Activated Pancreatic Stellate Cells Sequester CD8+ T Cells to Reduce Their Infiltration of the Juxtatumoral Compartment of Pancreatic Ductal Adenocarcinoma
Abasi Ene–Obong,Andrew Clear,Jennifer Watt,Jennifer Watt,Jun Wang,Rewas Fatah,John Riches,John Marshall,Jo-Anne Chin Aleong,Claude Chelala,John G. Gribben,Alan G. Ramsay,Hemant M. Kocher,Hemant M. Kocher +13 more
TLDR
Based on studies of human PDAC samples and KPC mice, activated PSCs appear to reduce migration of CD8(+) T cells to juxtatumoral stromal compartments, preventing their access to cancer cells.About:
This article is published in Gastroenterology.The article was published on 2013-11-01 and is currently open access. It has received 407 citations till now. The article focuses on the topics: Pancreatic stellate cell & Regulatory T cell.read more
Citations
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Kras and Tumor Immunity: Friend or Foe?
TL;DR: This review focuses on how mutant Kras tumor cells contribute to tumor immunity, with a specific focus on processes induced directly or indirectly by the oncogene.
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Mechanisms of T-Cell Exhaustion in Pancreatic Cancer
Didem Saka,Muazzez Gökalp,Betul Piyade,Nedim Can Cevik,Elif Arik Sever,Derya Unutmaz,Güralp O. Ceyhan,Ihsan Ekin Demir,Hande Asimgil +8 more
TL;DR: Recent studies utilizing transcriptomics, mass cytometry, and epigenomics revealed a critical role of Thymocyte selection-associated high mobility group box protein (TOX) genes and TOX-associated pathways, driving T-cell exhaustion in chronic infection and cancer.
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Stromal protein βig-h3 reprogrammes tumour microenvironment in pancreatic cancer.
Delphine Goehrig,Delphine Goehrig,Jérémy Nigri,Rémi Samain,Zhichong Wu,Zhichong Wu,Paola Cappello,Gaëlle Gabiane,Gaëlle Gabiane,Xinyi Zhang,Xinyi Zhang,Yajie Zhao,Yajie Zhao,In San Kim,M. Chanal,M. Chanal,Roberta Curto,Valérie Hervieu,Christelle De La Fouchardiere,Francesco Novelli,Pascale Milani,Richard Tomasini,Corinne Bousquet,Philippe Bertolino,Philippe Bertolino,Ana Hennino,Ana Hennino +26 more
TL;DR: The data indicate that targeting stromal extracellular matrix protein βig-h3 improves the antitumoural response and consequently reduces tumour weight.
Journal ArticleDOI
Stromal remodeling by the BET bromodomain inhibitor JQ1 suppresses the progression of human pancreatic cancer.
Keisuke Yamamoto,Keisuke Tateishi,Yotaro Kudo,Mayumi Hoshikawa,Mariko Tanaka,Takuma Nakatsuka,Hiroaki Fujiwara,Koji Miyabayashi,Ryota Takahashi,Yasuo Tanaka,Hideaki Ijichi,Yousuke Nakai,Hiroyuki Isayama,Yasuyuki Morishita,Taku Aoki,Taku Aoki,Yoshihiro Sakamoto,Kiyoshi Hasegawa,Norihiro Kokudo,Masashi Fukayama,Kazuhiko Koike +20 more
TL;DR: The results reveal BET proteins as the critical regulators of CAF-activation and also provide evidence that stromal remodeling by epigenetic modulators can be a novel therapeutic option for PDAC.
Journal ArticleDOI
Hypoxia induces core-to-edge transition of progressive tumoral cells: A critical review on differential yet corroborative roles for HIF-1α and HIF-2α.
TL;DR: It would be fair to announce that combine targeting for both hypoxia inducible factor (HIF)-1α and HIF-2α may hold a therapeutic promise for high-stage tumors, but an ongoing research is required to direct this hypothesis toward certainty.
References
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Type, Density, and Location of Immune Cells Within Human Colorectal Tumors Predict Clinical Outcome
Jérôme Galon,Anne Costes,Fátima Sánchez-Cabo,Amos Kirilovsky,Bernhard Mlecnik,Christine Lagorce-Pagès,Marie Tosolini,Matthieu Camus,Anne Berger,Philippe Wind,Franck Zinzindohoué,Patrick Bruneval,Paul-Henri Cugnenc,Zlatko Trajanoski,Wolf H. Fridman,Franck Pagès +15 more
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Inhibition of Hedgehog Signaling Enhances Delivery of Chemotherapy in a Mouse Model of Pancreatic Cancer
Kenneth P. Olive,Michael A. Jacobetz,Christian Davidson,Aarthi Gopinathan,Aarthi Gopinathan,Dominick J.O. McIntyre,Davina J. Honess,Basetti Madhu,Mae A. Goldgraben,Meredith E. Caldwell,David Allard,Kristopher K. Frese,Gina M. DeNicola,Gina M. DeNicola,Christine Feig,Chelsea Combs,Stephen P. Winter,Heather Ireland-Zecchini,Stefanie Reichelt,William J. Howat,Alex R. Chang,Mousumi Dhara,Lifu Wang,Lifu Wang,Felix Rückert,Robert Grützmann,Christian Pilarsky,Kamel Izeradjene,Sunil R. Hingorani,Pearl S. Huang,Susan E. Davies,William Plunkett,Merrill J. Egorin,Ralph H. Hruban,Nigel Whitebread,Karen McGovern,Julian Adams,Christine A. Iacobuzio-Donahue,John R. Griffiths,David A. Tuveson +39 more
TL;DR: Studying a mouse model of PDA that is refractory to the clinically used drug gemcitabine, it is found that the tumors in this model were poorly perfused and poorly vascularized, properties that are shared with human PDA.
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