Activated Pancreatic Stellate Cells Sequester CD8+ T Cells to Reduce Their Infiltration of the Juxtatumoral Compartment of Pancreatic Ductal Adenocarcinoma
Abasi Ene–Obong,Andrew Clear,Jennifer Watt,Jennifer Watt,Jun Wang,Rewas Fatah,John Riches,John Marshall,Jo-Anne Chin Aleong,Claude Chelala,John G. Gribben,Alan G. Ramsay,Hemant M. Kocher,Hemant M. Kocher +13 more
TLDR
Based on studies of human PDAC samples and KPC mice, activated PSCs appear to reduce migration of CD8(+) T cells to juxtatumoral stromal compartments, preventing their access to cancer cells.About:
This article is published in Gastroenterology.The article was published on 2013-11-01 and is currently open access. It has received 407 citations till now. The article focuses on the topics: Pancreatic stellate cell & Regulatory T cell.read more
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Dissertation
Identification and evaluation of circulating biomarkers for pancreatic cancer and their correlation with pancreatic stromal expression
TL;DR: In this article, a glycoprotein (dubbed Liv1) was identified as a potential diagnostic biomarker in PDAC patient sera compared to patients with chronic pancreatitis (CP), a finding that was subsequently validated in an independent cohort of samples.
Journal ArticleDOI
A Case Report on Longitudinal Collection of Tumour Biopsies for Gene Expression-Based Tumour Microenvironment Analysis from Pancreatic Cancer Patients Treated with Endoscopic Ultrasound Guided Radiofrequency Ablation
Patrick Varun Lawrence,Krisha Desai,Christopher A. Wadsworth,Nagina Mangal,Hemant M. Kocher,Nagy A. Habib,Anguraj Sadanandam,Mikael H. Sodergren +7 more
TL;DR: This case study suggests longitudinal EUS-FNAB as a potential resource to study tumour and microenvironmental changes associated with RFA treatment and suggests a large sample size is required in the future to assess the efficacy and safety of the treatment and perform comprehensive statistical analysis.
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The tumor–stroma ratio and the immune microenvironment improve the prognostic prediction of pancreatic ductal adenocarcinoma
Yi Zou,Pei-fen Fu,Yuyang Li,Pengcheng Wang,Guoping Li,Yupeng Chen,Guoping Guan,Shuang Zhang,Linying Chen +8 more
TL;DR: In this article , the authors evaluated the tumor microenvironment (TME) of pancreatic ductal adenocarcinoma (PDAC) patients in terms of the quantity and location of cluster of differentiation (CD)4+ T cells, CD8+T cells, macrophages, stromal maturity, and tumor-stroma ratio (TSR), as evaluated by immunohistochemical staining of serial whole-tissue sections.
Journal Article
CXCL5 knockdown attenuated gemcitabine resistance of pancreatic cancer through regulation of cancer cells and tumour stroma.
TL;DR: In this paper , the role of C-X-C motif chemokine 5 (CXCL5) in pancreatic cancer response to gemcitabine was investigated and the mechanisms involved were also explored by determining the changes in the tumour microenvironment (TME) and protein profile of the CXCL-5 KD cells using immune-staining and proteomic analysis.
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Expression of PD-L1 and VISTA in intraductal papillary mucinous neoplasm with associated invasive carcinoma of the pancreas.
TL;DR: In this article , the authors investigated the immune microenvironment of IPMN with associated invasive carcinoma using immunohistochemistry, and compared their correlations with clinicopathologic variables and prognosis, and found that a higher number of macrophages predicted poorer prognosis.
References
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Type, Density, and Location of Immune Cells Within Human Colorectal Tumors Predict Clinical Outcome
Jérôme Galon,Anne Costes,Fátima Sánchez-Cabo,Amos Kirilovsky,Bernhard Mlecnik,Christine Lagorce-Pagès,Marie Tosolini,Matthieu Camus,Anne Berger,Philippe Wind,Franck Zinzindohoué,Patrick Bruneval,Paul-Henri Cugnenc,Zlatko Trajanoski,Wolf H. Fridman,Franck Pagès +15 more
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Cancer Immunoediting: Integrating Immunity’s Roles in Cancer Suppression and Promotion
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Intratumoral T cells, recurrence, and survival in epithelial ovarian cancer.
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Inhibition of Hedgehog Signaling Enhances Delivery of Chemotherapy in a Mouse Model of Pancreatic Cancer
Kenneth P. Olive,Michael A. Jacobetz,Christian Davidson,Aarthi Gopinathan,Aarthi Gopinathan,Dominick J.O. McIntyre,Davina J. Honess,Basetti Madhu,Mae A. Goldgraben,Meredith E. Caldwell,David Allard,Kristopher K. Frese,Gina M. DeNicola,Gina M. DeNicola,Christine Feig,Chelsea Combs,Stephen P. Winter,Heather Ireland-Zecchini,Stefanie Reichelt,William J. Howat,Alex R. Chang,Mousumi Dhara,Lifu Wang,Lifu Wang,Felix Rückert,Robert Grützmann,Christian Pilarsky,Kamel Izeradjene,Sunil R. Hingorani,Pearl S. Huang,Susan E. Davies,William Plunkett,Merrill J. Egorin,Ralph H. Hruban,Nigel Whitebread,Karen McGovern,Julian Adams,Christine A. Iacobuzio-Donahue,John R. Griffiths,David A. Tuveson +39 more
TL;DR: Studying a mouse model of PDA that is refractory to the clinically used drug gemcitabine, it is found that the tumors in this model were poorly perfused and poorly vascularized, properties that are shared with human PDA.
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