Activated Pancreatic Stellate Cells Sequester CD8+ T Cells to Reduce Their Infiltration of the Juxtatumoral Compartment of Pancreatic Ductal Adenocarcinoma
Abasi Ene–Obong,Andrew Clear,Jennifer Watt,Jennifer Watt,Jun Wang,Rewas Fatah,John Riches,John Marshall,Jo-Anne Chin Aleong,Claude Chelala,John G. Gribben,Alan G. Ramsay,Hemant M. Kocher,Hemant M. Kocher +13 more
TLDR
Based on studies of human PDAC samples and KPC mice, activated PSCs appear to reduce migration of CD8(+) T cells to juxtatumoral stromal compartments, preventing their access to cancer cells.About:
This article is published in Gastroenterology.The article was published on 2013-11-01 and is currently open access. It has received 407 citations till now. The article focuses on the topics: Pancreatic stellate cell & Regulatory T cell.read more
Citations
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Emerging roles of the CXCL12/CXCR4 axis in pancreatic cancer progression and therapy
Richard Sleightholm,Beth K. Neilsen,Jing Li,Maria M. Steele,Rakesh K. Singh,Michael A. Hollingsworth,David Oupicky +6 more
TL;DR: The CXCR4 receptor, in conjunction with its primary chemokine ligand CXCL12, promotes pancreatic cancer development, invasion, and metastasis through the management of the tumor microenvironment via complex crosstalk with other pathways.
Journal ArticleDOI
Checkpoint inhibitors in pancreatic cancer.
TL;DR: Overall, PC patients treated with checkpoint inhibitors were not shown to elicit improvement in response rates or overall survival, and combination regimens including chemotherapy have shown initial promise, but these results need to be verified.
Journal ArticleDOI
The impact of cancer-associated fibroblasts on major hallmarks of pancreatic cancer.
TL;DR: An improved understanding of the impact of CAFs on the major hallmarks of PDAC will highlight the diagnostic and therapeutic values of these targeted cells.
Journal ArticleDOI
Pancreatic stellate cell: Pandora's box for pancreatic disease biology.
Ratnakar R. Bynigeri,Aparna Jakkampudi,Ramaiah Jangala,C. Subramanyam,Mitnala Sasikala,G Venkat Rao,D. Nageshwar Reddy,Rupjyoti Talukdar +7 more
TL;DR: It is shown that PSCs are involved in significant crosstalk between the pancreatic cancer cells and the cancer stroma, which result in tumour progression, metastasis, tumour hypoxia, immune evasion and drug resistance.
Journal ArticleDOI
The Balancing Act between Cancer Immunity and Autoimmunity in Response to Immunotherapy
TL;DR: Key questions in this emerging field are explored, summarizing preclinical and clinical experiences with this new generation of cancer drugs, the growing understanding of the role of the immune response in mediating these toxicities, the relationship of CPI-induced autoimmunity to conventional autoimmune diseases, and insights into the mechanism of irAE development and treatment.
References
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TL;DR: By following this protocol, investigators are able to gain an in-depth understanding of the biological themes in lists of genes that are enriched in genome-scale studies.
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Type, Density, and Location of Immune Cells Within Human Colorectal Tumors Predict Clinical Outcome
Jérôme Galon,Anne Costes,Fátima Sánchez-Cabo,Amos Kirilovsky,Bernhard Mlecnik,Christine Lagorce-Pagès,Marie Tosolini,Matthieu Camus,Anne Berger,Philippe Wind,Franck Zinzindohoué,Patrick Bruneval,Paul-Henri Cugnenc,Zlatko Trajanoski,Wolf H. Fridman,Franck Pagès +15 more
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Lin Zhang,Jose R. Conejo-Garcia,Dionyssios Katsaros,Phyllis A. Gimotty,Marco Massobrio,Giorgia Regnani,Antonis Makrigiannakis,Heidi J. Gray,Katia Schlienger,Michael N. Liebman,Stephen C. Rubin,George Coukos +11 more
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Inhibition of Hedgehog Signaling Enhances Delivery of Chemotherapy in a Mouse Model of Pancreatic Cancer
Kenneth P. Olive,Michael A. Jacobetz,Christian Davidson,Aarthi Gopinathan,Aarthi Gopinathan,Dominick J.O. McIntyre,Davina J. Honess,Basetti Madhu,Mae A. Goldgraben,Meredith E. Caldwell,David Allard,Kristopher K. Frese,Gina M. DeNicola,Gina M. DeNicola,Christine Feig,Chelsea Combs,Stephen P. Winter,Heather Ireland-Zecchini,Stefanie Reichelt,William J. Howat,Alex R. Chang,Mousumi Dhara,Lifu Wang,Lifu Wang,Felix Rückert,Robert Grützmann,Christian Pilarsky,Kamel Izeradjene,Sunil R. Hingorani,Pearl S. Huang,Susan E. Davies,William Plunkett,Merrill J. Egorin,Ralph H. Hruban,Nigel Whitebread,Karen McGovern,Julian Adams,Christine A. Iacobuzio-Donahue,John R. Griffiths,David A. Tuveson +39 more
TL;DR: Studying a mouse model of PDA that is refractory to the clinically used drug gemcitabine, it is found that the tumors in this model were poorly perfused and poorly vascularized, properties that are shared with human PDA.
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