Tokyo University of Science

About: Tokyo University of Science is a education organization based out in Tokyo, Japan. It is known for research contribution in the topics: Catalysis & Thin film. The organization has 15800 authors who have published 24147 publications receiving 438081 citations. The organization is also known as: Tōkyō Rika Daigaku & Science University of Tokyo.

IL-17-producing γδ T cells enhance bone regeneration

Abstract: Immune responses are crucial not only for host defence against pathogens but also for tissue maintenance and repair after injury. Lymphocytes are involved in the healing process after tissue injury, including bone fracture and muscle damage. However, the specific immune cell subsets and mediators of healing are not entirely clear. Here we show that γδ T cells produce IL-17A, which promotes bone formation and facilitates bone fracture healing. Repair is impaired in IL-17A-deficient mice due to a defect in osteoblastic bone formation. IL-17A accelerates bone formation by stimulating the proliferation and osteoblastic differentiation of mesenchymal progenitor cells. This study identifies a novel role for IL-17-producing γδ T cells in skeletal tissue regeneration.

Silver Nanoparticle Decorated Reduced Graphene Oxide (rGO) Nanosheet: A Platform for SERS Based Low-Level Detection of Uranyl Ion

Abstract: Herein, a simple wet-chemical pathway has been demonstrated for the synthesis of silver nanoparticle conjugated reduced graphene oxide nanosheets where dimethylformamide (DMF) is judiciously employed as an efficient reducing agent. Altogether, DMF reduces both silver nitrate (AgNO3) and graphene oxide (GO) in the reaction mixture. Additionally, the presence of polyvinylpyrolidone (PVP) assists the nanophasic growth and homogeneous distribution of the plasmonic nanoparticle Ag(0). Reduction of graphene oxide and the presence of aggregated Ag NPs on reduced graphene oxide (rGO) nanosheets are confirmed from various spectroscopic techniques. Finally, the composite material has been exploited as an intriguing platform for surface enhanced Raman scattering (SERS) based selective detection of uranyl (UO22+) ion. The limit of detection has been achieved to be as low as 10 nM. Here the normal Raman spectral (NRS) band of uranyl acetate (UAc) at 838 cm–1 shifts to 714 and 730 cm–1 as SERS bands for pH 5.0 and 12.0...

Bose-Condensed Gases at Finite Temperatures

Abstract: The discovery of Bose–Einstein condensation (BEC) in trapped ultracold atomic gases in 1995 has led to an explosion of theoretical and experimental research on the properties of Bose-condensed dilute gases. The first treatment of BEC at finite temperatures, this book presents a thorough account of the theory of two-component dynamics and nonequilibrium behaviour in superfluid Bose gases. It uses a simplified microscopic model to give a clear, explicit account of collective modes in both the collisionless and collision-dominated regions. Major topics such as kinetic equations, local equilibrium and two-fluid hydrodynamics are introduced at an elementary level. Explicit predictions are worked out and linked to experiments. Providing a platform for future experimental and theoretical studies on the finite temperature dynamics of trapped Bose gases, this book is ideal for researchers and graduate students in ultracold atom physics, atomic, molecular and optical physics and condensed matter physics.

In-vitro derived germinal centre B cells differentially generate memory B or plasma cells in vivo

Abstract: In response to T cell-dependent antigens, B cells proliferate extensively to form germinal centres (GC), and then differentiate into memory B (B(mem)) cells or long-lived plasma cells (LLPCs) by largely unknown mechanisms. Here we show a new culture system in which mouse naive B cells undergo massive expansion and isotype switching, and generate GC-phenotype B (iGB) cells. The iGB cells expressing IgG1 or IgM/D, but not IgE, differentiate into B(mem) cells in vivo after adoptive transfer and can elicit rapid immune responses with the help of cognate T cells. Secondary culture with IL-21 maintains the proliferation of the iGB cells, while shifting their in vivo developmental fate from B(mem) cells to LLPCs, an outcome that can be reversed by withdrawal of IL-21 in tertiary cultures. Thus, this system enables in vitro manipulation of B-cell fate, into either B(mem) cells or LLPCs, and will facilitate dissection of GC-B cell differentiation programs.