Activated Pancreatic Stellate Cells Sequester CD8+ T Cells to Reduce Their Infiltration of the Juxtatumoral Compartment of Pancreatic Ductal Adenocarcinoma
Abasi Ene–Obong,Andrew Clear,Jennifer Watt,Jennifer Watt,Jun Wang,Rewas Fatah,John Riches,John Marshall,Jo-Anne Chin Aleong,Claude Chelala,John G. Gribben,Alan G. Ramsay,Hemant M. Kocher,Hemant M. Kocher +13 more
TLDR
Based on studies of human PDAC samples and KPC mice, activated PSCs appear to reduce migration of CD8(+) T cells to juxtatumoral stromal compartments, preventing their access to cancer cells.About:
This article is published in Gastroenterology.The article was published on 2013-11-01 and is currently open access. It has received 407 citations till now. The article focuses on the topics: Pancreatic stellate cell & Regulatory T cell.read more
Citations
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Inhibition of PAK1 suppresses pancreatic cancer by stimulation of anti-tumour immunity through down-regulation of PD-L1.
Kai Wang,Yifan Zhan,Yifan Zhan,Nhi Huynh,Chelsea Dumesny,Xiao Wang,Khashayer Asadi,David Herrmann,David Herrmann,Paul Timpson,Paul Timpson,Yang Yang,Katrina A Walsh,Graham S. Baldwin,Mehrdad Nikfarjam,Hong S. He +15 more
TL;DR: In PDA patients low PAK1 expression, low activation of PSC and high CD8+ T cell/PAK1 ratios correlated with longer overall survival, which may result in improved efficacy of immunotherapy of PDA.
Journal ArticleDOI
PEDF inhibits pancreatic tumorigenesis by attenuating the fibro-inflammatory reaction
Daniel R. Principe,Brian DeCant,Andrew M. Diaz,Riley J. Mangan,Rosa F. Hwang,Andrew M. Lowy,Brandon B. Shetuni,Bharath K. Sreekumar,Chuhan Chung,David J. Bentrem,Hidayatullah G. Munshi,Barbara Jung,Paul J. Grippo,Faraz Bishehsari +13 more
TL;DR: It is demonstrated that PEDF limits pancreatic cancer progression by attenuating the fibro-inflammatory reaction, and makes restoration of PEDf signaling a potential therapeutic approach to study in Pancreatic cancer.
Journal ArticleDOI
New directions in chimeric antigen receptor T cell [CAR-T] therapy and related flow cytometry
TL;DR: The current state of CAR T therapy is summarized, the areas of emergent research, applications of flow cytometry in modern cell therapy are discussed, and several considerations particular to CAR detection and assessing the effectiveness ofCAR T therapy are touched upon.
Journal ArticleDOI
The dynamic interactions between the stroma, pancreatic stellate cells and pancreatic tumor development: Novel therapeutic targets
TL;DR: The role of the stroma and PSCs in PC development, invasion and metastasis is explored, their interaction with PC cells is examined, and potential treatment approaches aimed at targeting P SCs in order to reprogram the pancreatic tumor environment are discussed.
Journal ArticleDOI
Immunologic Strategies in Pancreatic Cancer: Making <i>Cold</i> Tumors <i>Hot</i>
TL;DR: The authors summarized the mechanisms of immunosuppression within the PDAC tumor microenvironment and provided an up-to-date review of completed and ongoing clinical trials using various immunotherapy strategies.
References
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Type, Density, and Location of Immune Cells Within Human Colorectal Tumors Predict Clinical Outcome
Jérôme Galon,Anne Costes,Fátima Sánchez-Cabo,Amos Kirilovsky,Bernhard Mlecnik,Christine Lagorce-Pagès,Marie Tosolini,Matthieu Camus,Anne Berger,Philippe Wind,Franck Zinzindohoué,Patrick Bruneval,Paul-Henri Cugnenc,Zlatko Trajanoski,Wolf H. Fridman,Franck Pagès +15 more
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Cancer Immunoediting: Integrating Immunity’s Roles in Cancer Suppression and Promotion
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Intratumoral T cells, recurrence, and survival in epithelial ovarian cancer.
Lin Zhang,Jose R. Conejo-Garcia,Dionyssios Katsaros,Phyllis A. Gimotty,Marco Massobrio,Giorgia Regnani,Antonis Makrigiannakis,Heidi J. Gray,Katia Schlienger,Michael N. Liebman,Stephen C. Rubin,George Coukos +11 more
TL;DR: The presence of intratumoral T cells correlates with improved clinical outcome in advanced ovarian carcinoma and was associated with increased expression of interferon-gamma, interleukin-2, and lymphocyte-attracting chemokines within the tumor.
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Inhibition of Hedgehog Signaling Enhances Delivery of Chemotherapy in a Mouse Model of Pancreatic Cancer
Kenneth P. Olive,Michael A. Jacobetz,Christian Davidson,Aarthi Gopinathan,Aarthi Gopinathan,Dominick J.O. McIntyre,Davina J. Honess,Basetti Madhu,Mae A. Goldgraben,Meredith E. Caldwell,David Allard,Kristopher K. Frese,Gina M. DeNicola,Gina M. DeNicola,Christine Feig,Chelsea Combs,Stephen P. Winter,Heather Ireland-Zecchini,Stefanie Reichelt,William J. Howat,Alex R. Chang,Mousumi Dhara,Lifu Wang,Lifu Wang,Felix Rückert,Robert Grützmann,Christian Pilarsky,Kamel Izeradjene,Sunil R. Hingorani,Pearl S. Huang,Susan E. Davies,William Plunkett,Merrill J. Egorin,Ralph H. Hruban,Nigel Whitebread,Karen McGovern,Julian Adams,Christine A. Iacobuzio-Donahue,John R. Griffiths,David A. Tuveson +39 more
TL;DR: Studying a mouse model of PDA that is refractory to the clinically used drug gemcitabine, it is found that the tumors in this model were poorly perfused and poorly vascularized, properties that are shared with human PDA.
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