Wichita State University

About: Wichita State University is a education organization based out in Wichita, Kansas, United States. It is known for research contribution in the topics: Population & Poison control. The organization has 4988 authors who have published 9563 publications receiving 253824 citations. The organization is also known as: WSU & Fairmount College.

Inhibition of human leukocyte elastase by derivatives of N-hydroxysuccinimide. A structure-activity-relationship study.

Abstract: A series of compounds derived from 3-alkyl-N-hydroxysuccinimide have been synthesized and their inhibitory activity toward human leukocyte elastase has been investigated. Compounds having an isobutyl or isopropyl group at the C-3 position have been found to be particularly effective inactivators of the enzyme. The introduction of a trans-styryl group (as in compounds 16 and 18) results in a drastic enhancement in inhibitory activity indicative of a favorable interaction between the phenyl ring and the S2' subsite of the enzyme. The compounds were found to be highly stable in buffer solution with no apparent change in structural integrity after 17 h (the period of observation). Studies with model compounds and high-field NMR indicate that these compounds function as mechanism-based inhibitors of the enzyme. Porcine pancreatic elastase is not inhibited by these compounds, while chymotrypsin and human leukocyte cathepsin G are also efficiently inactivated.

Multi-Objective Computation Sharing in Energy and Delay Constrained Mobile Edge Computing Environments

Abstract: In a mobile edge computing (MEC) network, mobile devices, also called edge clients, offload their computations to multiple edge servers that provide additional computing resources. Since the edge servers are placed at the network edge, e.g., cell-phone towers, transmission delays between edge servers and edge clients are shorter compared to those of cloud computing. In addition, edge clients can offload their tasks to other nearby edge clients with available computing resources by exploiting the Fog Computing (FC) paradigm. A major challenge in MEC and FC networks is to assign the tasks from edge clients to edge servers, as well as to other edge clients, in such a way that their tasks are completed with minimum energy consumption and minimum processing delay. In this paper, we model task offloading in MEC as a constrained multi-objective optimization problem (CMOP) that minimizes both the energy consumption and task processing delay of the mobile devices. To solve the CMOP, we design an evolutionary algorithm that can efficiently find a representative sample of the best trade-offs between energy consumption and task processing delay, i.e., the Pareto-optimal front. Compared to existing approaches for task offloading in MEC, we see that our approach finds offloading decisions with lower energy consumption and task processing delay.

Lane keeping under cognitive load: Performance changes and mechanisms

Abstract: OBJECTIVE: A pair of simulated driving experiments studied the effects of cognitive load on drivers' lane-keeping performance. BACKGROUND: Cognitive load while driving often reduces the variability of lane position. However, there is no agreement as to whether this effect should be interpreted as a performance loss, consistent with other effects of distraction on driving, or as an anomalous performance gain. METHOD: Participants in a high-fidelity driving simulator performed a lane-keeping task in lateral wind,with instructions to keep a steady lane position. Under high load conditions, participants performed a concurrent working memory task with auditory stimuli. Cross-spectral analysis measured the relationship between wind force and steering inputs. RESULTS: Cognitive load reduced the variability of lane position and increased the coupling between steering wheel position and crosswind strength. CONCLUSION: Although cognitive load disrupts driver performance in a variety of ways, it produces a performance gain in lane keeping.This effect appears to reflect drivers' efforts to protect lateral control against the risk of distraction, at the apparent neglect of other elements of driving performance. APPLICATION: Results may inform educational efforts to help drivers understand the risks of distraction and the inadequacies of compensatory driving strategies. Keywords: Driver distraction; Language: en

Building Blocks of Eumelanin: Relative Stability and Excitation Energies of Tautomers of 5,6-Dihydroxyindole and 5,6-Indolequinone

Abstract: Computation methods were used to examine the tautomerization equilibria for 5,6-dihydroxyindole (DHI, 2) and 5,6-indolequinone (IQ, 3). Relative energies were calculated at the B3LYP and PBE0 level of theory; solvent effects were modeled by using the CPCM method. Nine tautomers of 2 were examined. Our data showed that the generally accepted molecular structure of 2 corresponds to the most stable tautomer in both gas phase and aqueous solution. In aqueous solution, the quinone methide tautomer was the second most stable structure, being destabilized by 6 kcal mol-1. In contrast, gas-phase DFT calculations on four tautomers of 3 suggest this compound exists as a mixture of two tautomers, the quinone and the quinone methide. The relative concentration of the quinone methide is predicted to be sufficient to be detected experimentally. The energy difference between these two tautomers increases in solution so concentration of quinone methide should be negligible in polar solvents. Vertical excitation energies ...

Cardiovascular fitness as related to leg strength in adults with mental retardation.

Abstract: The purpose of this study was to compare cardiovascular fitness to leg strength of young adults (mean age = 25.2 yr) with mental retardation (MR) with and without Down syndrome (DS) and to determine whether a relationship exists. Thirteen adults (9 males, 4 females) with DS and 24 adults (16 males, 8 females) with MR but without DS participated in this study. Cardiovascular capacity (VO2peak) for each subject was determined by a treadmill test (GXT) and isokinetic knee flexion and extension strength (peak torque and average power) were determined by isokinetic dynamometry. Results generally demonstrated significant positive relationships (P < 0.05) between VO2peak and isokinetic leg strength (r = 0.61), with the relationship being substantial mainly for subjects with Down syndrome (r = 0.84). The results of this study suggest that leg strength may be an important contributor to VO2peak for persons with mental retardation.