Tokyo Institute of Technology

About: Tokyo Institute of Technology is a education organization based out in Tokyo, Tôkyô, Japan. It is known for research contribution in the topics: Catalysis & Thin film. The organization has 46775 authors who have published 101656 publications receiving 2357893 citations. The organization is also known as: Tokyo Tech & Tokodai.

Multiple Label-Free Detection of Antigen−Antibody Reaction Using Localized Surface Plasmon Resonance-Based Core−Shell Structured Nanoparticle Layer Nanochip

Abstract: In this research, a localized surface plasmon resonance (LSPR)-based bioanalysis method for developing multiarray optical nanochip suitable for screening bimolecular interactions is described. LSPR-based label-free monitoring enables to solve the problems of conventional methods that require large sample volumes and time-consuming labeling procedures. We developed a multiarray LSPR-based nanochip for the label-free detection of proteins. The multiarray format was constructed by a core-shell-structured nanoparticle layer, which provided 300 nanospots on the sensing surface. Antibodies were immobilized onto the nanospots using their interaction with Protein A. The concentrations of antigens were determined from the peak absorption intensity of the LSPR spectra. We demonstrated the capability of the array measurement using immunoglobulins (IgA, IgD, IgG, IgM), C-reactive protein, and fibrinogen. The detection limit of our label-free method was 100 pg/mL. Our nanochip is readily transferable to monitor the interactions of other biomolecules, such as whole cells or receptors, with a massively parallel detection capability in a highly miniaturized package. We anticipate that the direct label-free optical immunoassay of proteins reported here will revolutionize clinical diagnosis and accelerate the development of hand-held and user-friendly point-of-care devices.

Strong convergence theorem for a generalized equilibrium problem and a nonexpansive mapping in a Hilbert space

Abstract: We introduce an iterative method for finding a common element of the set of solutions of a generalized equilibrium problem and the set of fixed points of a nonexpansive mapping in a Hilbert space and then obtain that the sequence converges strongly to a common element of two sets. Using this result, we prove three new strong convergence theorems in fixed point problems, variational inequalities and equilibrium problems.

Development and characterization of Ni-free Ti-base shape memory and superelastic alloys

Abstract: Recently the Ni-hypersensitivity and toxicity of Ni have stimulated the development of Ni-free shape memory alloys. The β-Ti alloys are the most attractive candidates for biomedical shape memory alloys. Ti–Nb–X (X = Zr, Ta, Mo, Au, Pd, Pt, Al, Ga, Ge, O) and Ti–Mo–X (X = Ta, Nb, Zr, Au, Pd, Pt, Al, Ga, Ge) alloys have been developed and their shape memory effect and superelasticity were investigated systematically by the present authors for about 5 years. Although shape memory effect and superelasticity observed in the Ti–Nb alloys, the low critical stress for slip deformation caused the superelasticity not to reveal a large strain at room temperature. However, low temperature annealing and an aging treatment were effective in improving superelasticity. Additions of alloying elements such as Zr, Ta, Mo, Au, Pt and Al were also effective in stabilizing the superelasticity. In this paper, the basic characteristics of Ti–Nb, Ti–Nb–Zr, Ti–Nb–Ta and Ti–Nb–O are to be briefly reviewed based on the recent works of the present authors.

Approximation of common fixed points of a countable family of nonexpansive mappings in a Banach space

Abstract: In this paper, to find a common fixed point of a family of nonexpansive mappings, we introduce a Halpern type iterative sequence. Then we prove that such a sequence converges strongly to a common fixed point of nonexpansive mappings. Moreover, we apply our result to the problem of finding a common fixed point of a countable family of nonexpansive mappings and the problem of finding a zero of an accretive operator.