Activated Pancreatic Stellate Cells Sequester CD8+ T Cells to Reduce Their Infiltration of the Juxtatumoral Compartment of Pancreatic Ductal Adenocarcinoma
Abasi Ene–Obong,Andrew Clear,Jennifer Watt,Jennifer Watt,Jun Wang,Rewas Fatah,John Riches,John Marshall,Jo-Anne Chin Aleong,Claude Chelala,John G. Gribben,Alan G. Ramsay,Hemant M. Kocher,Hemant M. Kocher +13 more
TLDR
Based on studies of human PDAC samples and KPC mice, activated PSCs appear to reduce migration of CD8(+) T cells to juxtatumoral stromal compartments, preventing their access to cancer cells.About:
This article is published in Gastroenterology.The article was published on 2013-11-01 and is currently open access. It has received 407 citations till now. The article focuses on the topics: Pancreatic stellate cell & Regulatory T cell.read more
Citations
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Turning foes to friends: targeting cancer-associated fibroblasts
Xueman Chen,Erwei Song +1 more
TL;DR: The progress made to date and the remaining challenges in bringing CAF-targeted therapies to the clinic are highlighted and the relevant translational advances and potential therapeutic strategies that target CAFs for cancer treatment are highlighted.
Journal ArticleDOI
Cancer-associated fibroblasts: an emerging target of anti-cancer immunotherapy.
TL;DR: Current understanding of the tumorigenic significance, origin, and heterogeneity of CAFs, as well as the roles of different CAFs subtypes in distinct immune cell types are described.
Journal ArticleDOI
Obstacles Posed by the Tumor Microenvironment to T cell Activity: A Case for Synergistic Therapies
TL;DR: How the tumor and its microenvironment influences T cell trafficking and function with a focus on melanoma, and pancreatic and ovarian cancer, is discussed, and how scientific advances may help overcome these hurdles are discussed.
Journal ArticleDOI
Lactate Regulates Metabolic and Pro-inflammatory Circuits in Control of T Cell Migration and Effector Functions.
Robert Haas,Joanne Smith,Vidalba Rocher-Ros,Suchita Nadkarni,Trinidad Montero-Melendez,Fulvio D'Acquisto,Elliot James Bland,Michele Bombardieri,Costantino Pitzalis,Mauro Perretti,Federica M. Marelli-Berg,Claudio Mauro +11 more
TL;DR: A novel role of lactate is established in control of proinflammatory T cell motility and effector functions, which provides a potential molecular mechanism for T cell entrapment and functional changes in inflammatory sites that drive chronic inflammation and offer targeted therapeutic interventions for the treatment of chronic inflammatory disorders.
Journal ArticleDOI
Stromal biology and therapy in pancreatic cancer: a changing paradigm
TL;DR: Recent data have shown that tumour-associated fibroblasts may restrain rather than promote tumour growth, reinforcing the need to critically revisit the complexity and complicity of the tumour–stroma with translational implications for future therapy and clinical trial design.
References
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Journal ArticleDOI
T cells from CLL patients exhibit features of T-cell exhaustion but retain capacity for cytokine production.
John Riches,Jeff K. Davies,Fabienne McClanahan,Rewas Fatah,Sameena Iqbal,Samir G. Agrawal,Alan G. Ramsay,John G. Gribben +7 more
TL;DR: Although CLL CD8+ T cells exhibit features of T-cell exhaustion, they retain the ability to produce cytokines, and these findings also exclude CMV as the sole cause ofT-cell defects in CLL.
Journal ArticleDOI
A Starring Role for Stellate Cells in the Pancreatic Cancer Microenvironment
Minoti V. Apte,Jeremy S. Wilson,Aurelia Lugea,Aurelia Lugea,Stephen J. Pandol,Stephen J. Pandol,Stephen J. Pandol +6 more
TL;DR: The background and recent advances in pancreatic cancer research began to change with the identification of pancreatic stellate cells, which produce the pancreatic tumor stroma, along with important areas of future research that could improve therapy.
Journal ArticleDOI
Pancreatic Cancer-Associated Stellate Cells Promote Differentiation of Myeloid-Derived Suppressor Cells in a STAT3-Dependent Manner
Thomas A. Mace,Zeenath Ameen,Amy L. Collins,Sylwia E. Wojcik,Markus Mair,Gregory S. Young,James R. Fuchs,Timothy D. Eubank,Wendy L. Frankel,Tanios Bekaii-Saab,Mark Bloomston,Gregory B. Lesinski +11 more
TL;DR: A novel role for PSC is identified in driving immune escape in pancreatic cancer and the evidence that STAT3 acts as a driver of stromal immunosuppression to enhance its interest as a therapeutic target is extended.
Journal ArticleDOI
Retinoic Acid--Induced Pancreatic Stellate Cell Quiescence Reduces Paracrine Wnt-β-Catenin Signaling to Slow Tumor Progression
Fieke E. M. Froeling,Christine Feig,Claude Chelala,Richard Dobson,Charles Mein,David A. Tuveson,Hans Clevers,Ian R. Hart,Hemant M. Kocher +8 more
TL;DR: RA induces quiescence and reduces motility of PSCs, leading to reduced proliferation and increased apoptosis of surrounding pancreatic cancer cells, and RA isoforms might be developed as therapeutic reagents for pancreaticcancer.
Journal ArticleDOI
Discovery of Novel Tumor Markers of Pancreatic Cancer using Global Gene Expression Technology
Christine A. Iacobuzio-Donahue,Anirban Maitra,Grace L. C. Shen-Ong,Tjarda van Heek,Raheela Ashfaq,Renee Meyer,Kimberly Walter,Karin D. Berg,Michael A. Hollingsworth,John L. Cameron,Charles J. Yeo,Scott E. Kern,Michael Goggins,Ralph H. Hruban +13 more
TL;DR: One hundred eighty fragments were identified as having fivefold or greater expression levels in pancreas cancer specimens as compared to normal tissue, of which 124 corresponded to known genes and 56 to ESTs.
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