Institution
University of Notre Dame
Education•Notre Dame, Indiana, United States•
About: University of Notre Dame is a education organization based out in Notre Dame, Indiana, United States. It is known for research contribution in the topics: Population & Context (language use). The organization has 22238 authors who have published 55201 publications receiving 2032925 citations. The organization is also known as: University of Notre Dame du Lac & University of Notre Dame, South Bend.
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TL;DR: The atmospheric neutrino flux is measured using a 3.4-kt yr exposure of the IMB-3 detector and it is found that nonshowering events comprise 40% of the total and the fraction expected is (51{plus minus}5(syst)%).
Abstract: The atmospheric neutrino flux is measured using a 3.4-kt yr exposure of the IMB-3 detector. Single-ring events are classified as showering or nonshowering using the geometry of the \ifmmode \check{C}\else \v{C}\fi{}erenkov pattern. A simulation of neutrino interactions and three models of atmospheric neutrino production are used to predict the composition of the sample. Showering-nonshowering character is strongly correlated with the flavor of the neutrino parent. In the lepton momentum range p1500 MeV/c, we find that nonshowering events comprise [41\ifmmode\pm\else\textpm\fi{}3\ifmmode\pm\else\textpm\fi{}2syst]% of the total. The fraction expected is [51\ifmmode\pm\else\textpm\fi{}5(syst)]%.
309 citations
TL;DR: In this paper, male accessory glands were implanted in virgin females of Aedes aegypti to prevent insemination in 12 species, including Aedes, Anopheles, and Culex; interspecific transplant gave partial protection.
Abstract: Male accessory glands were implanted in virgin females of Aedes aegypti. When exposed to males, females copulated readily but were not inseminated; they remained sterile for life. Extract from one male could sterilize more than 64 females. The active principle may be a protein or peptide. Intraspecific transplant prevented insemination in 12 species, including Aedes, Anopheles, and Culex; interspecific transplant gave partial protection.
309 citations
309 citations
TL;DR: A new and improved way to predict immunoprotective cancer neoepitopes based in part on the difference in MHC-binding scores between the mutant epitope and its wild-type counterpart is defined.
Abstract: The mutational repertoire of cancers creates the neoepitopes that make cancers immunogenic. Here, we introduce two novel tools that identify, with relatively high accuracy, the small proportion of neoepitopes (among the hundreds of potential neoepitopes) that protect the host through an antitumor T cell response. The two tools consist of (a) the numerical difference in NetMHC scores between the mutated sequences and their unmutated counterparts, termed the differential agretopic index, and (b) the conformational stability of the MHC I–peptide interaction. Mechanistically, these tools identify neoepitopes that are mutated to create new anchor residues for MHC binding, and render the overall peptide more rigid. Surprisingly, the protective neoepitopes identified here elicit CD8-dependent immunity, even though their affinity for Kd is orders of magnitude lower than the 500-nM threshold considered reasonable for such interactions. These results greatly expand the universe of target cancer antigens and identify new tools for human cancer immunotherapy.
309 citations
University of Minnesota1, Stony Brook University2, University of Notre Dame3, Macquarie University4, University of North Texas5, University at Buffalo6, University of Kentucky7, University of Vermont8, University of Toronto9, University of South Florida10, University of Maryland, Baltimore11, Southern Methodist University12, University of Hawaii13, College of William & Mary14, Ghent University15, University of Utah16, University of Michigan17, Columbia University18, University of Kansas19, Pennsylvania State University20, University of California, Davis21, Georgia State University22, University of Iowa23, University of Georgia24, Texas A&M University25, Oklahoma State University–Stillwater26, University of Groningen27, University of Liverpool28, Florida State University29, Uniformed Services University of the Health Sciences30, Maastricht University31, Bryn Mawr College32, Purdue University33, University of Otago34, University of Maryland, College Park35, University of Arizona36, University of New South Wales37, Northwestern University38, Emory University39, Oak Ridge National Laboratory40, University of Pittsburgh41, Vanderbilt University42
TL;DR: The aims and current foci of the HiTOP Consortium, a group of 70 investigators working together to study empirical classification of psychopathology, are described, which pertain to continued research on the empirical organization of psychopathological constructs; the connection between personality and psychopathology; the utility of empirically based psychopathology constructs in both research and the clinic.
308 citations
Authors
Showing all 22586 results
| Name | H-index | Papers | Citations |
|---|---|---|---|
| George Davey Smith | 224 | 2540 | 248373 |
| David Miller | 203 | 2573 | 204840 |
| Patrick O. Brown | 183 | 755 | 200985 |
| Dorret I. Boomsma | 176 | 1507 | 136353 |
| Chad A. Mirkin | 164 | 1078 | 134254 |
| Darien Wood | 160 | 2174 | 136596 |
| Wei Li | 158 | 1855 | 124748 |
| Timothy C. Beers | 156 | 934 | 102581 |
| Todd Adams | 154 | 1866 | 143110 |
| Albert-László Barabási | 152 | 438 | 200119 |
| T. J. Pearson | 150 | 895 | 126533 |
| Amartya Sen | 149 | 689 | 141907 |
| Christopher Hill | 144 | 1562 | 128098 |
| Tim Adye | 143 | 1898 | 109010 |
| Teruki Kamon | 142 | 2034 | 115633 |