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Showing papers by "Polytechnic University of Catalonia published in 2019"


Posted ContentDOI
03 Oct 2019-bioRxiv
TL;DR: Analysis of the v8 data provides insights into the tissue-specificity of genetic effects, and shows that cell type composition is a key factor in understanding gene regulatory mechanisms in human tissues.
Abstract: The Genotype-Tissue Expression (GTEx) project was established to characterize genetic effects on the transcriptome across human tissues, and to link these regulatory mechanisms to trait and disease associations. Here, we present analyses of the v8 data, based on 17,382 RNA-sequencing samples from 54 tissues of 948 post-mortem donors. We comprehensively characterize genetic associations for gene expression and splicing in cis and trans, showing that regulatory associations are found for almost all genes, and describe the underlying molecular mechanisms and their contribution to allelic heterogeneity and pleiotropy of complex traits. Leveraging the large diversity of tissues, we provide insights into the tissue-specificity of genetic effects, and show that cell type composition is a key factor in understanding gene regulatory mechanisms in human tissues.

1,243 citations


Journal ArticleDOI
A. Abada1, Marcello Abbrescia2, Marcello Abbrescia3, Shehu S. AbdusSalam4  +1491 moreInstitutions (239)
TL;DR: In this article, the authors present the second volume of the Future Circular Collider Conceptual Design Report, devoted to the electron-positron collider FCC-ee, and present the accelerator design, performance reach, a staged operation scenario, the underlying technologies, civil engineering, technical infrastructure, and an implementation plan.
Abstract: In response to the 2013 Update of the European Strategy for Particle Physics, the Future Circular Collider (FCC) study was launched, as an international collaboration hosted by CERN. This study covers a highest-luminosity high-energy lepton collider (FCC-ee) and an energy-frontier hadron collider (FCC-hh), which could, successively, be installed in the same 100 km tunnel. The scientific capabilities of the integrated FCC programme would serve the worldwide community throughout the 21st century. The FCC study also investigates an LHC energy upgrade, using FCC-hh technology. This document constitutes the second volume of the FCC Conceptual Design Report, devoted to the electron-positron collider FCC-ee. After summarizing the physics discovery opportunities, it presents the accelerator design, performance reach, a staged operation scenario, the underlying technologies, civil engineering, technical infrastructure, and an implementation plan. FCC-ee can be built with today’s technology. Most of the FCC-ee infrastructure could be reused for FCC-hh. Combining concepts from past and present lepton colliders and adding a few novel elements, the FCC-ee design promises outstandingly high luminosity. This will make the FCC-ee a unique precision instrument to study the heaviest known particles (Z, W and H bosons and the top quark), offering great direct and indirect sensitivity to new physics.

526 citations


Book ChapterDOI
01 Jan 2019
TL;DR: This chapter introduces the basic concepts, the operation of the power converters, and the performance of the control schemes in AC microgrids with a complete description of the most important control loops in αβ stationary reference frame.
Abstract: This chapter introduces the basic concepts, the operation of the power converters, and the performance of the control schemes in AC microgrids. First, the power converters are classified according to the main function performed either as grid-feeding converters or as grid-forming converters. Second, a complete description of the most important control loops in αβ stationary reference frame is presented. Finally, the chapter concludes with key findings and remarks on the control schemes.

483 citations


Proceedings ArticleDOI
02 Aug 2019
TL;DR: This paper presents the results of the premier shared task organized alongside the Conference on Machine Translation (WMT) 2019, asked to build machine translation systems for any of 18 language pairs, to be evaluated on a test set of news stories.
Abstract: This paper presents the results of the premier shared task organized alongside the Conference on Machine Translation (WMT) 2019. Participants were asked to build machine translation systems for any of 18 language pairs, to be evaluated on a test set of news stories. The main metric for this task is human judgment of translation quality. The task was also opened up to additional test suites to probe specific aspects of translation.

433 citations


Journal ArticleDOI
A. Abada1, Marcello Abbrescia2, Marcello Abbrescia3, Shehu S. AbdusSalam4  +1496 moreInstitutions (238)
TL;DR: In this paper, the authors describe the detailed design and preparation of a construction project for a post-LHC circular energy frontier collider in collaboration with national institutes, laboratories and universities worldwide, and enhanced by a strong participation of industrial partners.
Abstract: Particle physics has arrived at an important moment of its history. The discovery of the Higgs boson, with a mass of 125 GeV, completes the matrix of particles and interactions that has constituted the “Standard Model” for several decades. This model is a consistent and predictive theory, which has so far proven successful at describing all phenomena accessible to collider experiments. However, several experimental facts do require the extension of the Standard Model and explanations are needed for observations such as the abundance of matter over antimatter, the striking evidence for dark matter and the non-zero neutrino masses. Theoretical issues such as the hierarchy problem, and, more in general, the dynamical origin of the Higgs mechanism, do likewise point to the existence of physics beyond the Standard Model. This report contains the description of a novel research infrastructure based on a highest-energy hadron collider with a centre-of-mass collision energy of 100 TeV and an integrated luminosity of at least a factor of 5 larger than the HL-LHC. It will extend the current energy frontier by almost an order of magnitude. The mass reach for direct discovery will reach several tens of TeV, and allow, for example, to produce new particles whose existence could be indirectly exposed by precision measurements during the earlier preceding e+e– collider phase. This collider will also precisely measure the Higgs self-coupling and thoroughly explore the dynamics of electroweak symmetry breaking at the TeV scale, to elucidate the nature of the electroweak phase transition. WIMPs as thermal dark matter candidates will be discovered, or ruled out. As a single project, this particle collider infrastructure will serve the world-wide physics community for about 25 years and, in combination with a lepton collider (see FCC conceptual design report volume 2), will provide a research tool until the end of the 21st century. Collision energies beyond 100 TeV can be considered when using high-temperature superconductors. The European Strategy for Particle Physics (ESPP) update 2013 stated “To stay at the forefront of particle physics, Europe needs to be in a position to propose an ambitious post-LHC accelerator project at CERN by the time of the next Strategy update”. The FCC study has implemented the ESPP recommendation by developing a long-term vision for an “accelerator project in a global context”. This document describes the detailed design and preparation of a construction project for a post-LHC circular energy frontier collider “in collaboration with national institutes, laboratories and universities worldwide”, and enhanced by a strong participation of industrial partners. Now, a coordinated preparation effort can be based on a core of an ever-growing consortium of already more than 135 institutes worldwide. The technology for constructing a high-energy circular hadron collider can be brought to the technology readiness level required for constructing within the coming ten years through a focused R&D programme. The FCC-hh concept comprises in the baseline scenario a power-saving, low-temperature superconducting magnet system based on an evolution of the Nb3Sn technology pioneered at the HL-LHC, an energy-efficient cryogenic refrigeration infrastructure based on a neon-helium (Nelium) light gas mixture, a high-reliability and low loss cryogen distribution infrastructure based on Invar, high-power distributed beam transfer using superconducting elements and local magnet energy recovery and re-use technologies that are already gradually introduced at other CERN accelerators. On a longer timescale, high-temperature superconductors can be developed together with industrial partners to achieve an even more energy efficient particle collider or to reach even higher collision energies.The re-use of the LHC and its injector chain, which also serve for a concurrently running physics programme, is an essential lever to come to an overall sustainable research infrastructure at the energy frontier. Strategic R&D for FCC-hh aims at minimising construction cost and energy consumption, while maximising the socio-economic impact. It will mitigate technology-related risks and ensure that industry can benefit from an acceptable utility. Concerning the implementation, a preparatory phase of about eight years is both necessary and adequate to establish the project governance and organisation structures, to build the international machine and experiment consortia, to develop a territorial implantation plan in agreement with the host-states’ requirements, to optimise the disposal of land and underground volumes, and to prepare the civil engineering project. Such a large-scale, international fundamental research infrastructure, tightly involving industrial partners and providing training at all education levels, will be a strong motor of economic and societal development in all participating nations. The FCC study has implemented a set of actions towards a coherent vision for the world-wide high-energy and particle physics community, providing a collaborative framework for topically complementary and geographically well-balanced contributions. This conceptual design report lays the foundation for a subsequent infrastructure preparatory and technical design phase.

425 citations


Journal ArticleDOI
A. Abada1, Marcello Abbrescia2, Marcello Abbrescia3, Shehu S. AbdusSalam4  +1501 moreInstitutions (239)
TL;DR: In this article, the physics opportunities of the Future Circular Collider (FC) were reviewed, covering its e+e-, pp, ep and heavy ion programs, and the measurement capabilities of each FCC component, addressing the study of electroweak, Higgs and strong interactions.
Abstract: We review the physics opportunities of the Future Circular Collider, covering its e+e-, pp, ep and heavy ion programmes. We describe the measurement capabilities of each FCC component, addressing the study of electroweak, Higgs and strong interactions, the top quark and flavour, as well as phenomena beyond the Standard Model. We highlight the synergy and complementarity of the different colliders, which will contribute to a uniquely coherent and ambitious research programme, providing an unmatchable combination of precision and sensitivity to new physics.

407 citations


Journal ArticleDOI
TL;DR: In this article, a review of the recent advances in carbon-based polymer nanocomposites for electromagnetic interference (EMI) shielding is presented and related to structure and processing, focusing on the effects of nanoparticle aspect ratio and possible functionalization, dispersion and alignment during processing, as well as the use of nanohybrids and 3D reinforcements.

405 citations


Journal ArticleDOI
TL;DR: In this paper, the authors review the recent advances on the understanding of structural heterogeneities in metallic supercooled liquids and the influence of the structural heterogeneity on the overall mechanical properties of the corresponding amorphous alloys.

386 citations


Journal ArticleDOI
22 Feb 2019
TL;DR: In this paper, a review of the state-of-the-art in this field can be found, including non-Kerr nonlinearities, spin-orbit coupling and quantum fluctuations, among others.
Abstract: 2D and 3D solitons and related states, such as quantum droplets, can appear in optical systems, atomic Bose–Einstein condensates (BECs) and liquid crystals, among other physical settings. However, multidimensional solitary states supported by the standard cubic nonlinearity tend to be strongly unstable — a property far less present in 1D systems. Thus, the central challenge is to stabilize multidimensional states, and to that end numerous approaches have been proposed over the years. Most strategies involve non-cubic nonlinearities or using various potentials, including periodic ones. Completely new directions have recently emerged in two-component BECs with spin–orbit coupling, which have been predicted to support stable 2D and metastable 3D solitons. A recent breakthrough is the creation of 3D quantum droplets. These are self-sustained states existing in two-component BECs, stabilized by the quantum fluctuations around the underlying mean-field states. Here, we review recent results in this field and outline outstanding current challenges. Multidimensional self-trapped states exist in many models of physical systems. However, they are highly unstable in media with the universal cubic nonlinearity. We review different mechanisms that may stabilize them, including non-Kerr nonlinearities, spin–orbit coupling and quantum fluctuations, among others.

263 citations


Journal ArticleDOI
TL;DR: In this article, a survey of application layer communication protocols to fulfill the IoT communication requirements, and their potential for implementation in fog-and cloud-based IoT systems is presented, including request-reply and publish-subscribe protocols.
Abstract: The fast increment in the number of IoT (Internet of Things) devices is accelerating the research on new solutions to make cloud services scalable. In this context, the novel concept of fog computing as well as the combined fog-to-cloud computing paradigm is becoming essential to decentralize the cloud, while bringing the services closer to the end-system. This article surveys e application layer communication protocols to fulfill the IoT communication requirements, and their potential for implementation in fog- and cloud-based IoT systems. To this end, the article first briefly presents potential protocol candidates, including request-reply and publish-subscribe protocols. After that, the article surveys these protocols based on their main characteristics, as well as the main performance issues, including latency, energy consumption, and network throughput. These findings are thereafter used to place the protocols in each segment of the system (IoT, fog, cloud), and thus opens up the discussion on their choice, interoperability, and wider system integration. The survey is expected to be useful to system architects and protocol designers when choosing the communication protocols in an integrated IoT-to-fog-to-cloud system architecture.

256 citations


Proceedings ArticleDOI
06 Apr 2019
TL;DR: This article proposed an improved self-supervised method, where a single neural encoder is followed by multiple workers that jointly solve different selfsupervised tasks, and the needed consensus across different tasks naturally imposes meaningful constraints to the encoder, contributing to discover general representations and to minimize the risk of learning superficial ones.
Abstract: Learning good representations without supervision is still an open issue in machine learning, and is particularly challenging for speech signals, which are often characterized by long sequences with a complex hierarchical structure. Some recent works, however, have shown that it is possible to derive useful speech representations by employing a self-supervised encoder-discriminator approach. This paper proposes an improved self-supervised method, where a single neural encoder is followed by multiple workers that jointly solve different self-supervised tasks. The needed consensus across different tasks naturally imposes meaningful constraints to the encoder, contributing to discover general representations and to minimize the risk of learning superficial ones. Experiments show that the proposed approach can learn transferable, robust, and problem-agnostic features that carry on relevant information from the speech signal, such as speaker identity, phonemes, and even higher-level features such as emotional cues. In addition, a number of design choices make the encoder easily exportable, facilitating its direct usage or adaptation to different problems.

Proceedings ArticleDOI
15 Jun 2019
TL;DR: This work proposes a Recurrent network for multiple object Video Object Segmentation (RVOS) that is fully end-to-end trainable and achieves faster inference runtimes than previous methods, reaching 44ms/frame on a P100 GPU.
Abstract: Multiple object video object segmentation is a challenging task, specially for the zero-shot case, when no object mask is given at the initial frame and the model has to find the objects to be segmented along the sequence. In our work, we propose a Recurrent network for multiple object Video Object Segmentation (RVOS) that is fully end-to-end trainable. Our model incorporates recurrence on two different domains: (i) the spatial, which allows to discover the different object instances within a frame, and (ii) the temporal, which allows to keep the coherence of the segmented objects along time. We train RVOS for zero-shot video object segmentation and are the first ones to report quantitative results for DAVIS-2017 and YouTube-VOS benchmarks. Further, we adapt RVOS for one-shot video object segmentation by using the masks obtained in previous time steps as inputs to be processed by the recurrent module. Our model reaches comparable results to state-of-the-art techniques in YouTube-VOS benchmark and outperforms all previous video object segmentation methods not using online learning in the DAVIS-2017 benchmark. Moreover, our model achieves faster inference runtimes than previous methods, reaching 44ms/frame on a P100 GPU.

Journal ArticleDOI
TL;DR: There is a cluster of four methods that rank significantly better than the other methods, with one clear winner, and the inter-scanner robustness ranking shows that not all the methods generalize to unseen scanners.
Abstract: Quantification of cerebral white matter hyperintensities (WMH) of presumed vascular origin is of key importance in many neurological research studies. Currently, measurements are often still obtained from manual segmentations on brain MR images, which is a laborious procedure. The automatic WMH segmentation methods exist, but a standardized comparison of the performance of such methods is lacking. We organized a scientific challenge, in which developers could evaluate their methods on a standardized multi-center/-scanner image dataset, giving an objective comparison: the WMH Segmentation Challenge. Sixty T1 + FLAIR images from three MR scanners were released with the manual WMH segmentations for training. A test set of 110 images from five MR scanners was used for evaluation. The segmentation methods had to be containerized and submitted to the challenge organizers. Five evaluation metrics were used to rank the methods: 1) Dice similarity coefficient; 2) modified Hausdorff distance (95th percentile); 3) absolute log-transformed volume difference; 4) sensitivity for detecting individual lesions; and 5) F1-score for individual lesions. In addition, the methods were ranked on their inter-scanner robustness; 20 participants submitted their methods for evaluation. This paper provides a detailed analysis of the results. In brief, there is a cluster of four methods that rank significantly better than the other methods, with one clear winner. The inter-scanner robustness ranking shows that not all the methods generalize to unseen scanners. The challenge remains open for future submissions and provides a public platform for method evaluation.

Journal ArticleDOI
TL;DR: The Cequia of Manresa as discussed by the authors is a 26km open channel constructed in the fourteenth century that conveys water from the Llobregat River to the city of manresa using an elevation difference of 10.4
Abstract: The Cequia of Manresa is a 26-km open channel constructed in the fourteenth century that conveys water from the Llobregat River to the city of Manresa using an elevation difference of 10.4 ...

Journal ArticleDOI
A. Abada1, Marcello Abbrescia2, Marcello Abbrescia3, Shehu S. AbdusSalam4  +1496 moreInstitutions (238)
TL;DR: The third volume of the FCC Conceptual Design Report as discussed by the authors is devoted to the hadron collider FCC-hh, and summarizes the physics discovery opportunities, presents the FCC-HH accelerator design, performance reach, and staged operation plan, discusses the underlying technologies, the civil engineering and technical infrastructure, and also sketches a possible implementation.
Abstract: In response to the 2013 Update of the European Strategy for Particle Physics (EPPSU), the Future Circular Collider (FCC) study was launched as a world-wide international collaboration hosted by CERN. The FCC study covered an energy-frontier hadron collider (FCC-hh), a highest-luminosity high-energy lepton collider (FCC-ee), the corresponding 100 km tunnel infrastructure, as well as the physics opportunities of these two colliders, and a high-energy LHC, based on FCC-hh technology. This document constitutes the third volume of the FCC Conceptual Design Report, devoted to the hadron collider FCC-hh. It summarizes the FCC-hh physics discovery opportunities, presents the FCC-hh accelerator design, performance reach, and staged operation plan, discusses the underlying technologies, the civil engineering and technical infrastructure, and also sketches a possible implementation. Combining ingredients from the Large Hadron Collider (LHC), the high-luminosity LHC upgrade and adding novel technologies and approaches, the FCC-hh design aims at significantly extending the energy frontier to 100 TeV. Its unprecedented centre-of-mass collision energy will make the FCC-hh a unique instrument to explore physics beyond the Standard Model, offering great direct sensitivity to new physics and discoveries.

Journal ArticleDOI
TL;DR: The iSeg-2017 challenge provides a set of six-month infant subjects with manual labels for training and testing the participating methods, and among the 21 automatic segmentation methods participating, the eight top-ranked teams are reviewed, in terms of Dice ratio, modified Hausdorff distance, and average surface distance.
Abstract: Accurate segmentation of infant brain magnetic resonance (MR) images into white matter (WM), gray matter (GM), and cerebrospinal fluid is an indispensable foundation for early studying of brain growth patterns and morphological changes in neurodevelopmental disorders. Nevertheless, in the isointense phase (approximately 6–9 months of age), due to inherent myelination and maturation process, WM and GM exhibit similar levels of intensity in both T1-weighted and T2-weighted MR images, making tissue segmentation very challenging. Although many efforts were devoted to brain segmentation, only a few studies have focused on the segmentation of six-month infant brain images. With the idea of boosting methodological development in the community, iSeg-2017 challenge ( http://iseg2017.web.unc.edu ) provides a set of six-month infant subjects with manual labels for training and testing the participating methods. Among the 21 automatic segmentation methods participating in iSeg-2017, we review the eight top-ranked teams, in terms of Dice ratio, modified Hausdorff distance, and average surface distance, and introduce their pipelines, implementations, as well as source codes. We further discuss the limitations and possible future directions. We hope the dataset in iSeg-2017, and this paper could provide insights into methodological development for the community.

Journal ArticleDOI
TL;DR: This work reviews recent strategies of surface modification to simultaneously address implant biointegration while mitigating bacterial infections, and two emerging solutions are considered, multifunctional chemical coatings and nanotopographical features.
Abstract: In biomaterials science, it is nowadays well accepted that improving the biointegration of dental and orthopedic implants with surrounding tissues is a major goal. However, implant surfaces that support osteointegration may also favor colonization of bacterial cells. Infection of biomaterials and subsequent biofilm formation can have devastating effects and reduce patient quality of life, representing an emerging concern in healthcare. Conversely, efforts toward inhibiting bacterial colonization may impair biomaterial–tissue integration. Therefore, to improve the long-term success of medical implants, biomaterial surfaces should ideally discourage the attachment of bacteria without affecting eukaryotic cell functions. However, most current strategies seldom investigate a combined goal. This work reviews recent strategies of surface modification to simultaneously address implant biointegration while mitigating bacterial infections. To this end, two emerging solutions are considered, multifunctional chemical coatings and nanotopographical features.

Journal ArticleDOI
TL;DR: The United Nations General Assembly agreed and approved in September 2015 the document ‘2030 Agenda for sustainable development’, which contains a set of measures aiming to balance economic progres....
Abstract: The United Nations General Assembly agreed and approved in September 2015 the document ‘2030 Agenda for Sustainable Development’, which contains a set of measures aiming to balance economic progres...

Journal ArticleDOI
TL;DR: In this article, a 3D coupled thermo-mechanical model has been used to predict residual stresses and distortions in additive manufactured (AM) parts, and different preheating strategies have been also analyzed to check their effectiveness on the mitigation of both distortions and residual stresses.
Abstract: Residual stresses and distortion in Additive Manufactured (AM) parts are two key obstacles which seriously hinder the wide application of this technology. Nowadays, understanding the thermomechanical behavior induced by the AM process is still a complex task which must take into account the effects of both the process and the material parameters, the microstructure evolution as well as the pre-heating strategy. One of the challenges of this work is to increase the complexity of the geometries used to study the thermomechanical behavior induced by the AM process. The reference geometries are a rectangular and a S-shaped structures made of 44-layers each. The samples have been fabricated by Directed Energy Deposition (DED). In-situ thermal and distortion histories of the substrate are measured in order to calibrate the 3D coupled thermo-mechanical model. Once the numerical results showed a good agreement with the temperature measurements, the validated model has been used to predict the residual stresses and distortions. Different process parameters have been analyzed to study their sensitivity to the process assessment. Different preheating strategies have been also analyzed to check their effectiveness on the mitigation of both distortions and residual stresses. Finally, some simplifications of the actual scanning sequence are proposed to reduce the computational cost without loss of the accuracy of the simulation framework.

Journal ArticleDOI
TL;DR: The objective of this review is to concisely describe the relevance of hydrogel dressings as platforms for delivery of active molecules for improved management of difficult- to-treat wounds.
Abstract: Background Composed in a large extent of water and due to their nonadhesiveness, hydrogels found their way to the wound dressing market as materials that provide a moisture environment for healing while being comfortable to the patient Hydrogels' exploitation is constantly increasing after evidences of their even broader therapeutic potential due to resemblance to dermal tissue and ability to induce partial skin regeneration The innovation in advanced wound care is further directed to the development of so-called active dressings, where hydrogels are combined with components that enhance the primary purpose of providing a beneficial environment for wound healing Objective The objective of this review is to concisely describe the relevance of hydrogel dressings as platforms for delivery of active molecules for improved management of difficult- to-treat wounds The emphasis is on the most recent advances in development of stimuli- responsive hydrogels, which allow for control over wound healing efficiency in response to different external modalities Novel strategies for monitoring of the wound status and healing progress based on incorporation of sensor molecules into the hydrogel platforms are also discussed

Proceedings ArticleDOI
18 Apr 2019
TL;DR: The findings suggest that contextualized word embeddings are less biased than standard ones even when the latter are debiased.
Abstract: Gender bias is highly impacting natural language processing applications. Word embeddings have clearly been proven both to keep and amplify gender biases that are present in current data sources. Recently, contextualized word embeddings have enhanced previous word embedding techniques by computing word vector representations dependent on the sentence they appear in. In this paper, we study the impact of this conceptual change in the word embedding computation in relation with gender bias. Our analysis includes different measures previously applied in the literature to standard word embeddings. Our findings suggest that contextualized word embeddings are less biased than standard ones even when the latter are debiased.

Journal ArticleDOI
TL;DR: A review focusing on atmospheric pressure plasma jets as the most studied plasma devices in plasma medicine and compiles the conditions employed to generate reactive oxygen and nitrogen species (RONS) in relevant liquids and the concentration ranges obtained.
Abstract: Reactive oxygen and nitrogen species (RONS) are among the key factors in plasma medicine. They are generated by atmospheric plasmas in biological fluids, living tissues and in a variety of liquids. This ability of plasmas to create a delicate mix of RONS in liquids has been used to design remote or indirect treatments for oncological therapy by treating biological fluids by plasmas and putting them in contact with the tumour. Documented effects include selective cancer cell toxicity, even though the exact mechanisms involved are still under investigation. However, the “right” dose for suitable therapeutical activity is crucial and still under debate. The wide variety of plasma sources hampers comparisons. This review focuses on atmospheric pressure plasma jets as the most studied plasma devices in plasma medicine and compiles the conditions employed to generate RONS in relevant liquids and the concentration ranges obtained. The concentrations of H2O2, NO2−, NO3− and short-lived oxygen species are compared critically to provide a useful overview for the reader.

Journal ArticleDOI
TL;DR: Evaluated the microfibers' detachment rates of finished garments and provided a set of comparable units to report the results, finding that there was a high correlation between the MF detachment and the textile article superficial density.

Journal ArticleDOI
TL;DR: In this article, a relaxation of the Moore-Gibson-Thompson equation has been proposed for a thermo-elastic model where the heat conduction is described by a relaxation.
Abstract: We consider a thermoelastic theory where the heat conduction is described by the Moore–Gibson–Thompson equation. In fact, this equation can be obtained after the introduction of a relaxation parame...

Journal ArticleDOI
TL;DR: The role of the plasma membrane is reviewed, which involves sensors of membrane unfolding, membrane tension, membrane curvature or membrane domain rearrangement, and how this mechanical response to mechanical stimuli triggers downstream biochemical responses.
Abstract: Cells are constantly submitted to external mechanical stresses, which they must withstand and respond to. By forming a physical boundary between cells and their environment that is also a biochemical platform, the plasma membrane (PM) is a key interface mediating both cellular response to mechanical stimuli, and subsequent biochemical responses. Here, we review the role of the PM as a mechanosensing structure. We first analyse how the PM responds to mechanical stresses, and then discuss how this mechanical response triggers downstream biochemical responses. The molecular players involved in PM mechanochemical transduction include sensors of membrane unfolding, membrane tension, membrane curvature or membrane domain rearrangement. These sensors trigger signalling cascades fundamental both in healthy scenarios and in diseases such as cancer, which cells harness to maintain integrity, keep or restore homeostasis and adapt to their external environment. This article is part of a discussion meeting issue ‘Forc...

Proceedings ArticleDOI
15 Jun 2019
TL;DR: An inverse cooking system that recreates cooking recipes given food images by predicting ingredients as sets by means of a novel architecture, modeling their dependencies without imposing any order, and then generates cooking instructions by attending to both image and its inferred ingredients simultaneously.
Abstract: People enjoy food photography because they appreciate food. Behind each meal there is a story described in a complex recipe and, unfortunately, by simply looking at a food image we do not have access to its preparation process. Therefore, in this paper we introduce an inverse cooking system that recreates cooking recipes given food images. Our system predicts ingredients as sets by means of a novel architecture, modeling their dependencies without imposing any order, and then generates cooking instructions by attending to both image and its inferred ingredients simultaneously. We extensively evaluate the whole system on the large-scale Recipe1M dataset and show that (1) we improve performance w.r.t. previous baselines for ingredient prediction; (2) we are able to obtain high quality recipes by leveraging both image and ingredients; (3) our system is able to produce more compelling recipes than retrieval-based approaches according to human judgment. We make code and models publicly available.

Journal ArticleDOI
TL;DR: This work has developed a computationally efficient optimal control framework to predict human gaits based on optimization of a performance criterion without relying on experimental data, and identified a multi-objective performance criterion combining energy and effort considerations that produces physiologically realistic walking gaits.
Abstract: Physics-based predictive simulations of human movement have the potential to support personalized medicine, but large computational costs and difficulties to model control strategies have limited t...

Journal ArticleDOI
TL;DR: By subjecting suspended epithelial monolayers to stretch, it is found that they dissipate stresses on a minute timescale and that relaxation can be described by a power law with an exponential cut-off at timescales larger than about 10 s.
Abstract: Epithelial monolayers are one-cell-thick tissue sheets that line most of the body surfaces, separating internal and external environments. As part of their function, they must withstand extrinsic mechanical stresses applied at high strain rates. However, little is known about how monolayers respond to mechanical deformations. Here, by subjecting suspended epithelial monolayers to stretch, we find that they dissipate stresses on a minute timescale and that relaxation can be described by a power law with an exponential cut-off at timescales larger than about 10 s. This process involves an increase in monolayer length, pointing to active remodelling of cellular biopolymers at the molecular scale during relaxation. Strikingly, monolayers consisting of tens of thousands of cells relax stress with similar dynamics to single rounded cells, and both respond similarly to perturbations of the actomyosin cytoskeleton. By contrast, cell–cell junctional complexes and intermediate filaments do not relax tissue stress, but form stable connections between cells, allowing monolayers to behave rheologically as single cells. Taken together, our data show that actomyosin dynamics governs the rheological properties of epithelial monolayers, dissipating applied stresses and enabling changes in monolayer length. Stress relaxation in cell monolayers shows remarkable similarities with that of single cells, suggesting the rheology of epithelial tissues is mediated by the actomyosin cortex—with dynamics reminiscent of those on a cellular level.

Journal ArticleDOI
A. J. Cenarro1, Mariano Moles, David Cristóbal-Hornillos1, Antonio Marín-Franch1, Alessandro Ederoclite1, Jesús A. Varela1, Carlos López-Sanjuan1, C. Hernández-Monteagudo1, Raul E. Angulo, H. Vázquez Ramió, Kerttu Viironen1, S. Bonoli1, Alvaro Orsi, G. Hurier, I. San Roman, N. Greisel, G. Vilella-Rojo, L. A. Díaz-García, R. Logroño-García, Siddhartha Gurung-López, D. Spinoso, David Izquierdo-Villalba, J. A. L. Aguerri1, J. A. L. Aguerri2, C. Allende Prieto2, C. Allende Prieto1, C. Bonatto3, J. M. Carvano, Ana L. Chies-Santos3, Simone Daflon, R. A. Dupke4, R. A. Dupke5, Jesús Falcón-Barroso1, Jesús Falcón-Barroso2, Denise R. Gonçalves6, Y. Jimenez-Teja, Alberto Molino7, Vinicius M. Placco8, Enrique Solano1, Devin D. Whitten8, J. Abril, Jordi Anton, R. Bello, S. Bielsa de Toledo, J. Castillo-Ramirez, Sergio Chueca, T. Civera, M. C. Díaz-Martín, M. Dominguez-Martinez, J. Garzaran-Calderaro, J. Hernández-Fuertes, R. Iglesias-Marzoa, C. Íniguez, J. M. Jimenez Ruiz, K. Kruuse, J. L. Lamadrid, N. M. Lasso-Cabrera, G. López-Alegre, A. López-Sainz, N. Maicas, A. Moreno-Signes, D. Muniesa, S. Rodríguez-Llano, F. Rueda-Teruel, S. Rueda-Teruel, I. Soriano-Laguia, V. Tilve, L. Valdivielso, A. Yanes-Díaz, Jailson S. Alcaniz9, C. Mendes de Oliveira7, Laerte Sodré7, Paula Coelho7, R. Lopes de Oliveira, Antti Tamm10, H. S. Xavier7, Luis Raul Weber Abramo7, Stavros Akras, Emilio J. Alfaro1, Alvaro Alvarez-Candal, B. Ascaso, Michael A. Beasley1, Michael A. Beasley2, Timothy C. Beers8, M. Borges Fernandes, G. R. Bruzual11, M. L. Buzzo7, J. M. Carrasco12, J. Cepa2, J. Cepa1, Arianna Cortesi7, M. V. Costa-Duarte7, M. De Prá, Ginevra Favole, A. Galarza, Lluís Galbany13, K. Garcia6, R. M. González Delgado1, José Ignacio González-Serrano1, L. A. Gutiérrez-Soto6, J. A. Hernandez-Jimenez7, Antonio Kanaan, Hanindyo Kuncarayakti14, Ricardo G. Landim7, J. Laur10, Javier Licandro2, Javier Licandro1, G. B. Lima Neto7, J. D. Lyman15, J. Maíz Apellániz1, Jordi Miralda-Escudé12, Jordi Miralda-Escudé16, D. Morate1, J. P. Nogueira-Cavalcante, P. M. Novais7, M. Oncins12, Ivan Oteo17, Ivan Oteo18, Roderik Overzier, C. B. Pereira, Alberto Rebassa-Mansergas19, Ribamar R. R. Reis6, Fernando Roig, M. Sako20, N. Salvador-Rusinol2, N. Salvador-Rusinol1, L. Sampedro7, Patricia Sanchez-Blazquez21, W. A. Santos7, Linda Schmidtobreick18, Beatriz B. Siffert6, Eduardo Telles, José M. Vílchez1 
TL;DR: The Javalambre Photometric Local Universe Survey (J-PLUS) as mentioned in this paper is an ongoing 12-band photometric optical survey, observing thousands of square degrees of the Northern Hemisphere from the dedicated JAST/T80 telescope at the OAS.
Abstract: The Javalambre Photometric Local Universe Survey (J-PLUS) is an ongoing 12-band photometric optical survey, observing thousands of square degrees of the Northern Hemisphere from the dedicated JAST/T80 telescope at the Observatorio Astrofisico de Javalambre (OAJ). The T80Cam is a camera with a field of view of 2 deg 2 mounted on a telescope with a diameter of 83 cm, and is equipped with a unique system of filters spanning the entire optical range (3500-10 000 A). This filter system is a combination of broad-, medium-, and narrow-band filters, optimally designed to extract the rest-frame spectral features (the 3700-4000 A Balmer break region, Hδ, Ca H+K, the G band, and the Mg b and Ca triplets) that are key to characterizing stellar types and delivering a low-resolution photospectrum for each pixel of the observed sky. With a typical depth of AB ∼21.25 mag per band, this filter set thus allows for an unbiased and accurate characterization of the stellar population in our Galaxy, it provides an unprecedented 2D photospectral information for all resolved galaxies in the local Universe, as well as accurate photo-z estimates (at the δ z/(1 + z)∼0.005-0.03 precision level) for moderately bright (up to r∼20 mag) extragalactic sources. While some narrow-band filters are designed for the study of particular emission features ([O II]/λ3727, Hα/λ6563) up to z< 0.017, they also provide well-defined windows for the analysis of other emission lines at higher redshifts. As a result, J-PLUS has the potential to contribute to a wide range of fields in Astrophysics, both in the nearby Universe (Milky Way structure, globular clusters, 2D IFU-like studies, stellar populations of nearby and moderate-redshift galaxies, clusters of galaxies) and at high redshifts (emission-line galaxies at z≈0.77, 2.2, and 4.4, quasi-stellar objects, etc.). With this paper, we release the first ∼1000 deg 2 of J-PLUS data, containing about 4.3 million stars and 3.0 million galaxies at r< 21 mag. With a goal of 8500 deg 2 for the total J-PLUS footprint, these numbers are expected to rise to about 35 million stars and 24 million galaxies by the end of the survey.

Journal ArticleDOI
TL;DR: This paper presents a novel step-up dc to ac converter with only one power supply that has the ability of self-voltage balancing and does not apply end side H-bridge to produce a bipolar staircase waveform.
Abstract: This paper presents a novel step-up dc to ac converter with only one power supply. These types of converters are suitable for renewable and sustainable energy applications with low input dc sources. The proposed topology has the ability of self-voltage balancing and does not apply end side H-bridge to produce a bipolar staircase waveform. Consequently, switching losses and voltage stress of semiconductor components are reduced to a great extent. A small dc voltage source can be used to achieve a high voltage high quality ac waveform through switching the precharged capacitors in series and in parallel. Circuit configuration and its operation principle, capacitors’ charging process, thermal model, capacitances, and losses calculations are discussed in details. Moreover, the comparison of the proposed circuit with the other single source multilevel converters shows that the proposed topology reduces the number of circuit elements. Finally, a laboratory nine-level prototype is built to verify the theoretical analyses and feasibility of the proposed topology. The experimental results show that the converter efficiency at 1 KW output power is 92.75%.