Journal ArticleDOI
Epigenetic codes in cognition and behaviour.
TLDR
Recent findings on the role and mechanisms of epigenetic codes in the brain are described, and their implication in synaptic plasticity, cognitive functions and psychiatric disorders are discussed.About:
This article is published in Behavioural Brain Research.The article was published on 2008-09-01. It has received 260 citations till now. The article focuses on the topics: Epigenetic code & Epigenetics.read more
Citations
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Socioeconomic status and the developing brain
TL;DR: These studies indicate that SES is an important predictor of neurocognitive performance, particularly of language and executive function, and that S ES differences are found in neural processing even when performance levels are equal.
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Lasting epigenetic influence of early-life adversity on the BDNF gene.
TL;DR: An epigenetic molecular mechanism potentially underlying lifelong and transgenerational perpetuation of changes in gene expression and behavior incited by early abuse and neglect is highlighted.
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Transcription Factors in Long-Term Memory and Synaptic Plasticity
TL;DR: The results of this work suggest that patterns of transcription regulation represent the molecular signatures of long-term synaptic changes and memory formation.
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Histone acetylation: molecular mnemonics on the chromatin
TL;DR: As histone acetylation and cognitive functions can be pharmacologically restored by histone deacetylase inhibitors, this epigenetic modification might constitute a molecular memory aid on the chromatin and, by extension, a new template for therapeutic interventions against cognitive frailty.
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Finding the engram.
TL;DR: This Review develops four defining criteria that enable us to critically assess the recent progress that has been made towards finding the engram, and proposes that findings from 'capture' studies represent considerable progress in allowing us to observe, erase and express the engrams.
References
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Journal ArticleDOI
Germline epimutation of MLH1 in individuals with multiple cancers
TL;DR: Two individuals with soma-wide, allele-specific and mosaic hypermethylation of the DNA mismatch repair gene MLH1 are reported, with one having had multiple primary tumors that show mismatch repair deficiency and both meeting clinical criteria for hereditary nonpolyposis colorectal cancer.
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Effects of chronic exposure to cocaine are regulated by the neuronal protein Cdk5
James A. Bibb,Jingshan Chen,Jane R. Taylor,Per Svenningsson,Akinori Nishi,Akinori Nishi,Gretchen L. Snyder,Zhen Yan,Zhen Yan,Zachary K. Sagawa,Charles C. Ouimet,Angus C. Nairn,Eric J. Nestler,Eric J. Nestler,Paul Greengard +14 more
TL;DR: The results suggest that changes in Cdk5 levels mediated by ΔFosB, and resulting alterations in signalling involving D1 dopamine receptors, contribute to adaptive changes in the brain related to cocaine addiction.
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Antidepressant-like effects of the histone deacetylase inhibitor, sodium butyrate, in the mouse
TL;DR: The histone deacetylase inhibitor SB exerts antidepressant-like effects in the mouse and the therapeutic benefits and molecular actions of histone modifying drugs, including co-treatment with SSRIs and other newer generation antidepressant medications, warrant further exploration in experimental models.
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A CBP Binding Transcriptional Repressor Produced by the PS1/ϵ-Cleavage of N-Cadherin Is Inhibited by PS1 FAD Mutations
Philippe Marambaud,Paul H. Wen,Anindita Dutt,Junichi Shioi,Akihiko Takashima,Robert Siman,Nikolaos K. Robakis +6 more
TL;DR: It is shown that a PS1-dependent gamma-secretase protease activity promotes an epsilon-like cleavage of N-cadherin to produce its intracellular domain peptide, N-Cad/CTF2, which functions as a potent repressor of CBP/CREB-mediated transcription.
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Neuroprotective Effects of Phenylbutyrate in the N171-82Q Transgenic Mouse Model of Huntington's Disease
Gabriella Gárdián,Susan E. Browne,Dong-Kug Choi,Péter Klivényi,Jason Gregorio,James K. Kubilus,James K. Kubilus,Hoon Ryu,Hoon Ryu,Brett Langley,Rajiv R. Ratan,Rajiv R. Ratan,Robert J. Ferrante,Robert J. Ferrante,M. Flint Beal +14 more
TL;DR: Results show that administration of phenylbutyrate, at doses that are well tolerated in man, exerts significant neuroprotective effects in a transgenic mouse model of HD, and therefore represents a very promising therapeutic approach for HD.