DNA fragility in the parallel evolution of pelvic reduction in stickleback fish.
Kathleen T. Xie,Guliang Wang,Abbey Thompson,Julia I. Wucherpfennig,Thomas E. Reimchen,Andrew D. C. MacColl,Dolph Schluter,Michael A. Bell,Karen M. Vasquez,David M. Kingsley +9 more
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TLDR
It is shown that a pelvic enhancer gene lies within a region of the genome that is prone to double-stranded DNA breakage owing to a high thymine-guanine content, which could lead to enhanced mutation rates that facilitate repeated adaptations to new environments.Abstract:
Evolution generates a remarkable breadth of living forms, but many traits evolve repeatedly, by mechanisms that are still poorly understood. A classic example of repeated evolution is the loss of pelvic hindfins in stickleback fish (Gasterosteus aculeatus). Repeated pelvic loss maps to recurrent deletions of a pelvic enhancer of the Pitx1 gene. Here, we identify molecular features contributing to these recurrent deletions. Pitx1 enhancer sequences form alternative DNA structures in vitro and increase double-strand breaks and deletions in vivo. Enhancer mutability depends on DNA replication direction and is caused by TG-dinucleotide repeats. Modeling shows that elevated mutation rates can influence evolution under demographic conditions relevant for sticklebacks and humans. DNA fragility may thus help explain why the same loci are often used repeatedly during parallel adaptive evolution.read more
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The population genetics of structural variants in grapevine domestication
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TL;DR: This work combined phylogenomic, developmental, and epigenomic analysis of 11 new genomes of paleognathous birds to show that convergent evolution of regulatory regions, more so than protein-coding genes, is prevalent among developmental pathways associated with independent losses of flight.
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Non-B DNA: a major contributor to small- and large-scale variation in nucleotide substitution frequencies across the genome.
Wilfried Guiblet,Marzia A. Cremona,Marzia A. Cremona,Robert S. Harris,Di Chen,Kristin A. Eckert,Francesca Chiaromonte,Francesca Chiaromonte,Yi-Fei Huang,Kateryna D. Makova +9 more
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The Role of Mutation Bias in Adaptive Evolution.
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TL;DR: Little support is found for mutation bias as an independent force in adaptive evolution, although it can interact with selection under conditions of small population size and when standing genetic variation is limited, entirely consistent with standard evolutionary theory.
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