Journal ArticleDOI
Epigenetic codes in cognition and behaviour.
TLDR
Recent findings on the role and mechanisms of epigenetic codes in the brain are described, and their implication in synaptic plasticity, cognitive functions and psychiatric disorders are discussed.About:
This article is published in Behavioural Brain Research.The article was published on 2008-09-01. It has received 260 citations till now. The article focuses on the topics: Epigenetic code & Epigenetics.read more
Citations
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Book ChapterDOI
Molecular Genetic Mechanisms for Long-Term Information Storage at the Cellular Level
TL;DR: This chapter considers molecular mechanisms that are uniquely involved in triggering very long-lasting changes in synaptic transmission in memory, and discusses how changes in gene expression become manifest as changes at the synapse.
Book ChapterDOI
Pharmacogenomics and Personalized Medicine in Alzheimer’s Disease
Trevor Archer,Boo Johansson +1 more
TL;DR: The search for individual-based medication seeks to establish a “reregulation” of destructive β-amyloid pathways, an understanding and application of Aβ-linked immunotherapy, the initiation and formulation of pharmacogenetic/pharmacogenomics principles and methodologies, the emergence of the role of apolipoprotein (APOE) in therapeutic endeavor, the assessment and treatment of behavioral and psychological symptoms.
Patent
Predicting cognitive development by gene methylation analysis
Mark H. Vickers,Cyrus Cooper,Keith M. Godfrey,Karen A. Lillycrop,Graham C. Burdge,Mark A. Hanson,Peter Gluckman +6 more
TL;DR: In this article, epigenetic alteration, especially methylation, of a gene or a combination of genes, preferably in a perinatal tissue sample such as umbilical cord, was used for predicting cognitive development in an individual.
Book ChapterDOI
Epigenetic regulons in Alzheimer's disease.
TL;DR: The role of epigenetics in the onset and progression of Alzheimer's disease and the use of epigenetic therapeutics to ameliorate the constraints of AD is discussed in this article .
References
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Journal ArticleDOI
A synaptic model of memory: long-term potentiation in the hippocampus
TL;DR: The best understood form of long-term potentiation is induced by the activation of the N-methyl-d-aspartate receptor complex, which allows electrical events at the postsynaptic membrane to be transduced into chemical signals which, in turn, are thought to activate both pre- and post Synaptic mechanisms to generate a persistent increase in synaptic strength.
Journal ArticleDOI
Chromatin Modifications and Their Function
TL;DR: The surface of nucleosomes is studded with a multiplicity of modifications that can dictate the higher-order chromatin structure in which DNA is packaged and can orchestrate the ordered recruitment of enzyme complexes to manipulate DNA.
Journal ArticleDOI
Translating the Histone Code
Thomas Jenuwein,C. David Allis +1 more
TL;DR: It is proposed that this epigenetic marking system represents a fundamental regulatory mechanism that has an impact on most, if not all, chromatin-templated processes, with far-reaching consequences for cell fate decisions and both normal and pathological development.
Journal ArticleDOI
DNA methylation patterns and epigenetic memory
TL;DR: The heritability of methylation states and the secondary nature of the decision to invite or exclude methylation support the idea that DNA methylation is adapted for a specific cellular memory function in development.
Journal ArticleDOI
Epigenetic regulation of gene expression: how the genome integrates intrinsic and environmental signals
Rudolf Jaenisch,Adrian Bird +1 more
TL;DR: Advances in the understanding of the mechanism and role of DNA methylation in biological processes are reviewed, showing that epigenetic mechanisms seem to allow an organism to respond to the environment through changes in gene expression.