherence between high- and low-resolution archives, with broadly similar patterns across archive types, terrestrial versus marine locations, and screening criteria. The database is suited to investigations of global and regional temperature variability over the Common Era, and is shared in the Linked Paleo Data (LiPD) format, including serializations in Matlab, R and Python.

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TL;DR: The formation and resolution of the internal spin structure of room temperature skyrmions without a stabilizing out-of-plane field in thick magnetic multilayers opens up a new set of tools and materials to study the physics and device applications associated with chiral ordering and skyrMions.
Abstract: Neel skyrmions are of high interest due to their potential applications in a variety of spintronic devices, currently accessible in ultrathin heavy metal/ferromagnetic bilayers and multilayers with a strong Dzyaloshinskii–Moriya interaction. Here we report on the direct imaging of chiral spin structures including skyrmions in an exchange-coupled cobalt/palladium multilayer at room temperature with Lorentz transmission electron microscopy, a high-resolution technique previously suggested to exhibit no Neel skyrmion contrast. Phase retrieval methods allow us to map the internal spin structure of the skyrmion core, identifying a 25 nm central region of uniform magnetization followed by a larger region characterized by rotation from in- to out-of-plane. The formation and resolution of the internal spin structure of room temperature skyrmions without a stabilizing out-of-plane field in thick magnetic multilayers opens up a new set of tools and materials to study the physics and device applications associated with chiral ordering and skyrmions. Neel skyrmions are spin textures with a magnetization that rotates from in- to out-of-plane with distance from its centre. Here, the authors show that Lorentz transmission electron microscopy can be used to directly image Neel skyrmions with high resolution in thick exchange-coupled magnetic multilayers.

Journal ArticleDOI
05 Jun 2017-Nature
TL;DR: Observations of the bright star HD 195689 are reported, which reveal a close-in (orbital period of about 1.48 days) transiting giant planet, KELT-9b, which is as hot as stars of stellar type K4 and receives 700 times more extreme-ultraviolet radiation than WASP-33b.
Abstract: The amount of ultraviolet irradiation and ablation experienced by a planet depends strongly on the temperature of its host star. Of the thousands of extrasolar planets now known, only six have been found that transit hot, A-type stars (with temperatures of 7,300–10,000 kelvin), and no planets are known to transit the even hotter B-type stars. For example, WASP-33 is an A-type star with a temperature of about 7,430 kelvin, which hosts the hottest known transiting planet, WASP-33b (ref. 1); the planet is itself as hot as a red dwarf star of type M (ref. 2). WASP-33b displays a large heat differential between its dayside and nightside, and is highly inflated–traits that have been linked to high insolation. However, even at the temperature of its dayside, its atmosphere probably resembles the molecule-dominated atmospheres of other planets and, given the level of ultraviolet irradiation it experiences, its atmosphere is unlikely to be substantially ablated over the lifetime of its star. Here we report observations of the bright star HD 195689 (also known as KELT-9), which reveal a close-in (orbital period of about 1.48 days) transiting giant planet, KELT-9b. At approximately 10,170 kelvin, the host star is at the dividing line between stars of type A and B, and we measure the dayside temperature of KELT-9b to be about 4,600 kelvin. This is as hot as stars of stellar type K4 (ref. 5). The molecules in K stars are entirely dissociated, and so the primary sources of opacity in the dayside atmosphere of KELT-9b are probably atomic metals. Furthermore, KELT-9b receives 700 times more extreme-ultraviolet radiation (that is, with wavelengths shorter than 91.2 nanometres) than WASP-33b, leading to a predicted range of mass-loss rates that could leave the planet largely stripped of its envelope during the main-sequence lifetime of the host star.

Journal ArticleDOI
B. P. Abbott1, Richard J. Abbott1, T. D. Abbott2, Fausto Acernese3  +1137 moreInstitutions (125)
TL;DR: In this paper, the authors presented a search for GWs from the remnant of the binary neutron star merger GW170817 using data from Advanced LIGO and Advanced Virgo.
Abstract: The first observation of a binary neutron star (NS) coalescence by the Advanced LIGO and Advanced Virgo gravitational-wave (GW) detectors offers an unprecedented opportunity to study matter under the most extreme conditions. After such a merger, a compact remnant is left over whose nature depends primarily on the masses of the inspiraling objects and on the equation of state of nuclear matter. This could be either a black hole (BH) or an NS, with the latter being either long-lived or too massive for stability implying delayed collapse to a BH. Here, we present a search for GWs from the remnant of the binary NS merger GW170817 using data from Advanced LIGO and Advanced Virgo. We search for short- (lesssim1 s) and intermediate-duration (lesssim500 s) signals, which include GW emission from a hypermassive NS or supramassive NS, respectively. We find no signal from the post-merger remnant. Our derived strain upper limits are more than an order of magnitude larger than those predicted by most models. For short signals, our best upper limit on the root sum square of the GW strain emitted from 1–4 kHz is ${h}_{\mathrm{rss}}^{50 \% }=2.1\times {10}^{-22}\,{\mathrm{Hz}}^{-1/2}$ at 50% detection efficiency. For intermediate-duration signals, our best upper limit at 50% detection efficiency is ${h}_{\mathrm{rss}}^{50 \% }=8.4\times {10}^{-22}\,{\mathrm{Hz}}^{-1/2}$ for a millisecond magnetar model, and ${h}_{\mathrm{rss}}^{50 \% }=5.9\times {10}^{-22}\,{\mathrm{Hz}}^{-1/2}$ for a bar-mode model. These results indicate that post-merger emission from a similar event may be detectable when advanced detectors reach design sensitivity or with next-generation detectors.

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TL;DR: In this article, an introductory overview of the various ways in which feedback may be implemented in quantum systems, the theoretical methods that are currently used to treat it, the experiments in which it has been demonstrated to date, and its applications.

Journal ArticleDOI
TL;DR: In this article, a polypyrrole functionalized nano-magnetite (Fe3O4-PPy) was used to enhance the electromagnetic wave absorption performance and flame retardancy.
Abstract: Epoxy nanocomposites reinforced with polypyrrole functionalized nano-magnetite (Fe3O4–PPy) showed significantly enhanced electromagnetic wave absorption performance and flame retardancy. The Fe3O4–PPy nanocomposites were prepared by the surface initiated polymerization method. The epoxy/(30.0 wt%)Fe3O4–PPy nanocomposites possess a minimum reflection loss (RL) value of −35.7 dB, which is much lower than that of either epoxy/(7.5 wt%)PPy nanocomposites with a minimum RL value of −11.0 dB or epoxy/(30.0 wt%)Fe3O4 with a minimum RL value of −17.8 dB at the same thickness (1.7 mm). Meanwhile, the bandwidth of epoxy/(30.0 wt%)Fe3O4–PPy nanocomposites for RL < −10 dB and RL < −20 dB is 4.0 GHz and 0.8 GHz, respectively. The increased interface area, eddy current loss and anisotropic energy are essentially important to achieve higher reflection loss and broader absorption bandwidth for epoxy/(30.0 wt%)Fe3O4–PPy nanocomposites. Moreover, the significantly reduced flammability was observed in the epoxy/(30.0 wt%)Fe3O4–PPy nanocomposites compared with pure epoxy. The total heat release of epoxy/(30.0 wt%)Fe3O4–PPy nanocomposites decreased from 25.5 kJ g−1 of pure epoxy to just 12.3 kJ g−1. The tensile strength of the epoxy nanocomposites was reported as well. These new nanocomposites with an enhanced electromagnetic wave absorption property and flame retardancy possess great potential for safer electromagnetic wave absorbers in the electronic industry to satisfy stringent industrial standards.