Activated Pancreatic Stellate Cells Sequester CD8+ T Cells to Reduce Their Infiltration of the Juxtatumoral Compartment of Pancreatic Ductal Adenocarcinoma
Abasi Ene–Obong,Andrew Clear,Jennifer Watt,Jennifer Watt,Jun Wang,Rewas Fatah,John Riches,John Marshall,Jo-Anne Chin Aleong,Claude Chelala,John G. Gribben,Alan G. Ramsay,Hemant M. Kocher,Hemant M. Kocher +13 more
TLDR
Based on studies of human PDAC samples and KPC mice, activated PSCs appear to reduce migration of CD8(+) T cells to juxtatumoral stromal compartments, preventing their access to cancer cells.About:
This article is published in Gastroenterology.The article was published on 2013-11-01 and is currently open access. It has received 407 citations till now. The article focuses on the topics: Pancreatic stellate cell & Regulatory T cell.read more
Citations
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Inflammation and pancreatic cancer: disease promoter and new therapeutic target
TL;DR: This review summarizes current knowledge about the tumor-promoting stromal functions, immune system modulation and therapeutic strategies targeting tumor-stromal interactions in pancreatic cancer.
Journal ArticleDOI
Emerging nanomedicines for anti-stromal therapy against desmoplastic tumors
Xuexiang Han,Ying Xu,Marzieh Geranpayehvaghei,Gregory J. Anderson,Yiye Li,Yiye Li,Guangjun Nie,Guangjun Nie +7 more
TL;DR: The major components of the tumor stroma are reviewed and the potential of nano-enabled anti-stromal therapy to enhance the anti-tumor efficacy of other therapeutic modalities, including chemotherapy, immunotherapy, phototherapy and radiotherapy is examined.
Journal ArticleDOI
Proimmunogenic impact of MEK inhibition synergizes with agonist anti-CD40 immunostimulatory antibodies in tumor therapy
Daniel Baumann,Tanja Hägele,Julian Mochayedi,Jennifer Drebant,Caroline Vent,Caroline Vent,Sven Blobner,Julia Han Noll,Irena Nickel,Corinna Schumacher,Sophie L. Boos,Aline Sophie Daniel,Susann Wendler,Susann Wendler,Michael Volkmar,Michael Volkmar,Oliver Strobel,Rienk Offringa,Rienk Offringa +18 more
TL;DR: It is shown that combining MEK inhibition with an agonist anti-CD40 immunostimulatory antibody improves antitumor treatment by inducing immunogenic changes in the tumor microenvironment.
Journal ArticleDOI
YAP1-mediated pancreatic stellate cell activation inhibits pancreatic cancer cell proliferation.
Ying Xiao,Hui Zhang,Qiang Ma,Rui Huang,Junliang Lu,Xiaolong Liang,Xuguang Liu,Zhiwen Zhang,Lianyuan Yu,Junyi Pang,Liangrui Zhou,Tonghua Liu,Tonghua Liu,Huanwen Wu,Huanwen Wu,Zhiyong Liang,Zhiyong Liang +16 more
TL;DR: This study revealed a critical role for YAP1 in the regulation of PSC activation and paracrine signaling and provides insights into a novel rationale for targeting Yap1 to reprogram the PDAC microenvironment.
Journal ArticleDOI
Extracellular Influences: Molecular Subclasses and the Microenvironment in Pancreatic Cancer
TL;DR: An overview of the available evidence is given by delineating the elements of the PDAC stroma and their contribution to tumour growth by interpreting the heterogeneity at the gene expression level in PDAC, and how stromal elements contribute to, or interconnect, with this.
References
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Type, Density, and Location of Immune Cells Within Human Colorectal Tumors Predict Clinical Outcome
Jérôme Galon,Anne Costes,Fátima Sánchez-Cabo,Amos Kirilovsky,Bernhard Mlecnik,Christine Lagorce-Pagès,Marie Tosolini,Matthieu Camus,Anne Berger,Philippe Wind,Franck Zinzindohoué,Patrick Bruneval,Paul-Henri Cugnenc,Zlatko Trajanoski,Wolf H. Fridman,Franck Pagès +15 more
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Inhibition of Hedgehog Signaling Enhances Delivery of Chemotherapy in a Mouse Model of Pancreatic Cancer
Kenneth P. Olive,Michael A. Jacobetz,Christian Davidson,Aarthi Gopinathan,Aarthi Gopinathan,Dominick J.O. McIntyre,Davina J. Honess,Basetti Madhu,Mae A. Goldgraben,Meredith E. Caldwell,David Allard,Kristopher K. Frese,Gina M. DeNicola,Gina M. DeNicola,Christine Feig,Chelsea Combs,Stephen P. Winter,Heather Ireland-Zecchini,Stefanie Reichelt,William J. Howat,Alex R. Chang,Mousumi Dhara,Lifu Wang,Lifu Wang,Felix Rückert,Robert Grützmann,Christian Pilarsky,Kamel Izeradjene,Sunil R. Hingorani,Pearl S. Huang,Susan E. Davies,William Plunkett,Merrill J. Egorin,Ralph H. Hruban,Nigel Whitebread,Karen McGovern,Julian Adams,Christine A. Iacobuzio-Donahue,John R. Griffiths,David A. Tuveson +39 more
TL;DR: Studying a mouse model of PDA that is refractory to the clinically used drug gemcitabine, it is found that the tumors in this model were poorly perfused and poorly vascularized, properties that are shared with human PDA.
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