Activated Pancreatic Stellate Cells Sequester CD8+ T Cells to Reduce Their Infiltration of the Juxtatumoral Compartment of Pancreatic Ductal Adenocarcinoma
Abasi Ene–Obong,Andrew Clear,Jennifer Watt,Jennifer Watt,Jun Wang,Rewas Fatah,John Riches,John Marshall,Jo-Anne Chin Aleong,Claude Chelala,John G. Gribben,Alan G. Ramsay,Hemant M. Kocher,Hemant M. Kocher +13 more
TLDR
Based on studies of human PDAC samples and KPC mice, activated PSCs appear to reduce migration of CD8(+) T cells to juxtatumoral stromal compartments, preventing their access to cancer cells.About:
This article is published in Gastroenterology.The article was published on 2013-11-01 and is currently open access. It has received 407 citations till now. The article focuses on the topics: Pancreatic stellate cell & Regulatory T cell.read more
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Dissecting FGF Signalling to Target Cellular Crosstalk in Pancreatic Cancer.
Edward P. Carter,Abigail S. Coetzee,Elena Tomas Bort,Qiaoying Wang,Hemant M. Kocher,Richard Grose +5 more
TL;DR: In this paper, the authors describe the mechanisms by which FGFR signalling contributes to PDAC progression, focusing on its interaction with other pathways in signalling networks and discuss the therapeutic approaches that are being developed to try and improve prognosis for this terrible disease.
Journal ArticleDOI
Targeting the Stroma in the Management of Pancreatic Cancer.
TL;DR: In this paper, the authors review the latest available evidence on novel stroma-targeting approaches, highlighting the potential impact of the stroma as a key component of the TME in PC.
Journal ArticleDOI
Targeting cancer-associated fibroblasts: Challenges, opportunities and future directions.
TL;DR: Recent single-cell transcriptomic studies have advanced the understanding of fibroblast phenotypes in normal tissues and cancers, allowing for a more precise characterisation of CAF subsets and providing opportunities to develop new therapies.
Journal ArticleDOI
Signaling pathways in cancer‐associated fibroblasts: recent advances and future perspectives
Zengli Fang,Qingcai Meng,Jin Xu,Wei Wang,Bo Zhang,Jiang-Kun Liu,Chen Liang,Jie Hua,Yingjun Zhao,Xianjun Yu,Si Shi +10 more
TL;DR: A comprehensive understanding of the signaling cascades in CAFs might help us better understand the roles of CAFs and the tumor microenvironment in cancer progression and may facilitate the development of more efficient and safer stroma-targeted cancer therapies as discussed by the authors .
Journal ArticleDOI
VentX expression in tumor-associated macrophages promotes phagocytosis and immunity against pancreatic cancers
TL;DR: It is demonstrated that VentX is required for phagocytosis and that restoration of VentX expression in PDA-TAMs promotes phagcytosis through regulating the signaling cascades involved in the process.
References
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Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources.
TL;DR: By following this protocol, investigators are able to gain an in-depth understanding of the biological themes in lists of genes that are enriched in genome-scale studies.
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Type, Density, and Location of Immune Cells Within Human Colorectal Tumors Predict Clinical Outcome
Jérôme Galon,Anne Costes,Fátima Sánchez-Cabo,Amos Kirilovsky,Bernhard Mlecnik,Christine Lagorce-Pagès,Marie Tosolini,Matthieu Camus,Anne Berger,Philippe Wind,Franck Zinzindohoué,Patrick Bruneval,Paul-Henri Cugnenc,Zlatko Trajanoski,Wolf H. Fridman,Franck Pagès +15 more
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Cancer Immunoediting: Integrating Immunity’s Roles in Cancer Suppression and Promotion
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Intratumoral T cells, recurrence, and survival in epithelial ovarian cancer.
Lin Zhang,Jose R. Conejo-Garcia,Dionyssios Katsaros,Phyllis A. Gimotty,Marco Massobrio,Giorgia Regnani,Antonis Makrigiannakis,Heidi J. Gray,Katia Schlienger,Michael N. Liebman,Stephen C. Rubin,George Coukos +11 more
TL;DR: The presence of intratumoral T cells correlates with improved clinical outcome in advanced ovarian carcinoma and was associated with increased expression of interferon-gamma, interleukin-2, and lymphocyte-attracting chemokines within the tumor.
Journal ArticleDOI
Inhibition of Hedgehog Signaling Enhances Delivery of Chemotherapy in a Mouse Model of Pancreatic Cancer
Kenneth P. Olive,Michael A. Jacobetz,Christian Davidson,Aarthi Gopinathan,Aarthi Gopinathan,Dominick J.O. McIntyre,Davina J. Honess,Basetti Madhu,Mae A. Goldgraben,Meredith E. Caldwell,David Allard,Kristopher K. Frese,Gina M. DeNicola,Gina M. DeNicola,Christine Feig,Chelsea Combs,Stephen P. Winter,Heather Ireland-Zecchini,Stefanie Reichelt,William J. Howat,Alex R. Chang,Mousumi Dhara,Lifu Wang,Lifu Wang,Felix Rückert,Robert Grützmann,Christian Pilarsky,Kamel Izeradjene,Sunil R. Hingorani,Pearl S. Huang,Susan E. Davies,William Plunkett,Merrill J. Egorin,Ralph H. Hruban,Nigel Whitebread,Karen McGovern,Julian Adams,Christine A. Iacobuzio-Donahue,John R. Griffiths,David A. Tuveson +39 more
TL;DR: Studying a mouse model of PDA that is refractory to the clinically used drug gemcitabine, it is found that the tumors in this model were poorly perfused and poorly vascularized, properties that are shared with human PDA.
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