Journal ArticleDOI
Epigenetic codes in cognition and behaviour.
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TLDR
Recent findings on the role and mechanisms of epigenetic codes in the brain are described, and their implication in synaptic plasticity, cognitive functions and psychiatric disorders are discussed.About:
This article is published in Behavioural Brain Research.The article was published on 2008-09-01. It has received 260 citations till now. The article focuses on the topics: Epigenetic code & Epigenetics.read more
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Book ChapterDOI
Histone Deacetylase Inhibitors: A Novel Therapeutic Approach for Cognitive Disorders
TL;DR: Emerging evidence indicates that increased histone acetylation through the inhibition of histone deacetylases (HDACs) can facilitate the formation of long-term memories in preclinical studies, and future HDAC-based pharmacotherapies will benefit from a greater understanding of different HDAC isoforms and the molecular pathways specifically involved in inducing cognitive enhancement.
Dissertation
Modifying the comet assay for measuring global DNA methylation in a variety of tissue cells
TL;DR: The methylation sensitive comet assay is indeed able to show clear variations in DNA methylation after treatment of cultured cells and was successfully modified to determine changes in the level of global and regionalDNA methylation in single cells.
Book ChapterDOI
Behavioral genetics and animal domestication
TL;DR: In this paper , the authors define domestication as a genetic process whereby animals change phenotypically and genetically as a response to living under human supervision, through a combination of relaxed natural selection, increased human selection, and correlated responses.
Age-related changes in Arc transcription and DNA methylation within the hippocampus
TL;DR: Data is presented suggesting that aberrant changes in methylation of the Arc gene may be responsible for age-related decreases in Arc transcription within CA1 and the DG, and these subregion-specific epigenetic and transcriptional changes may result in less efficient memory storage and retrieval during aging.
References
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Journal ArticleDOI
A synaptic model of memory: long-term potentiation in the hippocampus
TL;DR: The best understood form of long-term potentiation is induced by the activation of the N-methyl-d-aspartate receptor complex, which allows electrical events at the postsynaptic membrane to be transduced into chemical signals which, in turn, are thought to activate both pre- and post Synaptic mechanisms to generate a persistent increase in synaptic strength.
Journal ArticleDOI
Chromatin Modifications and Their Function
TL;DR: The surface of nucleosomes is studded with a multiplicity of modifications that can dictate the higher-order chromatin structure in which DNA is packaged and can orchestrate the ordered recruitment of enzyme complexes to manipulate DNA.
Journal ArticleDOI
Translating the Histone Code
Thomas Jenuwein,C. David Allis +1 more
TL;DR: It is proposed that this epigenetic marking system represents a fundamental regulatory mechanism that has an impact on most, if not all, chromatin-templated processes, with far-reaching consequences for cell fate decisions and both normal and pathological development.
Journal ArticleDOI
DNA methylation patterns and epigenetic memory
TL;DR: The heritability of methylation states and the secondary nature of the decision to invite or exclude methylation support the idea that DNA methylation is adapted for a specific cellular memory function in development.
Journal ArticleDOI
Epigenetic regulation of gene expression: how the genome integrates intrinsic and environmental signals
Rudolf Jaenisch,Adrian Bird +1 more
TL;DR: Advances in the understanding of the mechanism and role of DNA methylation in biological processes are reviewed, showing that epigenetic mechanisms seem to allow an organism to respond to the environment through changes in gene expression.