Institution
University of Notre Dame
Education•Notre Dame, Indiana, United States•
About: University of Notre Dame is a education organization based out in Notre Dame, Indiana, United States. It is known for research contribution in the topics: Population & Context (language use). The organization has 22238 authors who have published 55201 publications receiving 2032925 citations. The organization is also known as: University of Notre Dame du Lac & University of Notre Dame, South Bend.
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30 Jul 2014
409 citations
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TL;DR: This work has shown that the three-component supermolecule in the ternary cocrystal of 3,5-dinitrobenzoic acid, isonicotinamide, and 4-(dimethylamino)benzosic acid assembles through a "primary" and "secondary" hydrogen-bonding interaction between the stronger acid and pyridine.
Abstract: Getting the right balance between intermolecular interactions is crucial for the synthesis of supermolecules in a preconceived manner. The three-component supermolecule in the ternary cocrystal of 3,5-dinitrobenzoic acid, isonicotinamide, and 4-(dimethylamino)benzoic acid (1:1:1) assembles through a "primary" (between the stronger acid and pyridine) and a "secondary" hydrogen-bonding interaction (between the weaker acid and amide).
409 citations
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TL;DR: These are the first results to establish a significant role for dectin-1, in cooperation with TLR2, to activate a macrophage's proinflammatory response to a mycobacterial infection.
409 citations
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TL;DR: By coating the nanostructures with high-kappa dielectrics, scattering from Coulombic impurities can be strongly damped, and the resulting improvement in mobilities of carriers can be as much as an order of magnitude for thin 2D semiconductor membranes, and more for semiconductor nanowires.
Abstract: We propose a technique for achieving large improvements in carrier mobilities in 2- and 1-dimensional semiconductor nanostructures by modifying their dielectric environments. We show that by coating the nanostructures with high-kappa dielectrics, scattering from Coulombic impurities can be strongly damped. Though screening is also weakened, the damping of Coulombic scattering is much larger, and the resulting improvement in mobilities of carriers can be as much as an order of magnitude for thin 2D semiconductor membranes, and more for semiconductor nanowires.
409 citations
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TL;DR: This work identifies four key issues that present challenges to understanding and classifying mental disorder and discusses how the three systems’ approaches to these key issues correspond or diverge as a result of their different histories, purposes, and constituencies.
Abstract: The diagnosis of mental disorder initially appears relatively straightforward: Patients present with symptoms or visible signs of illness; health professionals make diagnoses based primarily on these symptoms and signs; and they prescribe medication, psychotherapy, or both, accordingly. However, despite a dramatic expansion of knowledge about mental disorders during the past half century, understanding of their components and processes remains rudimentary. We provide histories and descriptions of three systems with different purposes relevant to understanding and classifying mental disorder. Two major diagnostic manuals-the International Classification of Diseases and the Diagnostic and Statistical Manual of Mental Disorders-provide classification systems relevant to public health, clinical diagnosis, service provision, and specific research applications, the former internationally and the latter primarily for the United States. In contrast, the National Institute of Mental Health's Research Domain Criteria provides a framework that emphasizes integration of basic behavioral and neuroscience research to deepen the understanding of mental disorder. We identify four key issues that present challenges to understanding and classifying mental disorder: etiology, including the multiple causality of mental disorder; whether the relevant phenomena are discrete categories or dimensions; thresholds, which set the boundaries between disorder and nondisorder; and comorbidity, the fact that individuals with mental illness often meet diagnostic requirements for multiple conditions. We discuss how the three systems' approaches to these key issues correspond or diverge as a result of their different histories, purposes, and constituencies. Although the systems have varying degrees of overlap and distinguishing features, they share the goal of reducing the burden of suffering due to mental disorder.
408 citations
Authors
Showing all 22586 results
Name | H-index | Papers | Citations |
---|---|---|---|
George Davey Smith | 224 | 2540 | 248373 |
David Miller | 203 | 2573 | 204840 |
Patrick O. Brown | 183 | 755 | 200985 |
Dorret I. Boomsma | 176 | 1507 | 136353 |
Chad A. Mirkin | 164 | 1078 | 134254 |
Darien Wood | 160 | 2174 | 136596 |
Wei Li | 158 | 1855 | 124748 |
Timothy C. Beers | 156 | 934 | 102581 |
Todd Adams | 154 | 1866 | 143110 |
Albert-László Barabási | 152 | 438 | 200119 |
T. J. Pearson | 150 | 895 | 126533 |
Amartya Sen | 149 | 689 | 141907 |
Christopher Hill | 144 | 1562 | 128098 |
Tim Adye | 143 | 1898 | 109010 |
Teruki Kamon | 142 | 2034 | 115633 |