Institution
University of Notre Dame
Education•Notre Dame, Indiana, United States•
About: University of Notre Dame is a education organization based out in Notre Dame, Indiana, United States. It is known for research contribution in the topics: Population & Context (language use). The organization has 22238 authors who have published 55201 publications receiving 2032925 citations. The organization is also known as: University of Notre Dame du Lac & University of Notre Dame, South Bend.
Papers published on a yearly basis
Papers
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Ohio State University1, University of Notre Dame2, University of Warsaw3, Tel Aviv University4, Lawrence Livermore National Laboratory5, Princeton University6, University of Concepción7, University of Cambridge8, Chungbuk National University9, Korea Astronomy and Space Science Institute10, Nagoya University11, Massey University12, University of Auckland13, University of Canterbury14, Victoria University of Wellington15, Konan University16, University of Manchester17, Vaughn College of Aeronautics and Technology18, University of Exeter19, Centre national de la recherche scientifique20, Liverpool John Moores University21, University of St Andrews22, University of Tasmania23, Paul Sabatier University24, Dartmouth College25, University of Oxford26
TL;DR: Two planets with masses that could not have been detected with other techniques are identified; their discovery from only six confirmed microlensing planet detections suggests that solar system analogs may be common.
Abstract: Searches for extrasolar planets have uncovered an astonishing diversity of planetary systems, yet the frequency of solar system analogs remains unknown. The gravitational microlensing planet search method is potentially sensitive to multiple-planet systems containing analogs of all the solar system planets except Mercury. We report the detection of a multiple-planet system with microlensing. We identify two planets with masses of ∼0.71 and ∼0.27 times the mass of Jupiter and orbital separations of ∼2.3 and ∼4.6 astronomical units orbiting a primary star of mass ∼0.50 solar mass at a distance of ∼1.5 kiloparsecs. This system resembles a scaled version of our solar system in that the mass ratio, separation ratio, and equilibrium temperatures of the planets are similar to those of Jupiter and Saturn. These planets could not have been detected with other techniques; their discovery from only six confirmed microlensing planet detections suggests that solar system analogs may be common.
341 citations
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TL;DR: In this article, a deep neural network (DNN) is used to enforce the initial and boundary conditions, and the governing partial differential equations (i.e., Navier-Stokes equations) are incorporated into the loss of the DNN to drive the training.
341 citations
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University of Oregon1, University of Maryland Center for Environmental Science2, University of California, Los Angeles3, University of Illinois at Urbana–Champaign4, University of Cambridge5, University of Montana6, Institut national de la recherche agronomique7, University of Bordeaux8, Australian Museum9, University of California, Merced10, Ohio State University11, Laval University12, University of Southampton13, Oeschger Centre for Climate Change Research14, United States Forest Service15, Kyung Hee University16, Lanzhou University17, National Institute for Mathematical and Biological Synthesis18, Landcare Research19, University of Adelaide20, Ohio University21, University of Notre Dame22, University of Wisconsin-Madison23
TL;DR: A critical research need is to better integrate and reconcile the three major lines of evidence used to infer the existence of past refugia - fossil records, species distribution models and phylogeographic surveys - in order to characterize the complex spatiotemporal trajectories of species and populations in and out ofRefugia.
Abstract: Climate refugia, locations where taxa survive periods of regionally adverse climate, are thought to be critical for maintaining biodiversity through the glacial–interglacial climate changes of the Quaternary. A critical research need is to better integrate and reconcile the three major lines of evidence used to infer the existence of past refugia – fossil records, species distribution models and phylogeographic surveys – in order to characterize the complex spatiotemporal trajectories of species and populations in and out of refugia. Here we review the complementary strengths, limitations and new advances for these three approaches. We provide case studies to illustrate their combined application, and point the way towards new opportunities for synthesizing these disparate lines of evidence. Case studies with European beech, Qinghai spruce and Douglas-fir illustrate how the combination of these three approaches successfully resolves complex species histories not attainable from any one approach. Promising new statistical techniques can capitalize on the strengths of each method and provide a robust quantitative reconstruction of species history. Studying past refugia can help identify contemporary refugia and clarify their conservation significance, in particular by elucidating the fine-scale processes and the particular geographic locations that buffer species against rapidly changing climate.
340 citations
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TL;DR: In this paper, the authors provide an introduction to the Secularization debate as it presents itself at the end of the 1990s, focusing on the empirical and historical elements that undergird both the claims of secularization theory and those of its principal critics.
Abstract: This essay provides an introduction to the secularization debate as it presents itself at the end of the 1990s. After a conceptual survey from the mid-1960s to the present, we focus on the empirical and historical elements that undergird both the claims of secularization theory and those of its principal critics. Secularization theory is placed in relationship both to the Religion of Reason of the Enlightenment and developments in European religious historiography during the nineteenth century. The underlying conflict to be resolved with respect to secularization is whether the term can be used in a relatively value-neutral analytic way or whether it inherently carries unsubstantiated value presuppositions
339 citations
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TL;DR: It is shown that by regulating the transcription of these molecules, the synergistic activity of adipocyte-derived factors can potentiate MCF-7 cell proliferation and the full complement of adipokines shows an unparalleled ability to promote increased cell motility, migration, and the capacity for angiogenesis.
Abstract: Mammary epithelial cells are embedded in a unique extracellular environment to which adipocytes and other stromal cells contribute. Mammary epithelial cells are critically dependent on this milieu for survival. However, it remains unknown which adipocyte-secreted factors are required for the survival of the mammary epithelia and what role these adipokines play in the process of ductal carcinoma tumorigenesis. Here, we take a systematic molecular approach to investigate the multiple ways adipocytes and adipokines can uniquely influence the characteristics and phenotypic behavior of malignant breast ductal epithelial cells. Microarray analysis and luciferase reporter assays indicate that adipokines specifically induce several transcriptional programs involved in promoting tumorigenesis, including increased cell proliferation (IGF2, FOS, JUN, cyclin D1), invasive potential (MMP1, ATF3), survival (A20, NFkappaB), and angiogenesis. One of the key changes in the transformed ductal epithelial cells associated with the cell cycle involves the induction of NFkappaB (five-fold) and cyclin D1 (three-fold). We show that by regulating the transcription of these molecules, the synergistic activity of adipocyte-derived factors can potentiate MCF-7 cell proliferation. Furthermore, compared to other stromal cell-secreted factors, the full complement of adipokines shows an unparalleled ability to promote increased cell motility, migration, and the capacity for angiogenesis. Adipocyte-secreted factors can affect tumorigenesis by increasing the stabilization of pro-oncogenic factors such as beta-catenin and CDK6 as a result of a reduction in the gene expression of their inhibitors (i.e. p18). An in vivo coinjection system using 3T3-L1 adipocytes and SUM159PT cells effectively recapitulates the host-tumor interactions in primary tumors. Type VI collagen, a soluble extracellular matrix protein abundantly expressed in adipocytes, is further upregulated in adipocytes during tumorigenesis. It promotes GSK3beta phosphorylation, beta-catenin stabilization, and increased beta-catenin activity in breast cancer cells and may critically contribute towards tumorigenesis when not counterbalanced by other factors.
339 citations
Authors
Showing all 22586 results
Name | H-index | Papers | Citations |
---|---|---|---|
George Davey Smith | 224 | 2540 | 248373 |
David Miller | 203 | 2573 | 204840 |
Patrick O. Brown | 183 | 755 | 200985 |
Dorret I. Boomsma | 176 | 1507 | 136353 |
Chad A. Mirkin | 164 | 1078 | 134254 |
Darien Wood | 160 | 2174 | 136596 |
Wei Li | 158 | 1855 | 124748 |
Timothy C. Beers | 156 | 934 | 102581 |
Todd Adams | 154 | 1866 | 143110 |
Albert-László Barabási | 152 | 438 | 200119 |
T. J. Pearson | 150 | 895 | 126533 |
Amartya Sen | 149 | 689 | 141907 |
Christopher Hill | 144 | 1562 | 128098 |
Tim Adye | 143 | 1898 | 109010 |
Teruki Kamon | 142 | 2034 | 115633 |