Journal ArticleDOI
Epigenetic codes in cognition and behaviour.
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TLDR
Recent findings on the role and mechanisms of epigenetic codes in the brain are described, and their implication in synaptic plasticity, cognitive functions and psychiatric disorders are discussed.About:
This article is published in Behavioural Brain Research.The article was published on 2008-09-01. It has received 260 citations till now. The article focuses on the topics: Epigenetic code & Epigenetics.read more
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Socioeconomic status and the developing brain
TL;DR: These studies indicate that SES is an important predictor of neurocognitive performance, particularly of language and executive function, and that S ES differences are found in neural processing even when performance levels are equal.
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Lasting epigenetic influence of early-life adversity on the BDNF gene.
TL;DR: An epigenetic molecular mechanism potentially underlying lifelong and transgenerational perpetuation of changes in gene expression and behavior incited by early abuse and neglect is highlighted.
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Transcription Factors in Long-Term Memory and Synaptic Plasticity
TL;DR: The results of this work suggest that patterns of transcription regulation represent the molecular signatures of long-term synaptic changes and memory formation.
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Histone acetylation: molecular mnemonics on the chromatin
TL;DR: As histone acetylation and cognitive functions can be pharmacologically restored by histone deacetylase inhibitors, this epigenetic modification might constitute a molecular memory aid on the chromatin and, by extension, a new template for therapeutic interventions against cognitive frailty.
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Finding the engram.
TL;DR: This Review develops four defining criteria that enable us to critically assess the recent progress that has been made towards finding the engram, and proposes that findings from 'capture' studies represent considerable progress in allowing us to observe, erase and express the engrams.
References
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Journal ArticleDOI
Global effects of histone modifications.
Hongpeng He,Norbert Lehming +1 more
TL;DR: This review aims to summarise some of the experiments that demonstrated the global effects of the modifications of the five histone proteins, H1, H 2A, H2B, H3 and H3, and the interdependence of histone methylation and DNA methylation.
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Differential epigenetic modifications in the FMR1 gene of the fragile X syndrome after reactivating pharmacological treatments
Elisabetta Tabolacci,Roberta Pietrobono,Umberto Moscato,Ben A. Oostra,Pietro Chiurazzi,Giovanni Neri +5 more
TL;DR: It is indicated that H3-K4 methylation and DNA demethylation are the main epigenetic switches activating the expression of the FMR1 gene, with histone acetylation playing an ancillary role.
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Gene silencing through methylation: An epigenetic intervention on Alzheimer disease
TL;DR: It is shown, in cell culture, that two of the genes responsible for amyloid-beta production are controlled by the methylation of their promoters, and therefore its significance and the use of this drug for the treatment of the disease are investigated.
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Placental Insufficiency Leads to Developmental Hypertension and Mesenteric Artery Dysfunction in Two Generations of Sprague-Dawley Rat Offspring
TL;DR: It is indicated that placental insufficiency during a critical developmental window in late gestation leads to hypertension in juvenile Sprague-Dawley rat offspring and is perpetuated in a second generation of offspring in a gender-specific manner.